BME100 s2014:W Group8 L2

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Lab Write-Up 1 | Lab Write-Up 2 | Lab Write-Up 3
Lab Write-Up 4 | Lab Write-Up 5 | Lab Write-Up 6
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OUR TEAM

Gabriela Coote
Brianna Snyder
Yesenia Meadows
Ethan J. Wheeler
Chloe Houlihan


LAB 2 WRITE-UP

Descriptive Statistics

Rat Study
Mean: 10.814 pg/mL
Standard Deviation: 5.163 pg/mL
Standard Error: 1.633 pg/mL

Human Study
Mean: 183.082 pg/mL
Standard Deviation: 297.137 pg/mL
Standard Error:46.981 pg/mL




Results

Rat Study
p-value: 0.867403497



Human Study
p-value: 4.91059E-05
Bonferroni Correction:

Post-hoc Tests	t-test value	Corrected p-value to achieve significance	Significant?

0mg vs. 5mg 	8.59631E-07	0.00833                                   	yes
0mg vs. 10mg	9.94377E-06	0.00833                                  	yes
0mg vs. 15mg	1.39436E-08	0.00833	                                        yes 
5mg vs. 10mg	3.01859E-05	0.00833	                                        yes
5mg vs. 15mg	1.57101E-08	0.00833	                                        yes
10mg vs. 15mg	6.4824E-08	0.00833	                                        yes 





Analysis

Rat Study
A T-Test was performed because there are only two different dosages: 0mg and 10mg. The p-value for this study is not significant because it is greater than 0.05.

Human Study
ANOVA was performed because there were four different dosages: 0mg, 5mg, 10mg, and 15mg. Since the p-value of the ANOVA was less than 0.05, it was significant. Therefore, a Bonferroni Correction had to be performed to see if the results were significant.




Summary/Discussion

In the rat study, the difference in inflammotin levels caused by the LPS was not significant because the p-value was greater than 0.05. In contrast, the difference in inflammotin levels caused by the LPS in the human study was significant because the p-value was less than 0.05. The significance between each change in dose was also significant because the p-value was less than 0.00833. 0.00833 was used because it is 0.05/6, 6 being the number of T-Tests that were run. This means that the LPS works to increase inflammotin levels in humans but does not necessarily work to increase inflammotin levels in rats. This could be a result of how few rats were tested compared to humans. At each dosage, ten humans were tested but only five rats were tested. Biological differences could also be a factor.