BME100 s2014:W Group8 L2

BME 100 Fall 2013	Home People Lab Write-Up 1 | Lab Write-Up 2 | Lab Write-Up 3 Lab Write-Up 4 | Lab Write-Up 5 | Lab Write-Up 6 Course Logistics For Instructors Photos Wiki Editing Help
OUR TEAM Gabriela Coote Brianna Snyder Yesenia Meadows Ethan J. Wheeler Chloe Houlihan LAB 2 WRITE-UP Descriptive Statistics Rat Study Mean: 10.814 pg/mL Standard Deviation: 5.163 pg/mL Standard Error: 1.633 pg/mL Human Study Mean: 183.082 pg/mL Standard Deviation: 297.137 pg/mL Standard Error:46.981 pg/mL Results Rat Study p-value: 0.867403497 ‎Human Study p-value: 4.91059E-05 Bonferroni Correction: Post-hoc Tests t-test value Corrected p-value to achieve significance Significant? 0mg vs. 5mg 8.59631E-07 0.00833 yes 0mg vs. 10mg 9.94377E-06 0.00833 yes 0mg vs. 15mg 1.39436E-08 0.00833 yes 5mg vs. 10mg 3.01859E-05 0.00833 yes 5mg vs. 15mg 1.57101E-08 0.00833 yes 10mg vs. 15mg 6.4824E-08 0.00833 yes Analysis Rat Study A T-Test was performed because there are only two different dosages: 0mg and 10mg. The p-value for this study is not significant because it is greater than 0.05. Human Study ANOVA was performed because there were four different dosages: 0mg, 5mg, 10mg, and 15mg. Since the p-value of the ANOVA was less than 0.05, it was significant. Therefore, a Bonferroni Correction had to be performed to see if the results were significant. Summary/Discussion In the rat study, the difference in inflammotin levels caused by the LPS was not significant because the p-value was greater than 0.05. In contrast, the difference in inflammotin levels caused by the LPS in the human study was significant because the p-value was less than 0.05. The significance between each change in dose was also significant because the p-value was less than 0.00833. 0.00833 was used because it is 0.05/6, 6 being the number of T-Tests that were run. This means that the LPS works to increase inflammotin levels in humans but does not necessarily work to increase inflammotin levels in rats. This could be a result of how few rats were tested compared to humans. At each dosage, ten humans were tested but only five rats were tested. Biological differences could also be a factor.