BME100 s2014:W Group8 L2

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Owwnotebook icon.png BME 100 Fall 2013 Home
Lab Write-Up 1 | Lab Write-Up 2 | Lab Write-Up 3
Lab Write-Up 4 | Lab Write-Up 5 | Lab Write-Up 6
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Gabriela Coote
Brianna Snyder
Yesenia Meadows
Ethan J. Wheeler
Chloe Houlihan


Descriptive Statistics

Rat Study
Mean: 10.814 pg/mL
Standard Deviation: 5.163 pg/mL
Standard Error: 1.633 pg/mL

Human Study
Mean: 183.082 pg/mL
Standard Deviation: 297.137 pg/mL
Standard Error:46.981 pg/mL


Rat Study
p-value: 0.867403497

Human Study
p-value: 4.91059E-05
Bonferroni Correction:

Post-hoc Tests	t-test value	Corrected p-value to achieve significance	Significant?

0mg vs. 5mg 	8.59631E-07	0.00833                                   	yes
0mg vs. 10mg	9.94377E-06	0.00833                                  	yes
0mg vs. 15mg	1.39436E-08	0.00833	                                        yes 
5mg vs. 10mg	3.01859E-05	0.00833	                                        yes
5mg vs. 15mg	1.57101E-08	0.00833	                                        yes
10mg vs. 15mg	6.4824E-08	0.00833	                                        yes 


Rat Study
A T-Test was performed because there are only two different dosages: 0mg and 10mg. The p-value for this study is not significant because it is greater than 0.05.

Human Study
ANOVA was performed because there were four different dosages: 0mg, 5mg, 10mg, and 15mg. Since the p-value of the ANOVA was less than 0.05, it was significant. Therefore, a Bonferroni Correction had to be performed to see if the results were significant.


In the rat study, the difference in inflammotin levels caused by the LPS was not significant because the p-value was greater than 0.05. In contrast, the difference in inflammotin levels caused by the LPS in the human study was significant because the p-value was less than 0.05. The significance between each change in dose was also significant because the p-value was less than 0.00833. 0.00833 was used because it is 0.05/6, 6 being the number of T-Tests that were run. This means that the LPS works to increase inflammotin levels in humans but does not necessarily work to increase inflammotin levels in rats. This could be a result of how few rats were tested compared to humans. At each dosage, ten humans were tested but only five rats were tested. Biological differences could also be a factor.