OpenSourceMalaria:GSK Amino-thienopyrimidine Series: Difference between revisions
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[https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL581088 | chEMBL] | [https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL581088 | chEMBL] | ||
[https://www.chemspider.com/Chemical-Structure.24575349.html?rid=a5689148-4b7f-4b14-b9e6-7d03c39148df | ChemSpider] | [https://www.chemspider.com/Chemical-Structure.24575349.html?rid=a5689148-4b7f-4b14-b9e6-7d03c39148df | ChemSpider] | ||
SMILES: Nc1ncnc2cc(sc12)c3cccc(c3)S(=O)(=O)N | |||
InChI=1S/C12H10N4O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18) | |||
The proposed synthesis for this compound is below: | The proposed synthesis for this compound is below: |
Revision as of 05:52, 7 February 2012
GSK Thienopyrimidine Series
The series lead has the following generic structure:
SMILES: Nc1ncnc2cc(sc12)c3cccc(c3)S(=O)(=O)N
InChI=1S/C12H10N4O2S2/c13-12-11-9(15-6-16-12)5-10(19-11)7-2-1-3-8(4-7)20(14,17)18/h1-6H,(H2,13,15,16)(H2,14,17,18)
The proposed synthesis for this compound is below:
References
Castenado, G.; Dotson, J.; Goldsmith, R.; Gunzo, J.; Heffron, T.; Mathieu, S.; Oliveo, A.; Staben, S.; Sutherlin, D.P.; Tsui, V.; Wang, S.; Zhu, B.; Bayliss, T.; Chuckowree, I.; Folkes, A.; Wan, N.C. (Genentech, Inc., USA; Piramed Limited). Thienopyrimidine and furopyrimidine derivatives as phosphoinositide 3-kinase inhibitor and their preparation, pharmaceutical compositions and use in the treatment of cancer. World Intellectual Property Organisation 2008073785 A2, 2008; SciFinder Scholar AN 2008:735944 (accessed 2/2/2012).
Son, J.B.; Jung, S. H.; Choi, W.I.; Jung, Y.H.; Choi, J.Y.; Song, J.Y.; Lee, K.H.; Lee, J.C.; Kim, E.Y.; Ahn, Y.G.; Kim, M.S.; Choi, HG.; Sim, T.B.; Ham, Y.J.; Park, D.; Kim, H.; Kim, D. (Hanmi Holdings Co., Ltd., S. Korea; Korea Institute of Science and Technology; Catholic University Industry Academic Cooperation Foundation). Preparation of thienopyrimidine derivatives for use as protein kinase inhibitors. World Intellectual Property Organisation 2011093684 A2, 2011; SciFinder Scholar AN 2011:971406 (accessed 3/2/2012).