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Abstract

The immune system is not fail-safe and sometimes requires a booster during an infection. Here we design a versatile jellyfish-like device/nano-robot that is able to enhance the immune system. We have chosen the hemagglutinin type 5 protein (H5) of influenza virus as our target because current treatment faces problems of drug resistance and lengthy vaccine production. The device, initially a ball-shaped dimer, contains two types of tentacles, one being H5 aptamer, and the other being either poly-cytosine (poly-C) or poly-guanine (poly-G) sequences. Upon binding H5, the dimer dissociates, releasing the packaged immuno-stimulatory molecule and exposing poly-C and poly-G. Binding between poly-C and poly-G allows aggregation of the virus-bound monomer. The device/nano-robot is versatile since targets could be modified by changing the attached aptamers. It could potentially provide better treatment for diseases such as HIV/AIDS and malaria, as well as enhance experimental techniques such as bioassays and protein purification.

Idea

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Design" style="color:white"/>Design

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Origami" style="color:white"/>Origami

Project

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Method"style="color:white;"/>Method

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Result"style="color:white;"/>Result

Experiment

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Member"style="color:white;">Member

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Review"style="color:white;"/>Review

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Future"style="color:white;"/>Future

Discussion

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Protocol"style="color:white;"/>Protocol

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Material"style="color:white;"/>Material

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Equipment"style="color:white;"/>Equipment

Supplement

<a href="http://openwetware.org/wiki/Biomod/2014/NTU/Acknowledge"style="color:white;"/>Acknowledge

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Biomod/2014/NTU

Contents

NANOJELLYFISH