Haynes Lab: Difference between revisions
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[[Image:Hayneslab3.gif|link=Haynes_Lab]] [[Image:Asu_logo_3.gif|right|link=http://engineering.asu.edu/]]<br> | |||
[[Image: | [[Haynes_Lab | <font face="trebuchet ms" style="color:#000000"> '''Home''' </font>]] | ||
[[Haynes_Lab | <font face="trebuchet ms" style="color:#000000"> '''Home''' </font>]] | [[Haynes:Publications | <font face="trebuchet ms" style="color:#000000"> '''Publications''' </font>]] | ||
[[Haynes: | [[Haynes:Lab Members | <font face="trebuchet ms" style="color:#000000"> '''People''' </font>]] | ||
[[Haynes: | [[Haynes:Contact | <font face="trebuchet ms" style="color:#000000"> '''Contact''' </font>]] | ||
[[Haynes: | [[Haynes:Protocols | <font face="trebuchet ms" style="color:#000000"> '''Protocols''' </font>]] | ||
[[Haynes: | [[Haynes:TechResources | <font face="trebuchet ms" style="color:#000000"> '''Lab Resources''' </font>]] | ||
[[Haynes: | [[Haynes:Internal | <font face="trebuchet ms" style="color:#000000"> '''Personnel''' </font>]] | ||
[[Haynes: | [[Haynes:Calendar | <font face="trebuchet ms" style="color:#000000"> '''Calendar''' </font>]] | ||
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Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans. | |||
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CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS<br> | |||
'''Synthetic chromatin for cell differentiation''' | |||
* David Barclay (FURI & SynBERC, BS) - pancreas, Jan Simper (FURI, BS) - cardiac | |||
* Description: Testing the "PcTF" synthetic chromatin protein/ transcription activator described in [http://www.ncbi.nlm.nih.gov/pubmed/21669865 Haynes & Silver 2011] to determine its ability to alter the phenotypes of healthy cells, such as pancreas beta cells and iPSC's. | |||
'''Editing synthetic genes using CRISPR''' | |||
* René Davis (Biological Design, PhD) | |||
* Description: Characterizing chromatin/CRISPR interactions. Re-engineering synthetic gene circuits in human cells using CRISPR. | |||
'''Engineering synthetic chromatin transcription factors''' | |||
* Cameron Gardner (FURI, BS) | |||
* Description: Building and testing re-engineered versions of the "PcTF" synthetic chromatin protein/ transcription activator described in [http://www.ncbi.nlm.nih.gov/pubmed/21669865 Haynes & Silver 2011]. | |||
'''Microbial communication with synthetic quorum sensing''' | |||
* René Davis (Biological Design, PhD), Ryan Muller (SOLUR, BS) | |||
* Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria. | |||
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'''Lab Notebooks - Active''' {{hide| | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/SynBERC_Scholars_2013 Alfonso & Zazu] | |||
* [http://openwetware.org/wiki/User:Behzad_Damadzadeh/Notebook/PcTF_Subcloning_in_E-coli Behzad] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Engineering_PC-TFs Cameron] | |||
* [http://openwetware.org/wiki/User:David_Barclay/Notebook David Barclay] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Heathers_Lab_Notebook Heather] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Jan Jan] | |||
* [http://openwetware.org/wiki/User:Karmella_Haynes/Notebook Karmella] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Lab_Traning_-_Pradyumna_Kadambi#Pradyumna_Kadambi.2FUndergraduate_Lab_Traning Prad] | |||
* [http://openwetware.org/wiki/User:Rene_M_Davis/Notebooks René - Quorum Sensing] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/CRISPR_Editing René - CRISPR Editing] | |||
* [http://openwetware.org/wiki/User:Brendan_F._Fries/Notebook/Brendan_Fries Brendan] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook:Shared/Cloning_Bootcamp Cloning Bootcamp] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Short_Projects Short Projects] | |||
}} | |||
'''Lab Notebooks - Archived''' {{hide| | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Chimera_Biosensor_%28C.R.SYS%29 Abhi] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Inteins Amanda] | |||
* [http://openwetware.org/wiki/Carly's_Lab_Notebook Carly] | |||
* [http://openwetware.org/wiki/User:David_Dreher/Notebook/Chromatin_controlled_cell_pattern David Dreher] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Heathers_Lab_Notebook Heather] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/James_Alling James] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Lab_Traning_-_Pradyumna_Kadambi#Pradyumna_Kadambi.2FUndergraduate_Lab_Traning Prad] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/Investigating_Photo-Switchable_Synthetic_Nucleosomes Vi] | |||
* [http://openwetware.org/wiki/User:Wesley_J._Houston/Notebook/MAP Wesley] | |||
* [http://openwetware.org/wiki/Haynes_Lab:Notebook/ASU_iGEM ASU iGEM 2012] | |||
}} | |||
'''[https://benchling.com/hayneslab Benchling]'''<br> | |||
'''[https://trello.com/hayneslab Trello Boards]''' |
Revision as of 16:49, 13 November 2014
Our group uses synthetic, systems, and quantitative biology to engineer useful gene and protein-based biological devices and to deepen our understanding of molecular cell biology. We operate biological devices primarily in human/ mammalian cells. Accelerating the pace of therapeutic technologies (such as tissue regeneration and customizable protein-based drugs) via modular design is the grand challenge that shapes our research plans.
CURRENT SYNTHETIC BIOMEDICAL ENGINEERING PROJECTS
Synthetic chromatin for cell differentiation
- David Barclay (FURI & SynBERC, BS) - pancreas, Jan Simper (FURI, BS) - cardiac
- Description: Testing the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011 to determine its ability to alter the phenotypes of healthy cells, such as pancreas beta cells and iPSC's.
Editing synthetic genes using CRISPR
- René Davis (Biological Design, PhD)
- Description: Characterizing chromatin/CRISPR interactions. Re-engineering synthetic gene circuits in human cells using CRISPR.
Engineering synthetic chromatin transcription factors
- Cameron Gardner (FURI, BS)
- Description: Building and testing re-engineered versions of the "PcTF" synthetic chromatin protein/ transcription activator described in Haynes & Silver 2011.
Microbial communication with synthetic quorum sensing
- René Davis (Biological Design, PhD), Ryan Muller (SOLUR, BS)
- Description: Characterizing cross-talk between decoupled cell-cell communication systems from bacteria.
Lab Notebooks - Active
Lab Notebooks - Archived