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Qianben Wang Laboratory

Laboratory of Cancer Epigenomics

Department of Cancer Biology and Genetics, The Ohio State University

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  • Tang X, Liu H, Srivastava A, Pecot T, Chen Z, Wang Q, Huang K, Saenz-Robles MT, Cantalupo P, Pipas J, and Leone G (2016) "Transcriptome regulation and chromatin occupancy by E2F3 and MYC in mice" Sci Data 3:160008 [[1]].

  • Sunkel B^, Wu D^, Chen Z, Wang CM, X Liu, Ye Z, Horning AM, Liu J, Mahalingam D, Lopez-Nicora H, Lin CL, Goodfellow PJ, Clinton SK, Jin VX, Chen CL, Huang TH, and Wang Q (2016) "Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence" Nucleic Acids Res in press January 6, 2016 (^ first authors) [[2]]

  • Chen Z*, Lan X, Wu D, Sunkel B, Ye Z, Huang J, Liu Z, Clinton SK, Jin VX and Wang Q* (2015) "Ligand-dependent genomic function of glucocorticoid receptor in triple-negative breast cancer" Nat Commun 6:8323 (* Corresponding authors) [[3]]

  • Chen K^, Chen Z^, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q* and Li W* (2015) "Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes" Nat Genet 47(10):1149-1157 (^first authors, *Corresponding authors) [[4]].

  • Liu H, Tang X, Srivastava A, Pécot T, Daniel P, Hemmelgarn B, Reyes S, Fackler N, Bajwa A, Kladney R, Koivisto C, Chen Z, Wang Q, Huang K, Machiraju R, Sáenz-Robles MT, Cantalupo P, Pipas JM, Leone G (2015) "Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles" Nat Cell Biol 17(8):1036-1048 [[5]]

  • He H, Li W, Liyanarachchi S, Srinivas M, Wang Y, Akagi K, Wang Y, Wu D, Wang Q, Jin V, Symer DE, Shen R, Phay J, Nagy R, de la Chapelle A (2015) "Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer" Proc Natl Acad Sci U S A 112(19):6128-6133 [[6]]

  • Chen Z^, Lan X^, Thomas-Ahner, JM, Wu D,Liu X, Ye Z, Wang L, Sunkel B, Grenade C, Chen J, Zynger DL, Yan PS, Huang J, Nephew KP, Huang THM, Lin S, Clinton SK, Li W, Jin VX, Wang Q (2015) "Agonist and antagonist switch DNA motifs recognized by human androgen receptor in prostate cancer" EMBO J 34(4):502-16 (^ first author) [[7]]

  • Wu D^, Sunkel B^, Chen Z, Liu X, Ye Z, Li Q, Grenade C, Ke J, Chen H, Nephew KP, Huang THM, Liu Z, Jin VX, Wang Q (2014) “Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer” Nucleic Acids Res 42(6):3607-3622 (^ first author) Full Article (Breakthrough Article) [[8]]

  • Ye Z^, Chen Z^, Lan X, Hara S, Sunkel B, Huang THM, Elnitski L, Wang Q*, Jin VX* (2014) “Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors” Nucleic Acids Res 42(5):2856-2869 (^ first author, * corresponding authors) Full Article

  • Chen H, Ma J, Sunkel B, Luo A, Ding F, Li Y, He H, Zhang S, Xu C, Jin Q, Wang Q, Liu Z (2013) “S100A14 is a novel modulator of terminal differentiation of esophageal squamous cell carcinoma” Mol Cancer Res 11(12):1542-1553 [[9]]

  • He H, Li W, Wu D, Nagy R, Liyanarachchi S, Akagi K, Jendrzejewski J, Jiao H, Hoag K, Wen B, Srinivas M, Waidyaratne G, Wang R, Wojcicka A, Lattimer IR, Stachlewska E, Czetwertynska M, Dlugosinska J, Gierlikowski W, Ploski R, Krawczyk M, Jazdzewski K, Kere J, Symer DE, Jin V, Wang Q, de la Chapelle A (2013) “Ultra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance” PLoS One 8(5):e61920. [[10]]

  • Cai C, Wang H, He HH, Chen S, He L, Ma F, Mucci L, Wang Q, Fiore C, Sowalsky AG, Loda M, Liu XS, Brown M, Balk SP, Yuan X (2013) “ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer” J Clin Invest 123(3):1109-1122. [[11]]

  • Sunkel B, Wang Q (2013) "Chromatin Looping and Long Distance Regulation by Androgen Receptor" Androgen-Responsive Genes in Prostate Cancer Wang, Z., Ed. Springer: New York, 2013. [[12]]

  • Cui J, Germer K, Wu T, Wang J, Luo J, Wang SC, Wang Q, Zhang X (2012) “Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells” Cancer Res 72(21):5625-5634. [[13]]

  • Sunkel B, Wang Q (2012) “Mapping mutations in prostate cancer exomes” Asian J Androl 14(6):801-802. [[14]]

  • Lan X, Witt H, Katsumura K, Ye Z, Wang Q, Bresnick EH, Farnham PJ, Jin VX (2012) “Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages” Nucleic Acids Res 40(16):7690-7704. [[15]]

  • Taslim C, Chen Z, Huang K, Huang TH, Wang Q*, Lin S* (2012) "Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF" Nucleic Acids Res 40(11):4754-4764 (*corresponding author). Full Article and Supplemental[[16]]

  • Zhao JC, Yu J, Runkle C, Wu L, Hu M, Wu D, Liu JS, Wang Q, Qin ZS, Yu J (2012) "Cooperation between Polycomb and androgen receptor during oncogenic transformation" Genome Res 22(2):322-31. Full Article and Supplemental [[17]]

  • Wu D, Zhang C, Shen Y, Nephew KP, Wang Q (2011) "Androgen receptor-driven chromatin looping in prostate cancer" Trends Endocrinol Metab 22(12):474-80. Full Article and Supplemental [[18]]

  • Zhang C^, Wang L^, Wu D^, Chen H, Chen Z, Thomas-Ahner JM, Zynger DL, Eeckhoute J, Yu J, Luo J, Brown M, Clinton SK, Nephew KP, Huang TH, Li W*, Wang Q* (2011) "Definition of a FoxA1 Cistrome That Is Crucial for G1 to S-Phase Cell-Cycle Transit in Castration-Resistant Prostate Cancer" Cancer Res 71(21):6738-6748. (^ first author, * corresponding author) Full Article and Supplemental [[19]]

  • Wang H, Zhang C, Rorick A, Wu D, Chiu M, Thomas-Ahner J, Chen Z, Chen H, Clinton SK, Chan KK, Wang Q (2011) " CCI-779 Inhibits Cell-Cycle G2/M Progression and Invasion of Castration-Resistant Prostate Cancer via Attenuation of UBE2C Transcription and mRNA Stability" Cancer Res 71(14):4866-76. Full Article and Supplemental [[20]]

  • Chen Z, Zhang C, Wu D, Chen H, Rorick A, Zhang X, Wang Q (2011) "Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth" EMBO J 30(12):2405-19. Full Article and Supplemental [[21]]

  • Chen CH, Huang PH, Chiu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q and Chen CS (2011) "Energy restriction-mimetic agents induce apoptosis in prostate cancer cells, in part, through epigenetic activation of KLF6 tumor suppressor gene expression" J Biol Chem 286(12):9968-76. Full Article [[22]]

  • Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR and McDonnell DP (2011) "CaM Kinase Kinase {beta}-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells" Cancer Res 71(2):528-37. Full Article Supplementary data and Supplementary methods [[23]]

  • Chen Z,^,Wang L^, Wang Q*, Li W* (2010) "Histone modifications and chromatin organization in prostate cancer" Epigenomics 2(4):551-60 (^ first author, * corresponding author). Full Article [[24]]

  • Hsu PY, Hsu HK, Singer GA, Yan PS, Rodriguez BA, Liu JC, Weng YI, Deatherage DE, Chen Z, Pereira JS, Lopez R, Russo J, Wang Q, Lamartiniere CA, Nephew KP and Huang TH (2010) "Estrogen-mediated epigenetic repression of large chromosomal regions through DNA looping" Genome Res 20(6):733-44. Full Article [[25]]

  • He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M and Liu XS (2010) "Nucleosome dynamics define transcriptional enhancers" Nat Genet 42(4):343-7.Full Article [[26]]

  • Wang Q*^, Li W^, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Ja¨ nne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS,* Brown M,* (2009) "Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer" Cell 138:245-56 (^ first author, * corresponding author). (Featured Article). Full Article and Supplemental [[27]]
    Highlighted by: Faculty of 1000 [[28]] and Nature Reviews Cancer [[29]]

  • Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, McDonnell DP (2009) "Induction of Kruppel-like factor 5 expression by androgens results in increased CXCR4-dependent migration of prostate cancer cells in vitro" Mol Endocrinol. 23(9):1385-96. Full Article [[30]]

  • Sun T, Wang Q, Balk SP, Brown M, Lee GS and Kantoff PW (2009) "Roles of microRNA-221 and -222 in castration resistant prostate cancer" Cancer Res 69:3356-63. [[31]]

  • Wang Q and Brown M (2009) "Mapping the androgen receptor cistrome" In Tindall DJ and Mohler JL, eds. Androgen Action in Prostate Cancer, New York, NY: Springer Science and Business Media, pp.663-80. [[32]]

  • Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ and Logan SK (2009) "Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells" Cancer Res.69(7):3140-7. [[33]]

  • Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Carroll JS, Liu XS, and Brown M (2008) "FoxA1 translates epigenetic signatures into lineage-specific transcription" Cell 132:958-70. [[34]]

  • Bao BY, Chuang BF, Wang Q, Kantoff PW, Brown M, Sartor O, and Lee GS (2008) "Regulation of UGT2B15/17 by androgen signaling in prostate cancer cells" Prostate 68:839-48. [[35]]

  • Agoulnik IU, Bingman WE 3rd, Nakka M, Li W, Wang Q, Liu XS, Brown M, Weigel NL (2008) "Target gene-specific regulation of androgen receptor activity by p42/p44 mitogen-activated protein kinase" Mol Endocrinol 22: 2420-32. [[36]]

  • Wang Q, Li W, Liu XS, Carroll JS, Jänne OA, Keeton EK, Chinnaiyan AM, Pienta KJ and Brown M (2007) "A hierarchical network of transcription factors governs androgen receptor dependent prostate cancer growth" Mol Cell 27:380-92 (Featured Article). [[37]]

  • Wang QF, Prabhakar S, Wang Q, Moses AM, Chanan S, Brown M, Eisen MB, Cheng JF, Rubin EM, and Boffelli D (2006) "Primate-specific evolution of an LDLR enhancer" Genome Biol 7: R68. [[38]]

  • Carroll JS, Meyer CA, Song J, Li W, Brodsky AS, Geistlinger TR, Eeckhoute J, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS and Brown M (2006) "Genome wide analysis of estrogen receptor binding sites" Nat Genet 38:1289-97. [[39]]

  • Wang Q, Carroll JS and Brown M (2005) "Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking" Mol Cell 19:631-42. [[40]]

  • Wang Q, Udayakumar TS, Vasaitis TS, Brodie AH and Fondell JD(2004) "Mechanistic relationship between androgen receptor polyglutamine tract trucation and androgen-dependent transcriptional hyperactivity in prostate cancer cells" J Biol Chem 279:17319-28. [[41]]

  • Wang H, Wang Q, Srivastava RK, Gong SS, Lao L, Fondell JD, Wang JB (2003) "Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation" Altern Ther Health Med Vol. 9, no. 5:62-66. [[42]]

  • Wang Q, Dipali S, Ren Y and Fondell JD (2002) "A coregulatory role for the TRAP-Mediator complex in androgen receptor-mediated gene expression"' J Biol Chem 277:42852-58. [[43]]

  • Zhang Y, Fondell JD, Wang Q, Xia X, Cheng A, Lu M, Hamburger AW (2002) "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein" Oncogene Vol. 21, no. 36: 5609-5618. [[44]]

  • Wang Q, Fondell JD (2001) "Generation of a mammalian cell line stably expressing a tetracycline-regulated epitope-tagged human androgen receptor: Implications for steroid hormone receptor research" Anal Biochem Vol. 289, no. 2: 217-230.

  • Ren Y, Behre E, Ren Z, Zhang J, Wang Q, Fondell JD (2000) "Specific structural motifs determine TRAP220 interactions with nuclear receptors" Mol Cell Biol Vol. 20, no. 15: 5433-5446.