User:Mbennie/Notebook/Papers and Books/Ron Weiss

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  1. Basu S, Gerchman Y, Collins CH, Arnold FH, and Weiss R. A synthetic multicellular system for programmed pattern formation. Nature. 2005 Apr 28;434(7037):1130-4. DOI:10.1038/nature03461 | PubMed ID:15858574 | HubMed [Pattern-Formation]
  • Built three types of cells that express fluorescent protein when presented with a certain concentration of autoinducer (high, medium, low)
  • Mixture of cells can produce a bullseye when a sender cell is place in the middle
  • Bi-directional communication might be an interesting topic to investigate
  • Use same mechanism, but make cells express different protein such as adhesin (cells only stick together when they detect autoinducer)


  1. Yokobayashi Y, Weiss R, and Arnold FH. Directed evolution of a genetic circuit. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16587-91. DOI:10.1073/pnas.252535999 | PubMed ID:12451174 | HubMed [Directed-evolution]
  • Paper discusses purposely mutating pathways to optimize genetic circuits
  • Fluorescent screening used to discover which mutations made the nonfunctional gate work as intended
  • Good method, but no apparent future work