User:Mbennie/Notebook/Papers and Books/Leucine Zippers

Error fetching PMID 12006103

Error fetching PMID 12805554

• Characterizes interactions between 49 leucine zippers using protein arrays
• Observed that families make similar interactions
• Observed high symmetry
• Figure 2 of this paper shows interactions between 49 leucine zippers, color-coated by strength

Family Alignment for the BRLZ domain

• Click "Family Alignment" to see list of leucine zippers
• Might be useful in locating sequence information for various leucine zippers

Error fetching PMID 16359704

• Leucine zippers have (abcdefg)n repeat - zippers interface with a, d, e, and g residues
• Mostly computational information - predicting results generated by Comprehensive Identification of Human bZIP paper

Error fetching PMID 2683088

• Leucine zippers are Y-shaped, recognize binding sites on DNA
• "Dimer-forming region...hypothesized to consist of two amphipathic alpha helices, about 30 amino acids long, that adhere tightly to one another through a narrow hydrophobic spine punctuated every seven residues by a leucine side chain."
• N-terminus side responsible for DNA binding
• basic region-leucine zipper -> bZIP
• DNA targets are "directly abutted, inverted repeats"

Error fetching PMID 3289117

• Introduces leucine zipper, information about similar methods of gene regulation: helix-turn-helix and zinc fingers
• Compares several leucine zippers and identifies patterns (mainly leucine every seven aa)
• Explains physical properties of leucine that make it ideal candidate for this role