User:Mbennie/Notebook/Papers and Books/Leucine Zippers

1. Ramji DP and Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J. 2002 Aug 1;365(Pt 3):561-75. DOI:10.1042/BJ20020508 |

2. Newman JR and Keating AE. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science. 2003 Jun 27;300(5628):2097-101. DOI:10.1126/science.1084648 |

• Characterizes interactions between 49 leucine zippers using protein arrays
• Observed that families make similar interactions
• Observed high symmetry
• Figure 2 of this paper shows interactions between 49 leucine zippers, color-coated by strength

Family Alignment for the BRLZ domain

• Click "Family Alignment" to see list of leucine zippers
• Might be useful in locating sequence information for various leucine zippers

3. Grigoryan G and Keating AE. Structure-based prediction of bZIP partnering specificity. J Mol Biol. 2006 Feb 3;355(5):1125-42. DOI:10.1016/j.jmb.2005.11.036 |

• Leucine zippers have (abcdefg)n repeat - zippers interface with a, d, e, and g residues
• Mostly computational information - predicting results generated by Comprehensive Identification of Human bZIP paper

4. Vinson CR, Sigler PB, and McKnight SL. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science. 1989 Nov 17;246(4932):911-6. DOI:10.1126/science.2683088 |

• Leucine zippers are Y-shaped, recognize binding sites on DNA
• "Dimer-forming region...hypothesized to consist of two amphipathic alpha helices, about 30 amino acids long, that adhere tightly to one another through a narrow hydrophobic spine punctuated every seven residues by a leucine side chain."
• N-terminus side responsible for DNA binding
• basic region-leucine zipper -> bZIP
• DNA targets are "directly abutted, inverted repeats"

5. Landschulz WH, Johnson PF, and McKnight SL. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science. 1988 Jun 24;240(4860):1759-64. DOI:10.1126/science.3289117 |

• Introduces leucine zipper, information about similar methods of gene regulation: helix-turn-helix and zinc fingers
• Compares several leucine zippers and identifies patterns (mainly leucine every seven aa)
• Explains physical properties of leucine that make it ideal candidate for this role