User:Berthold Drexler
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Welcome to my homepage, hosted by OpenWetWare
I'm a senior physician (cunsultant) at the Department of Anaesthesiology and Intensive Care, University Hospital Tübingen, Eberhard Karls University Tübingen, Germany and member of the Antkowiak Lab.
Berthold Drexler, Experimental Anaesthesiology Section
Department of Anaesthesiology and Intensive Care, University Hospital Tuebingen
Wilhelmstrasse 56, 72072 Tuebingen, Germany
Email me through OpenWetWare
email: berthold DOT drexler AT uni MINUS tuebingen DOT de
Research interests
Mechanisms of Anaesthesia - GABAA Receptor Subtypes - Electrophysiology - Cerebral Cortex - Organotypic Tissue Cultures
Education, Positons and Employment
- Memer of the Ethics Committee
- 2020 Associate Professor (apl.)
- 2014 Assistant Professor (Habilitation/Venia Legendi)
- 2013 ATLS®-Provider ATLS
- 2012 Senior Physician/Consultant Anesthesiology
- 2007-2011 Post Doctoral Fellowship: Experimental Anaesthesiology, Head: Prof. Dr. Bernd Antkowiak
- 11/2010 European Diploma in Intensive Care
- 11/2008 Board Certification Intensive Care Medicine
- 10/2007 European Diploma in Anaesthesiology
- 2007 Board Certification Anaesthesiology
- 1999-2007 Internship and Residency: University Hospital Tübingen, Germany, Department of Anaesthesiology and Intensive Care, Head: Prof. Dr. Klaus Unertl
- 2001 Doctoral Thesis (MD), Albert-Ludwigs-University Freiburg, Cardiology, Supervisor: Prof. Dr. Christian Holubarsch
- 1999 Final Year: Internal Medicine Spital Uster, CH; Heart Surgery Groote Schuur Hospital, SA; Anaesthesiology University Hospital Freiburg
- 1992-98 Albert-Ludwigs-University, Medical School, Freiburg, Germany
Memberships
- Associate Faculty Member of the Faculty of 1000
- European Society of Anaesthesiology
- European Society of Intensive Care Medicine
- German Society for Anesthesiology and Intensive Care Medicine (DGAI)
- Selected mentee of the Mentoring Program for Junior Investigators (DGAI)
- Scientific Working Committee Neuroanesthesia (DGAI)
Selected Publications
- Konrad FM, Mayer AS, Serna-Higuita LM, Hurth H, Tatagiba M, Reutershan J, Rosenberger P, Drexler B: Occurrence and severity of venous air embolism during neurosurgical procedures in semi-sitting versus supine position. World Neurosurgery 2022
- Drexler B, Grenz J, Grasshoff C, Antkowiak B: Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks. International Journal of Molecular Sciences 21:7399, 2020
- Kreuzer M, Butovas S, García PS, Schneider G, Schwarz C, Rudolph U, Antkowiak B, Drexler B: Propofol affects cortico-hippocampal interactions via β3 subunit-containing GABAA receptors. International Journal of Molecular Sciences 21, 5844, 2020
- Kreuzer M, García PS, Brucklacher-Waldert V, Claassen R, Schneider G, Antkowiak B, Drexler B: Diazepam and ethanol differently modulate neuronal activity in organotypic cortical cultures. BMC Neurosci. 2019 Dec 10;20(1):58 BMC
- Neumann E, Rudolph U, Knutson DE, Li G, Cook JM, Hentschke H, Antkowiak B, Drexler B: Zolpidem activation of alpha 1-containing GABAA receptors selectively inhibits high frequency action potential firing of cortical neurons. Frontiers in Pharmacology
- Balk M, Hentschke H, Rudolph U, Antkowiak B, Drexler B: Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices. Scientific Reports 14 June 2017 open access
- Drexler B, Balk M, Antkowiak B: Synergistic modulation of GABA(A) receptor-mediated synaptic inhibition in cortical networks by allopregnanolone and propofol. Anesthesia & Analgesia, 2016
- Drexler B, Zinser S, Hentschke H, Antkowiak B: Diazepam decreases action potential firing of neocortical neurons via two distinct mechanisms Anesthesia & Analgesia 111(6):1394-1399; 2010
- Drexler B, Jurd R, Rudolph U, Antkowiak B: Dual Actions of Enflurane on Postsynaptic Currents Abolished by the γ-Aminobutyric Acid Type A Receptor β3(N265M) Point Mutation Anesthesiology 105: 297-304; 2006
- Drexler B, Roether CL, Jurd R, Rudolph U, Antkowiak B: Opposing Actions of Etomidate on Cortical Theta Oscillations Are Mediated by Different γ-Aminobutyric Acid Type A receptor subtypes Anesthesiology 102: 346-52; 2005
- Jurd R, Arras M, Lambert S, Drexler B, Siegwart R, Crestani F, Zaugg M, Vogt K, Ledermann B, Antkowiak B, Rudolph U: General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor β3 subunit FASEB J 17: 250-252; 2003
Clinical Studies
- POSE trial: Peri-interventional outcome study in the elderly in Europe and Association between benzodiazepine premedication and 30-day mortality rate
- I-PROMOTE trial
- CNS 7056-022
- IMPACT trial
