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[[Image:Pruszak_pluripotent_stem.PNG|270px|thumb|right|'''Pluripotent stem cells:'''<br> Human pluripotent stem cells offer the unprecedented opportunity to study basic principles of development and embryology in a human model system. This lends itself to study self-renewal and cell proliferation on the one hand, and cell fate establishment and stabilization on the other.]] | [[Image:Pruszak_pluripotent_stem.PNG|270px|thumb|right|'''Pluripotent stem cells:'''<br> Human pluripotent stem cells offer the unprecedented opportunity to study basic principles of development and embryology in a human model system. This lends itself to study self-renewal and cell proliferation on the one hand, and cell fate establishment and stabilization on the other. http://dx.doi.org/10.1007/978-1-4614-8066-2_4]] | ||
Human pluripotent stem cells (hPSCs) represent a valuable system to study cellular processes and disease mechanisms in phenotypes of biomedical interest and to derive cells and tissues for regenerative medicine and cell therapy. Neural differentiation of human stem cells represents a promising avenue to derive specific neuronal and glial phenotypes for potential '''cell replacement''' in the therapy of nervous system disease. Among others, therapies are being investigated for degenerative neurological disorders such as Parkinson’s and Huntington’s disease, for glial disorders such as multiple sclerosis or for trauma conditions such as spinal cord injury. PSCs are, in principle, unlimited in their expansion potential and represent an epigenetically “blank slate” that enables directed patterning toward all lineages. Importantly, the differentiation of human neural cell types from human pluripotent stem cells enables the study of '''neural development''' in an understudied model organism to date only remotely accessible to biological discovery: humans.<br> | Human pluripotent stem cells (hPSCs) represent a valuable system to study cellular processes and disease mechanisms in phenotypes of biomedical interest and to derive cells and tissues for regenerative medicine and cell therapy. Neural differentiation of human stem cells represents a promising avenue to derive specific neuronal and glial phenotypes for potential '''cell replacement''' in the therapy of nervous system disease. Among others, therapies are being investigated for degenerative neurological disorders such as Parkinson’s and Huntington’s disease, for glial disorders such as multiple sclerosis or for trauma conditions such as spinal cord injury. PSCs are, in principle, unlimited in their expansion potential and represent an epigenetically “blank slate” that enables directed patterning toward all lineages. Importantly, the differentiation of human neural cell types from human pluripotent stem cells enables the study of '''neural development''' in an understudied model organism to date only remotely accessible to biological discovery: humans.<br> | ||
