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Biomolecular Breadboards: Difference between revisions
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=== DNA origami breadboard === | === DNA origami breadboard === | ||
A | A third breadboard family that we are developing explores the role of spatial localization and single molecule effects. For this, we are using | ||
DNA origami to spatially organize, study, and optimize existing ''in vitro'' transcription circuits such as oscillators. There are two kinds of spatial | DNA origami to spatially organize, study, and optimize existing ''in vitro'' transcription circuits such as oscillators. There are two kinds of spatial | ||
organization that can be effected by DNA origami. The first kind of organization, ''local patterning'' is intrinsic to the DNA origami themselves. For example, a rectangular origami provides a roughly 100~nm x 70~nm surface onto which other molecules can be positioned with a resolution of about 6 nanometers. | organization that can be effected by DNA origami. The first kind of organization, ''local patterning'' is intrinsic to the DNA origami themselves. For example, a rectangular origami provides a roughly 100~nm x 70~nm surface onto which other molecules can be positioned with a resolution of about 6 nanometers. | ||
