Prince:Notebook/PPIX/Candidate Protein Pair

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Properties

• Solved PDB binding structure
  • There are ~10,000 structures with 2 chains on PDB, so plenty of candidates.
• Available in purified state
• Forms a complex in vivo
  • Ideally, this would be manipulatable
• Available in affinity tag form for IP.

Potential Candidates

• Gα/Gβ
  • Gβ/Gγ are only stable when together
  • Gβ/Gγ and their interactions with Phosducin or PhLP are potentially superior candidates
    • There is a directly manipulatible interaction (BMW Lab has an inhibitor of that interaction)
    • Phosducin-Gβ/Gγ structures are known
• JAK/STAT
• GRB2/SOS
• SH2 domain??
• Phos/Jun
• ERK2/MKP1 or MKP3
• R2-AKAP