Prince:Intro to Mass Spectrometry Proteomics

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Here are some introductory resources to the field of Mass Spectrometry Proteomics. Add more as you come across them.

• Mass spectrometry–based proteomics in cell biology - review by Walther & Mann
• Proteome Bioinformatics - book published in 2010, free pdfs available [BYU subscription].
• Bioinformatics for Comparative Proteomics - book published in 2010, free pdfs available [BYU subscription].
• Bioinformatics for Qualitative and Quantitative Proteomics (chapter 15 of Bioinformatics for Omics Data)
• Proteomics by Mass Spectrometry: Approaches, Advances, and Applications (Yates, Ruse, and Nakorchevsky)
• Vitek and Kall overview of computation mass spec proteomics
• Matlab has a series of tutorials that are useful (>>doc help then search for Mass Spectrometry)

Misc

• Comments on standards in proteomics and the concept of fitness-for-purpose - includes discussion of hypothesis driven and exploratory research.

Statistics of Quantitative Proteomics

• Design and analysis issues in quantitative proteomics studies Simple discussion of things like 'power', 'effect size' and multiple hypothesis testing.

Hype

• Yates, Ruse, and Nakorchevsky (see review above)

   "Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale proteomics"

• Interview with Matthias Mann (2007)
• Can Proteomics Retire the Western Blot? (commentary by M. Mann)