Kafatos:Fotis C. Kafatos

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Fotis C. Kafatos

Division of Cell & Molecular Biology
South Kensington Campus, SAF
London, SW7 2AZ


I am one of the PIs in the Kafatos/Christophides Lab at Imperial College, London and Honorary President of the European Research Council as well as Member of its Scientific Council.

Wikipedia Entry
Watch an interview video of me (interviewer: George Dimopoulos, PhD hosted at the JHSPH)
Imperial faculty webpage and Contact Details

Research Interests


1965 PhD, Biology Harvard University, USA.
1962 MA, Biology Harvard University, USA.
1961 AB, Zoology (High Honours) Cornell University, USA.
Primary and secondary education in Crete

Academic Appointments

2007 - present Adjunct Professor of Immunology & Infectious Diseases, Harvard School of Public Health
2005 - present Professor, Chair of Immunogenomics, Imperial College, London, UK.
1993 - 2005 Director General, and group leader at European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
1982 - 1993 Founder and Director, Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, Crete, Greece.
1982 - present Professor of Biology (part-time), University of Crete, Greece, (on leave).
1972 - 1982 Professor of Biology (part-time), University of Athens, Greece.
1978 - 1981 Chair, Cellular and Developmental Biology, Harvard University, USA.
1969 - 1994 Professor of Biology, Harvard University, USA.
1965 - 1969 Assistant Professor of Biology, Harvard University, USA.
1965 Instructor of Biology, Harvard University, USA.


President of the European Research Council and Chairman of its Scientific Council, 2007 - 2011
Fondation Louis Jeantet – 25th Anniversary Special Prize, 2008
Member, European Academy of Sciences and Arts, 2007
Uni-Heidelberg Grosse Universitats Medal, 2005
Medal of Honour, City of Heraklion, Crete, 2004
“Bundesverdienstkreuz 1. Klasse”, awarded by the President of the Federal Republic of Germany, 2004
Medal “Taxiarchis of Phoenix”, awarded by the President of the Hellenic Republic, for contributions to Science, Culture and Society, 2003
Foreign Member of the Royal Society of London, 2003
Member, Pontifical Academy of Sciences, 2003
Foreign Member of the French Academy of Sciences, 2002
Honorary Medal for Distinction in Biology, Academy of Athens, 2000
Honorary Professor, University of Heidelberg, Germany 2000
G.J. Mendel Honorary Gold Medal for Merit in the Biological Sciences, Academy of Sciences of the Czech Republic, 1995
Member, Academia Europaea, 1991
Member, National Academy of Science, USA, 1982
Fellow, American Academy of Arts and Sciences, 1980

Honorary Doctorates

  • Agricultural University of Athens 1992
  • University Thessaloniki 1994
  • Université Louis Pasteur, Strasbourg 2002
  • University of Thrace 2004
  • Cyprus University of Technology 2008

Board Memberships (partial list)

2004 – present

Sanger Institute, Hinxton (UK), Scientific Advisory Board

2004 – 2007

International Risk Governance Council (Geneva), Scientific and Technical Council

2004 – present

Centro Nacional de Investigaciones Oncológicas Carlos III (Spain), Scientific Advisory Board

2003 – present

Bill and Melinda Gates Foundation (Seattle), Scientific Board of “Grand Challenges in Global Health Initiative”

2003 – present

Hellenic Pasteur Institute (Athens), Scientific Committee

2002 – present

Temasek Life Sciences Laboratory (Singapore), International Scientific Advisory Board

2002 – present

Flanders Interuniversity Institute for Biotechnology (VIB), Chair of the Institutional Advisory Board

2002 – 2003

European Intergovernmental Research Organisation Forum (EIROforum), Chair


International Review Panel on Development of Biotechnology in Finland (Chair)

2001 – present

University of Geneva School of Medicine, External Scientific Advisory Board

2000 – present

Institut Pasteur (Paris), External Scientific and Strategic Committee

2000 – present

Sars International Centre for Marine Molecular Biology (Bergen), Scientific Advisory Committee

1998 – 2002

Fondation des Treilles, Scientific Committee

1998 – 2001

Conseil National de la Science, France

1997 – 2002

Fondation Bettencourt Schueller (Paris), Scientific Committee

1995 – present

Max-Planck Institut (Göttingen), Member and Chair of the Fachbeirat

1995 – 2004

Fondation Louis Jeantet de Mèdicine (Geneva), Science Committee

1995 – 2000

Wellcome CRC Institute (Cambridge), International Advisory Board

1994 – present

Institute of Molecular Biology and Biotechnology (Crete), Chair of International Scientific Advisory Board

1994 – 1999

National Science Advisory Board of Greece (Athens)

1991 – 1998

WHO/TDR (Geneva), Steering Committee on Biological Control of Vectors, Molecular Entomology

1991 – 1994

International Centre for Insect Physiology and Ecology (Nairobi), Governing Board/Programme Committee

1988 – 1990

European Molecular Biology Organisation Council

1987 – 1994

Committee for the European Development of Science and Technology – CODEST (European Commission)

1976 – 1993

University of Crete and Foundation of Research and Technology – Hellas Governing Board (overlapping periods)

Publications (partial list)


  1. Lawson D, Arensburger P, Atkinson P, Besansky NJ, Bruggner RV, Butler R, Campbell KS, Christophides GK, Christley S, Dialynas E, Hammond M, Hill CA, Konopinski N, Lobo NF, MacCallum RM, Madey G, Megy K, Meyer J, Redmond S, Severson DW, Stinson EO, Topalis P, Birney E, Gelbart WM, Kafatos FC, Louis C, and Collins FH. VectorBase: a data resource for invertebrate vector genomics. Nucleic Acids Res. 2009 Jan;37(Database issue):D583-7. DOI:10.1093/nar/gkn857 | PubMed ID:19028744 | HubMed [2009ref1]


  1. Pinto SB, Kafatos FC, and Michel K. The parasite invasion marker SRPN6 reduces sporozoite numbers in salivary glands of Anopheles gambiae. Cell Microbiol. 2008 Apr;10(4):891-8. DOI:10.1111/j.1462-5822.2007.01091.x | PubMed ID:18005239 | HubMed [2008ref1]
  2. Mendes AM, Schlegelmilch T, Cohuet A, Awono-Ambene P, De Iorio M, Fontenille D, Morlais I, Christophides GK, Kafatos FC, and Vlachou D. Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. PLoS Pathog. 2008 May 16;4(5):e1000069. DOI:10.1371/journal.ppat.1000069 | PubMed ID:18483558 | HubMed [2008ref2]

All Medline abstracts: PubMed | HubMed


  1. Lawson D, Arensburger P, Atkinson P, Besansky NJ, Bruggner RV, Butler R, Campbell KS, Christophides GK, Christley S, Dialynas E, Emmert D, Hammond M, Hill CA, Kennedy RC, Lobo NF, MacCallum MR, Madey G, Megy K, Redmond S, Russo S, Severson DW, Stinson EO, Topalis P, Zdobnov EM, Birney E, Gelbart WM, Kafatos FC, Louis C, and Collins FH. VectorBase: a home for invertebrate vectors of human pathogens. Nucleic Acids Res. 2007 Jan;35(Database issue):D503-5. DOI:10.1093/nar/gkl960 | PubMed ID:17145709 | HubMed [2007ref1]
  2. Thompson J, Fernandez-Reyes D, Sharling L, Moore SG, Eling WM, Kyes SA, Newbold CI, Kafatos FC, Janse CJ, and Waters AP. Plasmodium cysteine repeat modular proteins 1-4: complex proteins with roles throughout the malaria parasite life cycle. Cell Microbiol. 2007 Jun;9(6):1466-80. DOI:10.1111/j.1462-5822.2006.00885.x | PubMed ID:17253978 | HubMed [2007ref2]
  3. Waterhouse RM, Kriventseva EV, Meister S, Xi Z, Alvarez KS, Bartholomay LC, Barillas-Mury C, Bian G, Blandin S, Christensen BM, Dong Y, Jiang H, Kanost MR, Koutsos AC, Levashina EA, Li J, Ligoxygakis P, Maccallum RM, Mayhew GF, Mendes A, Michel K, Osta MA, Paskewitz S, Shin SW, Vlachou D, Wang L, Wei W, Zheng L, Zou Z, Severson DW, Raikhel AS, Kafatos FC, Dimopoulos G, Zdobnov EM, and Christophides GK. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science. 2007 Jun 22;316(5832):1738-43. DOI:10.1126/science.1139862 | PubMed ID:17588928 | HubMed [2007ref3]
  4. Koutsos AC, Blass C, Meister S, Schmidt S, MacCallum RM, Soares MB, Collins FH, Benes V, Zdobnov E, Kafatos FC, and Christophides GK. Life cycle transcriptome of the malaria mosquito Anopheles gambiae and comparison with the fruitfly Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11304-9. DOI:10.1073/pnas.0703988104 | PubMed ID:17563388 | HubMed [2007ref4]
  5. Pindyurin AV, Moorman C, de Wit E, Belyakin SN, Belyaeva ES, Christophides GK, Kafatos FC, van Steensel B, and Zhimulev IF. SUUR joins separate subsets of PcG, HP1 and B-type lamin targets in Drosophila. J Cell Sci. 2007 Jul 15;120(Pt 14):2344-51. DOI:10.1242/jcs.006007 | PubMed ID:17606990 | HubMed [2007ref5]
  6. Schnitger AK, Kafatos FC, and Osta MA. The melanization reaction is not required for survival of Anopheles gambiae mosquitoes after bacterial infections. J Biol Chem. 2007 Jul 27;282(30):21884-8. DOI:10.1074/jbc.M701635200 | PubMed ID:17537726 | HubMed [2007ref6]
  7. Ecker A, Pinto SB, Baker KW, Kafatos FC, and Sinden RE. Plasmodium berghei: plasmodium perforin-like protein 5 is required for mosquito midgut invasion in Anopheles stephensi. Exp Parasitol. 2007 Aug;116(4):504-8. DOI:10.1016/j.exppara.2007.01.015 | PubMed ID:17367780 | HubMed [2007ref7]

All Medline abstracts: PubMed | HubMed


  1. Volz J, Müller HM, Zdanowicz A, Kafatos FC, and Osta MA. A genetic module regulates the melanization response of Anopheles to Plasmodium. Cell Microbiol. 2006 Sep;8(9):1392-405. DOI:10.1111/j.1462-5822.2006.00718.x | PubMed ID:16922859 | HubMed [2006ref1]
  2. Vlachou D, Schlegelmilch T, Runn E, Mendes A, and Kafatos FC. The developmental migration of Plasmodium in mosquitoes. Curr Opin Genet Dev. 2006 Aug;16(4):384-91. DOI:10.1016/j.gde.2006.06.012 | PubMed ID:16793259 | HubMed [2006ref2]
  3. Lycett GJ, McLaughlin LA, Ranson H, Hemingway J, Kafatos FC, Loukeris TG, and Paine MJ. Anopheles gambiae P450 reductase is highly expressed in oenocytes and in vivo knockdown increases permethrin susceptibility. Insect Mol Biol. 2006 Jun;15(3):321-7. DOI:10.1111/j.1365-2583.2006.00647.x | PubMed ID:16756551 | HubMed [2006ref3]
  4. Moita LF, Vriend G, Mahairaki V, Louis C, and Kafatos FC. Integrins of Anopheles gambiae and a putative role of a new beta integrin, BINT2, in phagocytosis of E. coli. Insect Biochem Mol Biol. 2006 Apr;36(4):282-90. DOI:10.1016/j.ibmb.2006.01.004 | PubMed ID:16551542 | HubMed [2006ref4]
  5. Michel K, Suwanchaichinda C, Morlais I, Lambrechts L, Cohuet A, Awono-Ambene PH, Simard F, Fontenille D, Kanost MR, and Kafatos FC. Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16858-63. DOI:10.1073/pnas.0608033103 | PubMed ID:17065316 | HubMed [2006ref5]
  6. Cohuet A, Osta MA, Morlais I, Awono-Ambene PH, Michel K, Simard F, Christophides GK, Fontenille D, and Kafatos FC. Anopheles and Plasmodium: from laboratory models to natural systems in the field. EMBO Rep. 2006 Dec;7(12):1285-9. DOI:10.1038/sj.embor.7400831 | PubMed ID:17099691 | HubMed [2006ref6]

All Medline abstracts: PubMed | HubMed


  1. Abraham EG, Pinto SB, Ghosh A, Vanlandingham DL, Budd A, Higgs S, Kafatos FC, Jacobs-Lorena M, and Michel K. An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites. Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16327-32. DOI:10.1073/pnas.0508335102 | PubMed ID:16260729 | HubMed [2005ref1]
  2. Volz J, Osta MA, Kafatos FC, and Müller HM. The roles of two clip domain serine proteases in innate immune responses of the malaria vector Anopheles gambiae. J Biol Chem. 2005 Dec 2;280(48):40161-8. DOI:10.1074/jbc.M506191200 | PubMed ID:16188883 | HubMed [2005ref2]
  3. Vontas J, Blass C, Koutsos AC, David JP, Kafatos FC, Louis C, Hemingway J, Christophides GK, and Ranson H. Gene expression in insecticide resistant and susceptible Anopheles gambiae strains constitutively or after insecticide exposure. Insect Mol Biol. 2005 Oct;14(5):509-21. DOI:10.1111/j.1365-2583.2005.00582.x | PubMed ID:16164607 | HubMed [2005ref3]
  4. Sim C, Hong YS, Vanlandingham DL, Harker BW, Christophides GK, Kafatos FC, Higgs S, and Collins FH. Modulation of Anopheles gambiae gene expression in response to o'nyong-nyong virus infection. Insect Mol Biol. 2005 Oct;14(5):475-81. DOI:10.1111/j.1365-2583.2005.00578.x | PubMed ID:16164603 | HubMed [2005ref4]
  5. Michel K, Budd A, Pinto S, Gibson TJ, and Kafatos FC. Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei. EMBO Rep. 2005 Sep;6(9):891-7. DOI:10.1038/sj.embor.7400478 | PubMed ID:16113656 | HubMed [2005ref5]
  6. Meister S, Kanzok SM, Zheng XL, Luna C, Li TR, Hoa NT, Clayton JR, White KP, Kafatos FC, Christophides GK, and Zheng L. Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11420-5. DOI:10.1073/pnas.0504950102 | PubMed ID:16076953 | HubMed [2005ref6]
  7. Moita LF, Wang-Sattler R, Michel K, Zimmermann T, Blandin S, Levashina EA, and Kafatos FC. In vivo identification of novel regulators and conserved pathways of phagocytosis in A. gambiae. Immunity. 2005 Jul;23(1):65-73. DOI:10.1016/j.immuni.2005.05.006 | PubMed ID:16039580 | HubMed [2005ref7]
  8. Vlachou D, Schlegelmilch T, Christophides GK, and Kafatos FC. Functional genomic analysis of midgut epithelial responses in Anopheles during Plasmodium invasion. Curr Biol. 2005 Jul 12;15(13):1185-95. DOI:10.1016/j.cub.2005.06.044 | PubMed ID:16005290 | HubMed [2005ref8]
  9. Vlachou D and Kafatos FC. The complex interplay between mosquito positive and negative regulators of Plasmodium development. Curr Opin Microbiol. 2005 Aug;8(4):415-21. DOI:10.1016/j.mib.2005.06.013 | PubMed ID:15996894 | HubMed [2005ref9]
  10. Belyakin SN, Christophides GK, Alekseyenko AA, Kriventseva EV, Belyaeva ES, Nanayev RA, Makunin IV, Kafatos FC, and Zhimulev IF. Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories. Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8269-74. DOI:10.1073/pnas.0502702102 | PubMed ID:15928082 | HubMed [2005ref10]
  11. Xu X, Dong Y, Abraham EG, Kocan A, Srinivasan P, Ghosh AK, Sinden RE, Ribeiro JM, Jacobs-Lorena M, Kafatos FC, and Dimopoulos G. Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions. Mol Biochem Parasitol. 2005 Jul;142(1):76-87. DOI:10.1016/j.molbiopara.2005.02.013 | PubMed ID:15907562 | HubMed [2005ref11]
  12. Kriventseva EV, Koutsos AC, Blass C, Kafatos FC, Christophides GK, and Zdobnov EM. AnoEST: toward A. gambiae functional genomics. Genome Res. 2005 Jun;15(6):893-9. DOI:10.1101/gr.3756405 | PubMed ID:15899967 | HubMed [2005ref12]
  13. Michel K and Kafatos FC. Mosquito immunity against Plasmodium. Insect Biochem Mol Biol. 2005 Jul;35(7):677-89. DOI:10.1016/j.ibmb.2005.02.009 | PubMed ID:15894185 | HubMed [2005ref13]
  14. Hill CA, Kafatos FC, Stansfield SK, and Collins FH. Arthropod-borne diseases: vector control in the genomics era. Nat Rev Microbiol. 2005 Mar;3(3):262-8. DOI:10.1038/nrmicro1101 | PubMed ID:15703759 | HubMed [2005ref14]
  15. Danielli A, Barillas-Mury C, Kumar S, Kafatos FC, and Loukeris TG. Overexpression and altered nucleocytoplasmic distribution of Anopheles ovalbumin-like SRPN10 serpins in Plasmodium-infected midgut cells. Cell Microbiol. 2005 Feb;7(2):181-90. DOI:10.1111/j.1462-5822.2004.00445.x | PubMed ID:15659062 | HubMed [2005ref15]
  16. Hall N, Karras M, Raine JD, Carlton JM, Kooij TW, Berriman M, Florens L, Janssen CS, Pain A, Christophides GK, James K, Rutherford K, Harris B, Harris D, Churcher C, Quail MA, Ormond D, Doggett J, Trueman HE, Mendoza J, Bidwell SL, Rajandream MA, Carucci DJ, Yates JR 3rd, Kafatos FC, Janse CJ, Barrell B, Turner CM, Waters AP, and Sinden RE. A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses. Science. 2005 Jan 7;307(5706):82-6. DOI:10.1126/science.1103717 | PubMed ID:15637271 | HubMed [2005ref16]
All Medline abstracts: PubMed | HubMed


  1. Kafatos FC. Mouse biology at Monterotondo. Science. 2004 Nov 26;306(5701):1475. DOI:10.1126/science.306.5701.1475 | PubMed ID:15567837 | HubMed [2004ref1]
  2. Lycett GJ, Kafatos FC, and Loukeris TG. Conditional expression in the malaria mosquito Anopheles stephensi with Tet-On and Tet-Off systems. Genetics. 2004 Aug;167(4):1781-90. DOI:10.1534/genetics.104.028175 | PubMed ID:15342516 | HubMed [2004ref2]
  3. Osta MA, Christophides GK, Vlachou D, and Kafatos FC. Innate immunity in the malaria vector Anopheles gambiae: comparative and functional genomics. J Exp Biol. 2004 Jul;207(Pt 15):2551-63. DOI:10.1242/jeb.01066 | PubMed ID:15201288 | HubMed [2004ref3]
  4. Christophides GK, Vlachou D, and Kafatos FC. Comparative and functional genomics of the innate immune system in the malaria vector Anopheles gambiae. Immunol Rev. 2004 Apr;198:127-48. DOI:10.1111/j.0105-2896.2004.0127.x | PubMed ID:15199960 | HubMed [2004ref4]
  5. Vlachou D, Zimmermann T, Cantera R, Janse CJ, Waters AP, and Kafatos FC. Real-time, in vivo analysis of malaria ookinete locomotion and mosquito midgut invasion. Cell Microbiol. 2004 Jul;6(7):671-85. DOI:10.1111/j.1462-5822.2004.00394.x | PubMed ID:15186403 | HubMed [2004ref5]
  6. Osta MA, Christophides GK, and Kafatos FC. Effects of mosquito genes on Plasmodium development. Science. 2004 Mar 26;303(5666):2030-2. DOI:10.1126/science.1091789 | PubMed ID:15044804 | HubMed [2004ref6]
  7. Blandin S, Shiao SH, Moita LF, Janse CJ, Waters AP, Kafatos FC, and Levashina EA. Complement-like protein TEP1 is a determinant of vectorial capacity in the malaria vector Anopheles gambiae. Cell. 2004 Mar 5;116(5):661-70. DOI:10.1016/s0092-8674(04)00173-4 | PubMed ID:15006349 | HubMed [2004ref7]
  8. Kafatos FC and Eisner T. Unification in the century of biology. Science. 2004 Feb 27;303(5662):1257. DOI:10.1126/science.303.5662.1257 | PubMed ID:14988521 | HubMed [2004ref8]
  9. Abraham EG, Islam S, Srinivasan P, Ghosh AK, Valenzuela JG, Ribeiro JM, Kafatos FC, Dimopoulos G, and Jacobs-Lorena M. Analysis of the Plasmodium and Anopheles transcriptional repertoire during ookinete development and midgut invasion. J Biol Chem. 2004 Feb 13;279(7):5573-80. DOI:10.1074/jbc.M307582200 | PubMed ID:14627712 | HubMed [2004ref9]
  10. Srinivasan P, Abraham EG, Ghosh AK, Valenzuela J, Ribeiro JM, Dimopoulos G, Kafatos FC, Adams JH, Fujioka H, and Jacobs-Lorena M. Analysis of the Plasmodium and Anopheles transcriptomes during oocyst differentiation. J Biol Chem. 2004 Feb 13;279(7):5581-7. DOI:10.1074/jbc.M307587200 | PubMed ID:14627711 | HubMed [2004ref10]
All Medline abstracts: PubMed | HubMed



  1. Cantera R, Lüer K, Rusten TE, Barrio R, Kafatos FC, and Technau GM. Mutations in spalt cause a severe but reversible neurodegenerative phenotype in the embryonic central nervous system of Drosophila melanogaster. Development. 2002 Dec;129(24):5577-86. DOI:10.1242/dev.00158 | PubMed ID:12421699 | HubMed [2002ref1]
  2. Niaré O, Markianos K, Volz J, Oduol F, Touré A, Bagayoko M, Sangaré D, Traoré SF, Wang R, Blass C, Dolo G, Bouaré M, Kafatos FC, Kruglyak L, Touré YT, and Vernick KD. Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population. Science. 2002 Oct 4;298(5591):213-6. DOI:10.1126/science.1073420 | PubMed ID:12364806 | HubMed [2002ref2]
  3. Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Müller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, and Kafatos FC. Immunity-related genes and gene families in Anopheles gambiae. Science. 2002 Oct 4;298(5591):159-65. DOI:10.1126/science.1077136 | PubMed ID:12364793 | HubMed [2002ref3]
  4. Zdobnov EM, von Mering C, Letunic I, Torrents D, Suyama M, Copley RR, Christophides GK, Thomasova D, Holt RA, Subramanian GM, Mueller HM, Dimopoulos G, Law JH, Wells MA, Birney E, Charlab R, Halpern AL, Kokoza E, Kraft CL, Lai Z, Lewis S, Louis C, Barillas-Mury C, Nusskern D, Rubin GM, Salzberg SL, Sutton GG, Topalis P, Wides R, Wincker P, Yandell M, Collins FH, Ribeiro J, Gelbart WM, Kafatos FC, and Bork P. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science. 2002 Oct 4;298(5591):149-59. DOI:10.1126/science.1077061 | PubMed ID:12364792 | HubMed [2002ref4]
  5. Holt RA, Subramanian GM, Halpern A, Sutton GG, Charlab R, Nusskern DR, Wincker P, Clark AG, Ribeiro JM, Wides R, Salzberg SL, Loftus B, Yandell M, Majoros WH, Rusch DB, Lai Z, Kraft CL, Abril JF, Anthouard V, Arensburger P, Atkinson PW, Baden H, de Berardinis V, Baldwin D, Benes V, Biedler J, Blass C, Bolanos R, Boscus D, Barnstead M, Cai S, Center A, Chaturverdi K, Christophides GK, Chrystal MA, Clamp M, Cravchik A, Curwen V, Dana A, Delcher A, Dew I, Evans CA, Flanigan M, Grundschober-Freimoser A, Friedli L, Gu Z, Guan P, Guigo R, Hillenmeyer ME, Hladun SL, Hogan JR, Hong YS, Hoover J, Jaillon O, Ke Z, Kodira C, Kokoza E, Koutsos A, Letunic I, Levitsky A, Liang Y, Lin JJ, Lobo NF, Lopez JR, Malek JA, McIntosh TC, Meister S, Miller J, Mobarry C, Mongin E, Murphy SD, O'Brochta DA, Pfannkoch C, Qi R, Regier MA, Remington K, Shao H, Sharakhova MV, Sitter CD, Shetty J, Smith TJ, Strong R, Sun J, Thomasova D, Ton LQ, Topalis P, Tu Z, Unger MF, Walenz B, Wang A, Wang J, Wang M, Wang X, Woodford KJ, Wortman JR, Wu M, Yao A, Zdobnov EM, Zhang H, Zhao Q, Zhao S, Zhu SC, Zhimulev I, Coluzzi M, della Torre A, Roth CW, Louis C, Kalush F, Mural RJ, Myers EW, Adams MD, Smith HO, Broder S, Gardner MJ, Fraser CM, Birney E, Bork P, Brey PT, Venter JC, Weissenbach J, Kafatos FC, Collins FH, and Hoffman SL. The genome sequence of the malaria mosquito Anopheles gambiae. Science. 2002 Oct 4;298(5591):129-49. DOI:10.1126/science.1076181 | PubMed ID:12364791 | HubMed [2002ref5]
  6. Alphey L, Beard CB, Billingsley P, Coetzee M, Crisanti A, Curtis C, Eggleston P, Godfray C, Hemingway J, Jacobs-Lorena M, James AA, Kafatos FC, Mukwaya LG, Paton M, Powell JR, Schneider W, Scott TW, Sina B, Sinden R, Sinkins S, Spielman A, Touré Y, and Collins FH. Malaria control with genetically manipulated insect vectors. Science. 2002 Oct 4;298(5591):119-21. DOI:10.1126/science.1078278 | PubMed ID:12364786 | HubMed [2002ref6]
  7. Bagni C, Bray S, Gogos JA, Kafatos FC, and Hsu T. The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Mech Dev. 2002 Sep;117(1-2):265-8. DOI:10.1016/s0925-4773(02)00176-4 | PubMed ID:12204268 | HubMed [2002ref7]
  8. Blandin S, Moita LF, Köcher T, Wilm M, Kafatos FC, and Levashina EA. Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene. EMBO Rep. 2002 Sep;3(9):852-6. DOI:10.1093/embo-reports/kvf180 | PubMed ID:12189180 | HubMed [2002ref8]
  9. Rusten TE, Cantera R, Kafatos FC, and Barrio R. The role of TGF beta signaling in the formation of the dorsal nervous system is conserved between Drosophila and chordates. Development. 2002 Aug;129(15):3575-84. DOI:10.1242/dev.129.15.3575 | PubMed ID:12117808 | HubMed [2002ref9]
  10. Kafatos FC. A revolutionary landscape: the restructuring of biology and its convergence with medicine. J Mol Biol. 2002 Jun 14;319(4):861-7. DOI:10.1016/S0022-2836(02)00427-8 | PubMed ID:12079311 | HubMed [2002ref10]
  11. Dimopoulos G, Christophides GK, Meister S, Schultz J, White KP, Barillas-Mury C, and Kafatos FC. Genome expression analysis of Anopheles gambiae: responses to injury, bacterial challenge, and malaria infection. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8814-9. DOI:10.1073/pnas.092274999 | PubMed ID:12077297 | HubMed [2002ref11]
  12. Thomasova D, Ton LQ, Copley RR, Zdobnov EM, Wang X, Hong YS, Sim C, Bork P, Kafatos FC, and Collins FH. Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8179-84. DOI:10.1073/pnas.082235599 | PubMed ID:12060762 | HubMed [2002ref12]
  13. Dimopoulos G, Kafatos FC, Waters AP, and Sinden RE. Malaria parasites and the anopheles mosquito. Chem Immunol. 2002;80:27-49. DOI:10.1159/000058838 | PubMed ID:12058645 | HubMed [2002ref13]
  14. Lycett GJ and Kafatos FC. Anti-malarial mosquitoes?. Nature. 2002 May 23;417(6887):387-8. DOI:10.1038/417387a | PubMed ID:12024196 | HubMed [2002ref14]
  15. Zhang D, Dimopoulos G, Wolf A, Miñana B, Kafatos FC, and Winzerling JJ. Cloning and molecular characterization of two mosquito iron regulatory proteins. Insect Biochem Mol Biol. 2002 May;32(5):579-89. DOI:10.1016/s0965-1748(01)00138-2 | PubMed ID:11891134 | HubMed [2002ref15]
  16. Merrill CE, Riesgo-Escovar J, Pitts RJ, Kafatos FC, Carlson JR, and Zwiebel LJ. Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1633-8. DOI:10.1073/pnas.022505499 | PubMed ID:11792843 | HubMed [2002ref16]
  17. Bolshakov VN, Topalis P, Blass C, Kokoza E, della Torre A, Kafatos FC, and Louis C. A comparative genomic analysis of two distant diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. Genome Res. 2002 Jan;12(1):57-66. DOI:10.1101/gr.196101 | PubMed ID:11779831 | HubMed [2002ref17]
  18. Peter A, Schöttler P, Werner M, Beinert N, Dowe G, Burkert P, Mourkioti F, Dentzer L, He Y, Deak P, Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Klapper R, Janning W, Glover DM, Ashburner M, Bellen HJ, Jäckle H, and Schäfer U. Mapping and identification of essential gene functions on the X chromosome of Drosophila. EMBO Rep. 2002 Jan;3(1):34-8. DOI:10.1093/embo-reports/kvf012 | PubMed ID:11751581 | HubMed [2002ref18]
All Medline abstracts: PubMed | HubMed


  1. Vizioli J, Bulet P, Hoffmann JA, Kafatos FC, Müller HM, and Dimopoulos G. Gambicin: a novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12630-5. DOI:10.1073/pnas.221466798 | PubMed ID:11606751 | HubMed [2001ref1]
  2. Wang R, Zheng L, Touré YT, Dandekar T, and Kafatos FC. When genetic distance matters: measuring genetic differentiation at microsatellite loci in whole-genome scans of recent and incipient mosquito species. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10769-74. DOI:10.1073/pnas.191003598 | PubMed ID:11553812 | HubMed [2001ref2]
  3. Kafatos FC. The future of genomics. Mol Aspects Med. 2001 Jun;22(3):101-11. DOI:10.1016/s0098-2997(01)00003-6 | PubMed ID:11470138 | HubMed [2001ref3]
  4. Benos PV, Gatt MK, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demaille J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Miñana B, Kafatos FC, Bolshakov S, Sidén-Kiamos I, Papagiannakis G, Spanos L, Louis C, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister D, Campbell L, Henderson NS, McMillan PJ, Salles C, Tait E, Valenti P, Saunders RD, Billaud A, Pachter L, Glover DM, and Ashburner M. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. Genome Res. 2001 May;11(5):710-30. DOI:10.1101/gr.173801 | PubMed ID:11337470 | HubMed [2001ref4]
  5. Dobens LL, Martín-Blanco E, Martínez-Arias A, Kafatos FC, and Raftery LA. Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis. Development. 2001 May;128(10):1845-56. DOI:10.1242/dev.128.10.1845 | PubMed ID:11311164 | HubMed [2001ref5]
  6. Levashina EA, Moita LF, Blandin S, Vriend G, Lagueux M, and Kafatos FC. Conserved role of a complement-like protein in phagocytosis revealed by dsRNA knockout in cultured cells of the mosquito, Anopheles gambiae. Cell. 2001 Mar 9;104(5):709-18. DOI:10.1016/s0092-8674(01)00267-7 | PubMed ID:11257225 | HubMed [2001ref6]
  7. Gomulski LM, Pitts RJ, Costa S, Saccone G, Torti C, Polito LC, Gasperi G, Malacrida AR, Kafatos FC, and Zwiebel LJ. Genomic organization and characterization of the white locus of the Mediterranean fruitfly, Ceratitis capitata. Genetics. 2001 Mar;157(3):1245-55. DOI:10.1093/genetics/157.3.1245 | PubMed ID:11238408 | HubMed [2001ref7]
  8. Rusten TE, Cantera R, Urban J, Technau G, Kafatos FC, and Barrio R. Spalt modifies EGFR-mediated induction of chordotonal precursors in the embryonic PNS of Drosophila promoting the development of oenocytes. Development. 2001 Mar;128(5):711-22. DOI:10.1242/dev.128.5.711 | PubMed ID:11171396 | HubMed [2001ref8]
  9. Dimopoulos G, Müller HM, Levashina EA, and Kafatos FC. Innate immune defense against malaria infection in the mosquito. Curr Opin Immunol. 2001 Feb;13(1):79-88. DOI:10.1016/s0952-7915(00)00186-2 | PubMed ID:11154922 | HubMed [2001ref9]
  10. Giannoni F, Müller HM, Vizioli J, Catteruccia F, Kafatos FC, and Crisanti A. Nuclear factors bind to a conserved DNA element that modulates transcription of Anopheles gambiae trypsin genes. J Biol Chem. 2001 Jan 5;276(1):700-7. DOI:10.1074/jbc.M005540200 | PubMed ID:11016929 | HubMed [2001ref10]
All Medline abstracts: PubMed | HubMed


  1. Han YS, Thompson J, Kafatos FC, and Barillas-Mury C. Molecular interactions between Anopheles stephensi midgut cells and Plasmodium berghei: the time bomb theory of ookinete invasion of mosquitoes. EMBO J. 2000 Nov 15;19(22):6030-40. DOI:10.1093/emboj/19.22.6030 | PubMed ID:11080150 | HubMed [2000ref1]
  2. Catteruccia F, Nolan T, Loukeris TG, Blass C, Savakis C, Kafatos FC, and Crisanti A. Stable germline transformation of the malaria mosquito Anopheles stephensi. Nature. 2000 Jun 22;405(6789):959-62. DOI:10.1038/35016096 | PubMed ID:10879538 | HubMed [2000ref2]
  3. Danielli A, Loukeris TG, Lagueux M, Müller HM, Richman A, and Kafatos FC. A modular chitin-binding protease associated with hemocytes and hemolymph in the mosquito Anopheles gambiae. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7136-41. DOI:10.1073/pnas.97.13.7136 | PubMed ID:10860981 | HubMed [2000ref3]
  4. Dimopoulos G, Casavant TL, Chang S, Scheetz T, Roberts C, Donohue M, Schultz J, Benes V, Bork P, Ansorge W, Soares MB, and Kafatos FC. Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6619-24. DOI:10.1073/pnas.97.12.6619 | PubMed ID:10841561 | HubMed [2000ref4]
  5. Benos PV, Gatt MK, Ashburner M, Murphy L, Harris D, Barrell B, Ferraz C, Vidal S, Brun C, Demailles J, Cadieu E, Dreano S, Gloux S, Lelaure V, Mottier S, Galibert F, Borkova D, Minana B, Kafatos FC, Louis C, Sidén-Kiamos I, Bolshakov S, Papagiannakis G, Spanos L, Cox S, Madueño E, de Pablos B, Modolell J, Peter A, Schöttler P, Werner M, Mourkioti F, Beinert N, Dowe G, Schäfer U, Jäckle H, Bucheton A, Callister DM, Campbell LA, Darlamitsou A, Henderson NS, McMillan PJ, Salles C, Tait EA, Valenti P, Saunder RD, and Glover DM. From sequence to chromosome: the tip of the X chromosome of D. melanogaster. Science. 2000 Mar 24;287(5461):2220-2. DOI:10.1126/science.287.5461.2220 | PubMed ID:10731137 | HubMed [2000ref5]
  6. Kafatos FC. Policy forum: European policy. Interesting times--biology, European science, and EMBL. Science. 2000 Feb 25;287(5457):1401, 1403. DOI:10.1126/science.287.5457.1401 | PubMed ID:10722387 | HubMed [2000ref6]
  7. Hill F, Benes V, Thomasova D, Stewart AF, Kafatos FC, and Ansorge W. BAC trimming: minimizing clone overlaps. Genomics. 2000 Feb 15;64(1):111-3. DOI:10.1006/geno.1999.6106 | PubMed ID:10708525 | HubMed [2000ref7]
  8. Catteruccia F, Nolan T, Blass C, Muller HM, Crisanti A, Kafatos FC, and Loukeris TG. Toward Anopheles transformation: Minos element activity in anopheline cells and embryos. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2157-62. DOI:10.1073/pnas.040568397 | PubMed ID:10681436 | HubMed [2000ref8]
  9. Vizioli J, Bulet P, Charlet M, Lowenberger C, Blass C, Müller HM, Dimopoulos G, Hoffmann J, Kafatos FC, and Richman A. Cloning and analysis of a cecropin gene from the malaria vector mosquito, Anopheles gambiae. Insect Mol Biol. 2000 Feb;9(1):75-84. DOI:10.1046/j.1365-2583.2000.00164.x | PubMed ID:10672074 | HubMed [2000ref9]
All Medline abstracts: PubMed | HubMed