Hoatlin:Peter R.

1. Control of gene tx in Eukaryotes

• Genes and promoter
  • RNA polymerase/tx initiation complexes, etc
  • Tx factors and tx co-regulatory molecules
    • Co-activators (acetyl transferase)
    • Co-repressors (deacetylases, methylases, demethylases)
  • Basis of tx factors
    • • Families
      • Functions
        • Mechanism of activation and inhibition
        • Choose key examples (CREB, NFkB, nuclear receptor)
• Chromatin and transcription
  • Chromatin structure
  • Histones
  • Histone modification
    • • Closed and open chromatin
      • Silencing, developmental changes, acute changes
• Signal transduction pathways at the XX? of transcription

2. Regulation of mRNA processing

• • Splicing pathways and splicesome
  • Alternative RNA splicing, diversity of protein expression, etc

3. Regulation of mRNA stability/turnover/XXX?

• • Short and long lived mRNA
  • Classic examples-RNA binding patterns

4. The new world of RNA mediated gene regulation

• • Non-coding RNAs
  • Slicing and dicing, shRNA, siRNA
  • siRNA and XX?

5. Regulation of protein biosynthesis

6. Biodiversity of higher order chromatin structure and function

note potential overlap with CDB 622 Back to Main Page Hoatlin Lab