Hoatlin:BMB Course Descriptions

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Biochemistry & Molecular Biology

BCMB 601 Research
(credits TBA) any term.
BCMB 503/603 Thesis
(credits TBA) any term, advisor TBA.
BCMB 605 Reading and Conference
(credits TBA) any term. Topics TBA with appropriate instructors.
BCMB 605 Metals and Membranes Protein Journal Club
(1 credit) fall, winter, spring terms. Recent publications focused on biochemical and biophysical analysis of receptor-mediated signal transduction, ion-transport, and ligand-stimulated membrane protein trafficking will be discussed. In addition, this journal club will offer an overview of modern experimental approaches to the structure and function of membrane proteins, such as site-specific labeling, fluorescent spectroscopy, energy-transfer, EPR, and fluorescence photo bleaching recovery. Lutsenko.
BCMB 605 Molecular Parasitiology Journal Club
(1 credit) fall, winter, spring terms – course offered bi-weekly. Papers to be discussed will include recent studies on parasites or parasitic diseases, with an emphasis on the biochemical and molecular biology aspect of the research, whether this be structure-function, host-parasite interaction or biophysical chemistry. Ullman.
BCMB 605 (and CELL 605) Signal Transduction Journal Club
(1 credit) fall, winter, spring terms. Recent papers focusing on all aspects of signaling will be discussed, including but not limited to ligand-receptor interactions, receptor structure-function relationships, intracellular phosphorylation cascades, signal transmission into the nucleus, and gene regulation. The focus will be on linking biochemical and molecular mechanisms to physiological and pathological processes, including mechanisms of disease. Rotwein
BCMB 607 Department Seminar Series
(1 credit) fall, winter, spring terms. An opportunity to learn the latest research in Biochemistry and Molecular Biology. Weekly seminars are presented by local and visiting scientists. Hoatlin
BCMB 617 Topics in Advanced Biophysical Chemistry
(credits TBA) winter term alternate years. Current concepts and theoretical foundations in selected topics of biophysical chemistry presented as a laboratory. Suggested Prerequisites: BCMB 621and Physical Chemistry. Bächinger.
BCMB 619 The Molecular and Biochemical Basis of Disease
(1 credit) fall, winter, spring terms. Designed for 2nd year BMB students to hone their presentation skills, specifically, how to present scientific data clearly, concisely and accurately. Prerequisite: Limited to first year graduate students rotating in the Department of Biochemistry & Molecular Biology. Farrens
BCMB 620 Membrane Biochemistry
(2 credits) winter term alternate years beginning 2003-04. The composition of biological membranes and the functional aspects of their composition; models of membrane structure, membrane function, and mechanisms of membrane transport. Lutsenko & Farrens
BCMB 621 Biophysical Chemistry of Macromolecule
(4 credits) spring term, alternate years beginning 2003-04. Biophysical properties of macromolecules in solution and in crystalline state, including the physical basis of modern biochemical and biophysical methods and the underlying chemistry of the behavior of macromolecules. Suggested Prerequisite: Some undergraduate level Physical Chemistry. Farrens
BCMB 624 (and CELL 624) Advanced Topics in Signal Transduction
(2 credits) fall term. The focus will be on the latest advances in mechanisms of signaling in eukaryotes, with an emphasis on both normal cell functioning and mechanisms of disease. The lecture - discussion format will require active class participation. Rotwein, Maurer
BCMB 625 Advanced Molecular Biology: Topics and Methods in Modern Molecular Biology
(3 credits) Spring term. An advanced graduate course with an emphasis on the latest research from the primary literature along with in-depth presentation of the basic concepts of biochemistry and molecular biology. Topics will be chosen from areas of expertise among the Biochemistry and Molecular Biology faculty, including properties of nucleotides and nucleic acids, the composition and structure of eukaryotic chromatin, eukaryotic gene expression, DNA replication, RNA transcription, RNA splicing and metabolism, and protein translation. Prerequisites: instructor consent. Hoatlin & Thayer
BCMB 628 Protein Crystallography
(2 credits) winter term alternate years beginning 2003-04. This is an advanced level course that covers all aspects of macromolecular structure determination by x-ray crystallography. Topics to be discussed include protein crystallization; x-ray sources and detectors; crystal properties; x-ray diffraction; intensity data collection, processing and manipulation; structure factors; calculation of electron density; the phase problem; single and multiple isomorphous replacement; multiple wavelength anomalous dispersion; molecular replacement; phase improvement; introduction to direct methods and Laue diffraction; structure refinement; model assessment. Prerequisities: Physical Chemistry and instructor consent. Chapman.
Scientific Writing Class
This course is an in-depth professional science writing course open to all OHSU researchers. The writing program has two main elements: the weekly two-hour seminar and the weekly individual tutorial.

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