Gunawan:Ang Kok Siong
Chemical and Biological Systems Engineering Laboratory
4 Engineering Drive 4 Block E5 #B-05
National University of Singapore
Tel:+65 6516 7859
I work in the Gunawan Lab at National University of Singapore.
- 2006, B.Eng (Chem), National University of Singapore, Singapore.
- Parameter Estimation of Oscillatory Systems
Oscillatory behavior is exhibited by many biological systems. Examples these include the circadian rhythm and p53-mdm2 response to DNA damage. Such dynamical behavior is important and integral of a higher biological function, such as sleeping and feeding patterns (circadian rhythm) and DNA repair (p53-mdm2). To study these systems, in-silico models have been developed to aid in the analysis. However, the corresponding model parameters are usually chosen qualitatively such that the system to exhibit the general characteristics of experimental data. The focus of the research here is to facilitate reconciliation of the model with experimental data in a quantitative manner.