Guillaume Lesage

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Contact Info

Guillaume Lesage.TIF
  • Guillaume Lesage
  • University of Zurich

     Institute of Molecular Biology / Hemmi Lab
     Winterthurerstrasse 190
     8057 Zurich

Research interests

  • Virology
  • MicroRNAs

Current position

PhD Student in the Hemmi Lab, Institute of Molecular Biology, University of Zurich

  • Engineering of Oncolytic CRAds for Melanoma Treatment
  • Study on Potential miRNAs Encoded by Human Adenoviruses

Previous labs

Supervisors: Dr. J. Stitz, Prof. M. Fussenegger
Projects: Light-inducible gene regulation system / Engineering and pseudotyping of the Duck Hepatitis B Virus (DHBV)

Supervisor: Dr. M.-Q. Xu
Project: Protein transduction assays on eukaryotic cells

Supervisor: Dr. M.-Q. Xu
Projects: Mutagenesis study of the Ssp DnaB mini-intein / Catalytic RNA in RNAi production


  • Master Degree of Science in Biotechnology / Diplôme d’ingénieur en Biotechnologie / Diplôme d’Etude Approfondie (DEA) in Cellular and Molecular Biology

Ecole supérieure de Biotechnologie de Strasbourg (ESBS) (graduated September 2003 in Strasbourg, France)
Tri-lingual (French, English and German) Biotechnology Masters program emphasizing practical laboratory training

  • Diplôme d'études universitaires générales (DEUG) in Biology

Institut d'Ecologie Appliquée, Université catholique de l'Ouest (graduated August 2000 in Angers, France)


  1. Galgano A, Forrer M, Jaskiewicz L, Kanitz A, Zavolan M, and Gerber AP. Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system. PLoS One. 2008 Sep 8;3(9):e3164. DOI:10.1371/journal.pone.0003164 | PubMed ID:18776931 | HubMed [Paper3]
  2. Fluri DA, Kelm JM, Lesage G, Baba MD, and Fussenegger M. InXy and SeXy, compact heterologous reporter proteins for mammalian cells. Biotechnol Bioeng. 2007 Oct 15;98(3):655-67. DOI:10.1002/bit.21461 | PubMed ID:17461419 | HubMed [Paper2]
  3. Ding Y, Xu MQ, Ghosh I, Chen X, Ferrandon S, Lesage G, and Rao Z. Crystal structure of a mini-intein reveals a conserved catalytic module involved in side chain cyclization of asparagine during protein splicing. J Biol Chem. 2003 Oct 3;278(40):39133-42. DOI:10.1074/jbc.M306197200 | PubMed ID:12878593 | HubMed [Paper1]

All Medline abstracts: PubMed | HubMed


  • Former active member of the Swiss country board of YEBN (Young European Biotech Network): Part of the organizing team of the annual meeting 2004 in Zurich and part of the sponsor recruiting team from February 2005 to February 2006
  • Active participation in the ESBS Alumni Day 2005
  • Founding member of the MicroRNA Network Zurich (MiNZ)

Useful links

Ecole Sperieure de Biotechnologie de Strasbourg (ESBS)
Institute of Molecular Biology
Zurich Ph.D. Program in Molecular Life Sciences
New England Biolabs, Inc.
Young European Biotech Network