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first exons of enhancer-generated long noncoding RNAs (elncRNAs) elncRNAs / promoter-antisense long noncoding RNAs (pa-lncRNAs) pa-lncRNAs-dependent (cis-regulatory element) splice machinery activity /extragenic transcription modulation. 33767452

Osteoclast derivative lysosomal secretion-dependent proton (H+)/acid hydrolase mediated bone resorption/bone homeostasis. 33484199

caffeine-inducible telomerase reverse transcriptase (TERT) upregulation (mRNA/protein)-dependent cellular senescence and aging mitigation/telomere length extension/ 3720241

Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs 33497605

chromatin stability dynamics

central nervous system (CNS) specific Mitochondrial biogenesis/integrity 33415987

CNS, oligodendrocyte precursor cells differentiate into oligodendrocytes to wrap their plasma membranes around neuronal axons, generating mature neural networks with myelin sheaths according to spatial and temporal patterns

Thymic epithelial cells (TECs) centric T cell development; T cell receptor (TCR) repertoire/lineage differentiation. Medullary thymic epithelial cells (mTECs) dependent thymocyte selection/self-tolerance. 33817835


  • Compressional wave dependent central nervous system (CNS) development (hippocampal oxidative states/aminoacidergic neurotransmission) 33386696
  • ubiquitin-proteasome system Selective recognition
  • NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome multiprotein complex dependent pro-inflammatory cytokines IL-1β and IL-18/ gasdermin D-mediated pyroptotic cell death
  • microtubule (MT) asymmetric distribution dynamics; cell polarity, centrosome positioning, focal adhesion dynamics
  • Prion protein (PrP) adopts (a)helical conformation (PrPC) or (b) beta sheet-rich, misfolded conformation (PrPSc). PrPSc form can alter templating "infect" PrPC and transition to misfolded states.
  • Alternative lengthening of telomeres (ALT) dependent break-induced replication (BIR),
  • Local nuclear protein synthesis (LNPS) / local nuclear translation
  • progenitor cell epigenetic fate conversion
  • Diapause / adaptive inactivation / reversible transcription development/reversion suspension
  • Ciliogenesis /axonemal outer dynein arm (ODA)
  • Intrinsic quiescence
  • Pulmonary endothelial barrier
  • Pluripotent stem cell trophic support systems
  • Mevalonate pathway
  • Thymus microenvironment-specific naive T cell mechanistic growth and maturation
  • Innate immune complement system sequential protein cleavage cascade activation
  • Ribosome biogenesis/ubiquitin-coordinated ribosome assembly
  • Regulatory T cells (follicular regulatory T (Tfr) cells) prevent emergence of B cell-driven autoantibodies and IgE-mediated allergies
  • Nonpeptidergic signaling
  • Efferocytosis
  • Low-grade mitochondrial stress; ergogenic mitohormesis
  • Major histocompatibility complex class II molecule antigen processing (endosomal processing efficiency)/ presentation machinery
  • Stress; in vivo non-enzymatic glycan chemistry; sugars, lipids, protein substrate (protein glycation, glycoxidation, and lipoxidation)
  • methyl donor, S-adenosylmethionine (SAM)
  • Ca2+ microdomain formation dependent prime T cell activation
  • Symmetric cell division; genetic information/cytoplasmic content partitioning between daughter cells
  • virus-host interaction; post-entry virus trafficking, uncoating and nuclear import
  • DNA double-strand break (DSB) repair by homologous recombination, DNA ends are resected (cut out) to overhanging single-stranded DNA (ssDNA). Homologous recombination = intrinsic coupling of Nucleosome (chromatin component) eviction with DNA-end resection.
  • Ferroptosis = programmed cell death via cellular accumulation of lipid peroxidation and lipid reactive oxygen species (ROS)
  • Posttranscriptional regulation; proliferation / maturation
  • ribosomal peptidyl-tRNA
  • Genetic transcription initiation rate/ burst duration; nonlinear (global gene bursting kinetics) gene regulatory function/cooperative gene control.
  • Pyroptosis
  • conditional essential
  • NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome kinetics
  • Protein Myristoylation
  • eukaryotic mRNA biogenesis; RNA polymerase II (Pol II/transcription machinery) / spliceosome component pre-mRNA branch site(s)recognition
  • Ubiquitin turnover
  • Rapid eye movement sleep (REMS) favors neuronal plasticity, brain development and memory
  • Metabolic heterogeneity
  • Prion-chaperoning machinery
  • Sister chromatid cohesion
  • Basal signaling, efficacy, precoupling, and allostery in GPCRs
  • Molecular chaperones
  • Mechanosensitive collaboration
  • Chromosomal Instability
  • Alternative telomere lengthening dynamics
  • Sphingolipid and ether lipid signatures
  • Genotoxic stress
  • Steatosis
  • Synaptic Transmission
  • Centriole Biogenesis


  • Autophagy is a form of intracellular metabolic recycling
  • Autophagy /catabolic (anabolic?) pathway(s) self-nourishment/maintenance/cellular homeostasis.
  • Autophagic flux / protective autophagy
  • Amino acid deprivation-induced autophagy
  • Chaperone-mediated autophagy (CMA) proteostasis network componentry (protein quality control)
  • Extracellular vesicles (EVs); large EVs (l-EVs, or microvesicles) / small EVs (s-EVs, or exosomes)
  • Extracellular growth factor-dependent communicate to ion channel modulating to intracellular organellar/ lysosomal function
  • Isocaloric moderately high-fat diet (IHF) prolongs (stasis of) lifespan 33440166
  • Retrograde lysosome transport


  • Astrocytic lineage dependent pituitary amygdala hippocampus axis
  • ezrin-radixin-moesin (ERM) dependent plasma membrane-actin cytoskeleton apical structure/junction formation (i.e. microvilli)
  • Leukocyte extravasation
  • Regulatory T cell homeostasis
  • Enteroendocrine cells
  • Macrophage polarization
  • Trophoblast cells-> spiral artery remodeling in hemochorial placentation. trophoblast cell lineage development/ modulator of the syncytiotrophoblast lineage. Nutrients between the mother and the fetus during pregnancy is predominantly governed by the syncytiotrophoblast lining at the outer surface of the placental villi. Mechanisms of extrasencory syncytiotrophoblast nutrient status and support.


  • DNA demethylation / methylation
  • Epitranscriptomic mechanisms
  • Genome structural variation (SV) determinant quantitative trait/epitranscriptomic programming
  • Memory formation
  • progenitor network determinants
  • Nucleosome Remodeling


  • Endotoxemic mechanisms
  • Gram negative bacterial phylogenetic host/phage dependent evolutionary divergence (CRISPR/Cas systems)/genetic variance determines host response severity/trajectory
  • Intra-host (pleomorphic) anaerobic bacteria quorum sensing (QS) networks
  • Latency reservoirs
  • Periodontal disease (p gingivalis) dependent coronary artery endothelial dysfunction 33677586
  • Prokaryotic/viral stage-specific quorum sensing / Autoinduction / density; Epigenetic (host histone methylation) response
  • type I interferon (IFN-1) response
  • Viral immune evasion evolution trajectories
  • Viral entry genetic variance (entry glycan/glycoprotein tropism) preferential viral entry tropism determines immunopathogenic disease severity trajectory

Organelle/Sub Structures


  • Caffeine induces cAMP/PKA/AMPK signaling dependent mitochondrial fission.
  • Mitochondria are an autonomous/spatially segregated parallel functioning genome within eukaryotic nuclear genomic.
  • Mitochondria organizational genome unit = nucleoid = mitochondrial DNA (mtDNA) + architectural proteins.
  • Mitochondrial respiration; ATP, respiration generates biosynthetic precursors (ie aspartate)/ essential substrates for nucleotide synthesis.


Phase Separation

  • chromosome/chromatin architecture; phase-separation dependent sub cellular/sub nuclear structures
  • Nanocluster Reorganization
  • phase separation dependent exonuclease endonuclease catalytic regulation outer shell at the droplet periphery selective environment
  • CaRriers of the Trans-Golgi network to the cell Surface (CARTS)
  • spatial distinction interactomes

Vesicular Traffic

  • Ribonucleoprotein complex-dependent extracellular RNA (exRNAs)/ncRNA/miRNA extracellular vesicle (EV) assembly units transmission from systemic circulation to Central Nervous System (CNS) via blood-brain barrier (BBB) traverse.
  • mesenchymal stem cell exosomal derivatives trafficking
  • Microfilament/Microtubule dependent endosomal trafficking mechanisms
  • Urinary extracellular vesicle (uEVs) traffic/excretion