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Recent Lab Papers

Gilbert, N., Allan, J. (2001) Distinctive higher-order chromatin structure at mammalian centromeres. Proc Natl Acad Sci. 98, 11949-54.

Gilbert, N., Boyle, S., Sutherland, H., de Las Heras, J., Allan, J., Jenuwein, T., Bickmore, W.A. (2003) Formation of facultative heterochromatin in the absence of HP1. EMBO J. 22, 5540-50

Gilchrist, S., Gilbert, N., Perry, P., Bickmore, W. A. (2004) Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. Chromosome Res. 12, 505-16.

Gilbert, N., Boyle, S., Fiegler, H., Woodfine, K., Carter, N., Bickmore, W.A. (2004) The chromatin architecture of the human genome: gene-rich domains are packaged in open chromatin fibres. Cell. 118, 555-66

Jackson, M., Krassowska A, Gilbert N, Chevassut T, Forrester L, Ansell J, Ramsahoye B. (2004) Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol. 24, 8862-71.

Poot RA, Bozhenok L, van den Berg DL, Steffensen S, Ferreira F, Grimaldi M, Gilbert N, Ferreira J, Varga-Weisz PD. (2004) The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Nat Cell Biol. 6, 1236-1244.

Gilbert, N., Gilchrist, S., Bickmore, W.A. (2005) Chromatin organisation in the mammalian nucleus. Int. Rev. Cytol. 242, 283-336.

Gilchrist, S., Gilbert, N., Perry, P. Ostlund, C., Worman, H. J., Bickmore, W.A. (2004) Altered protein dynamics of disease associated lamin A mutants. BMC Cell Biology. 5, 46.

Gilbert, N., Ramsahoye, B. (2005) The relationship between chromatin structure and transcriptional activity in mammalian genomes. Brief. Funct. Genomic. Proteomic. 4, 129.

Sproul, D., Gilbert, N., Bickmore, W.A. (2005) The role of chromatin structure in regulating the expression of clustered genes. Nature Reviews Genetics. 6, 775-81.

Gilbert, N., Bickmore, W.A. (2006) The relationship between higher-order chromatin structure and transcription. Biochem Soc Symp.73, 59-66.

Gilbert, N., Thomson, I., Boyle, S., Allan, J., Ramsahoye, B, Bickmore, W.A. DNA methylation affects nuclear organisation, histone modifications and linker histone binding, but not chromatin fibre compaction. Manuscript submitted.