Higher Order Chromatin
We are a new lab working on mammalian high-order chromatin fibre structure. We are based at the Edinburgh Cancer Research Centre at The University of Edinburgh in the School of Molecular and Clinical Medicine. Our main goal is to understand the folding of the 30nm chromatin fibre (secondary level of chromaitn fibre folding) and how this packaging influences cellular processes such as gene transcription, chromosome condensation, and nuclear architecture. In addition we are investigating how secondary chromatin structure is altered in disease.
Here is some background about chromatin.
The lab is funded by the Wellcome Trust through a career development fellowship to Nick Gilbert