Dahlquist:COVID-19 Research Project

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Articles about ACE2 polymorphisms relating to severity of SARS-CoV-2 infections

Questions

  1. Can mutations in the ACE I/II gene reveal susceptibility to severity of SARS-CoV-2 infection?
  2. Are heightened levels of ACE2 expression in COVID-19 patients with pre-existing conditions a key factor in their increased disease severity?
  3. What epigenetic modifications occur to ACE2 throughout COVID-19 pathology? Can they be altered?
  4. How do epigenetic changes associated with aging result in higher expression of the ACE2 gene and thus lead to increased COVID-19 susceptibility?
  5. What role does the expression of the ACE2 D allele play in increasing severe COVID-19 outcomes among particular populations?
  6. Could mosaicism in XX females afford higher immunity to COVID-19 since the gene for ACE2 is carried on the X chromosome?
  7. What role does the genetically distinct activation loop of the SARS-CoV-2 S protein have on its transmission and pathogenicity?
    • What implications do the differences have on S protein interaction with human ACE II?

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