Cadence Tutorial

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Cadence Labs Synthetic Biology Tutorial

This page is to host discuss of the Cadence Research Laboratory's tutorial run by SynBERC scientists, Chris Anderson, Adam Arkin, John Dueber and Tanja Kortemme.

The first tutorial took place January 14, 2007. The purpose was simply to outline the current definition, status and challenges.


  • Molecular Design
    • Optimization of Proteins for Multiple Fitness Criteria: Humphris & Kortemme; "Design of Multi-Specificity in Protein Interfaces", PLoS Computational Biology 3(8): 1591-1604.
    • Review Article on Molecular Design of Protein Interfaces: Kortemme & Baker; "Computational design of protein–protein interactions", Current Opinion in Chemical Biology, Volume 8, Issue 1, February 2004, Pages 91-97.
    • Optimization Methods: Voigt et al., "Trading accuracy for speed: a quantitative comparison of search algorithms in protein sequence design", Journal of Molecular Biology, Volume 299, Issue 3, 9 June 2000, Pages 789-803; doi:10.1006/jmbi.2000.3758.