Biomod/2012/TeamSendaiVer.Y/Abstract

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<!-- ヘッダー --> <div id="Header"> <h1><img src="http://openwetware.org/images/7/79/Biomod2012w500.jpg" width="500" height="221" alt="TeamSendaiTop" /></h1> </div>

<!—トップメニュー --> <ul id="Topmenu"> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Abstract">Abstract</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Project">Project</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Experiment">Experiment</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Diary">Diary</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Team">Team</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Reference">Reference</a></li> </ul>

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<h2>Abstract</h2>

<p> &nbsp;All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes. A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell. Here, we decided to create a novel device with such a function. We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones. We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.

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<img src="http://openwetware.org/images/4/46/Format_D-Heart.jpg" alt="D-Heart" width="790" height="602"/>

<p> <strong>Selector</strong>: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one.</br> <strong>Gate</strong>: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor.</br> <strong>Membrane</strong>: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.</br> </p>

<h2>Movie</h2> <p>Coming soon</p>

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<!—フッターメニュー --> <ul id="Menu2"> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Abstract">Abstract</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Project">Project</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Experiment">Experiment</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Diary">Diary</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Team">Team</a></li> <li><a href="http://openwetware.org/wiki/Biomod/2012/TeamSendaiVer.Y/Reference">Reference</a></li> </ul>

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