BioControl:Week8

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Next meeting Friday, 2/9 at 9am in 114 Steele Topics In vitro transcriptional networks Reading 1. Construction of an in vitro bistable circuit from synthetic transcriptional switches Jongmin Kim, Kristin S White, Erik Winfree." <http://www.nature.com/msb/journal/v2/n1/pdf/msb4100099.pdf> Related Articles Seelig G, Soloveichik D, Zhang DY, and Winfree E. Enzyme-free nucleic acid logic circuits. Science. 2006 Dec 8;314(5805):1585-8. DOI:10.1126/science.1132493 | Discussion It is possible to create in vitro biosynthetic logic circuits utilizing DNA and enzymes. In the next meeting we will overview the basic mechanisms and a few specific examples. Several questions come along when analyzing such systems, such as how to obtain modularity, predictable behaviors and robustness.