BME100 f2013:W900 Group12 L1
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LAB 1 WRITE-UP
Independent and Dependent Variables
The independent variable is the level of the inflammation inducing agent (lipopolysaccharide) used. The dependent variable is the amount of inflammatory protein (inflammotin) in the subject's blood.
Six groups will be created, each taking a different dose of the same inflammation inducing drug. Starting from 0mg, each successive group will have a larger dose of the drug, in increments of 2mg, until 10mg. Each group will have ten people, making for a total of 60 people.
0 mg pill: 10 people 2 mg pill: 10 people 4 mg pill: 10 people 6 mg pill: 10 people 8 mg pill: 10 people 10 mg pill: 10 people
(Discuss considerations of how subjects are to be selected.)
Sources of Error and Bias
The potential sources of error/bias include all of the following:
Participants who have pre-existing medical conditions will have increased chance of side effects from the inflammation inducing agent. This could cause more medical problems unrelated to inflammation. Results from the experiment could be affected by the presence of pre-existing health concerns. In accordance with this fact, we will choose subjects who do not have pre-existing medical conditions.
2. Previous medications taken by subjects that could affect inflammation inducing agent (lipopolysaccharide)
Other medications can have adverse effects on the results of the inflammation inducing agent. Other types of medication could react with the ingredients of the lipopolysaccharide and also affect inflammation in the body. The results will included both the previous medication's effect and the lipopolysaccharide. Therefore, we will ensure that our subjects do not take other medications prior to the experiment.
3. The lack of diversity in the demographic of subjects taken from retirement homes in specific areas
Because we are choosing subjects from retirement homes in specific areas of the state, we run into the issue that our sample does not represent the population well. To combat this possible source of error, we will visit three different retirement homes in different parts of the state in order to boost diversity among subjects.
4. Ability of subjects to take the proper amounts of the drug at the right times
We cannot ensure that our subjects will stick to our drug regimen. Therefore, we will trust nurses at the retirement homes to properly administer drug dosages at the right times of the day to the proper subjects.