Difference between revisions of "Biomod/2011/Harvard/HarvarDNAnos"

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Revision as of 22:02, 30 October 2011

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Home              Mission              Process              Designs              Results              Resources              Team


Hdna 2011 logo1.png

DNA Origami Containers

Previous work has showcased the use of scaffolded DNA origami to self-assemble nanoscale, three-dimensional shapes with enclosed, hollow interiors. We explore the possibility of using such structures to load, entrap, and release soluble nanoscale cargo, with potential future applications in drug delivery and molecular signal amplification. Specifically, we design a rectangular box structure that can encapsulate gold nanoparticles and subsequently release them by a two-step process: a) photocleavage, which solubilizes the nanoparticle within the box, and b) introduction of a DNA signal, which opens the box by strand-displacement. We further investigate the use of an existing spherical origami design for similar purposes, and demonstrate opening of the sphere.

Video

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Thank you

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