Difference between revisions of "AhmadWeek5"

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[http://pathway.yeastgenome.org/YEAST/NEW-IMAGE?type=PATHWAY&object=PWY3O-13&detail-level=3 Pathway Image Source]
[http://www.kegg.jp/kegg-bin/show_pathway?sce00250 Pathway Image Source]
{{Salman Ahmad}}
{{Salman Ahmad}}

Revision as of 20:11, 14 February 2013

Saccharomyces Genome Database

  1. Which of these genes has a homolog (similar gene related by descent) in humans? What disease does a deficiency of this gene cause in humans?
    • GDH2; the homologs are GLUD1 and GLUD2. "Deficiencies in the human homologs of glutamate dehydrogenase, GLUD1 and GLUD2, have been linked to hyperinsulinism-hyperammonemia syndrome and various neurological disorders." GDH2
  2. How is the expression of each of these genes regulated?
    • GDH1- Expression is "regulated by nitrogen and carbon sources" GDH1
    • GDH3- Expression is "regulated by nitrogen and carbon sources" GDH3
    • GDH2- Expression is "sensitive to nitrogen catabolite repression and intracellular ammonia levels" GDH2
    • GLN1- Expression is "regulated by nitrogen source and by amino acid limitation" GLN1
    • GLT1- Expression is "regulated by nitrogen source" GLT1
  3. "L-glutamate". How many pathways does it participate in?
    • It is in reactions as a reactant 26 times. It is in reactions as a product 29 times. L-glutamate

LglutamatePathway.gif Pathway Image Source


KeggPathway.jpg Pathway Image Source


Useful links