Griffin:Trending

2024

2023

Pangenomics; population-level genome reference structures PMID: 36646895

inflammatory dependent epigenetic memory programs interferon response resistance PMID: 36646856

Cell lineage reprogramming = ibroblasts can be reprogrammed into induced trophoblast stem (iTS) cells by transcription factor-mediated nuclear reprogramming using the Yamanaka factors OCT4, KLF4, SOX2 and c-MYC (OKSM) and a selection of TS cell culture conditions. 36241724

3D cultures = incorporating viscoelasticity into 3D for better Glioblastoma multiforme (GBM) modeling 36239185

CellREADR (Cell access through RNA sensing by Endogenous ADAR), a programmable RNA-sensing technology that leverages RNA editing mediated by ADAR to couple the detection of cell-defining RNAs with the translation of effector proteins 36198803

pathology protection mechanistic overide begets proliferation and promotion. 36198802

Intestinal Antimicrobial granules ;Paneth cells PMID: 36198790

super-enhancers/ master regulatory hubs control cell identity and pluripotency(SE-SOX2, SE-PIM1, and SE-FGFR1 pluripotency-dependent pluripotency-associated regula- tory networks in mammals. 36161929

parent cells to daughter cells chromatin state transmission (cell-specific transcriptional signatures/cell identity (H3K27me3) through cell division. transgenerational epigenetic inheritance 36161922

How did Saturn get its rings? 36107998

Obesity pan tropic effect (female fertility) 36096447

viral (HIV) integration bias toward methylated histone core Loci 36094316

TPRX transcription factor family leverages oocyte-to-embryo transition (36074823)

Senescence in maturation overabundance (human adipose) = inflammation risk (T2D, Obesity) 36006465

RNA-guided DNA methylation 35762252

Host genetic resistance endogenous retrovirus (ERV) soluble retroviral envelope (genes) proteins suppress retroviral infection by competing for entry protein binding (blocking) Endogenous domesticated retroviruses (ERVs) PMID: 35749360

Endogenous retroviruses (ERVs) are remnants of ancestral viral infections of cells and occupy substantial proportions of mammalian genomes. Most ERVs have numerous mutations, deletions, and insertions in the coding region; truncated envelope (env) genes are scattered throughout the genomes. The truncated Envelope (Env) proteins consist of a signal peptide and the N-terminal region of the surface unit, but they lack a transmembrane domain; these proteins are secreted from cells in soluble form and block viral infection via competition with entry receptors. 35749360

Mechano-sensory (applied forces) transduction to nuclear space 35681009

ex vivo engineered B cell transplantation (in vivo) driven immunity 35681059

Mesenchymal stem cells (MSCs) are adherent, fibroblast-like, nonhematopoietic progenitor cells, present in a variety of human tissues, including bone-marrow (BMMSC), adipose tissue (ASC), umbilical cord (UCMSC), gin-giva (GMSC), cartilage tissue (CMSC), skin tissue (SSC), dental pulp (DPSC),

Metabolism of endogenous retroviral element (EREs) derived immunogenic double-stranded RNAs (dsRNAs) immune checkpoint blockade (ICB)-based monotherapies 35614224

Prokaryotic translation Bacterial ribosome identifies a typical translation initiation site from mRNA. 35605125

T Cell Expansion / Myeloprolioferative

EMT Epithelial-Mesenchymal transition

viral mimicry (Reverse Transcriptase) inhibition of RNA expression of repetitive sequences and retrotransposition elements disrupts cancer progression 35320348

Non-genetic determinants of clonal fitness 34880496

Loss of epigenetic regulators accelerated tumorigenesis 36108220

alphaherpesvirus neuroinvasive mechanistic 34789877

miRNA driven Exosome/extracellular vesicle (EV) programs 34937935

fetomaternal tolerance; glycan biology non-immunogenic placental self recognition PMID: 35236989

cancer targeting therapeutic microbes expressing (focused) ultrasound (hyperthermia)-inducible immune checkpoint inhibitors 35332124

Cryopreservation 35338396

intergenerational transmission of learning and memory performances PMID: 35502983

2022

Epigenetic inheritance Transcriptional memory read-write propagation 34782763

protease inhibiting DNA nanodevices boost tumour-associated macrophages (TAMs) ability to antigen represent 34764452

96-well plate high throughput recombinant hgh detection 34761559

rRNA 2′-O-methylation differential 2′-O-methylation of ribosomal RNA (rRNA) 34759377

protein Ubiquitination dependent Stress granule network (RNA / Protein vesicular condensates) disassembly. 34739333

cancer metastasis by stimulating exosome secretion 34727291

RNA-bound proteome (RNA interactome) 34697467

Human epithelial organoids—3D spheroids for investigation of epithelial physiology 34663962

DNA deaminase mutator activity + CRISPR-Cas localization = Controllable genome editing 34663942

immunopeptidome 34663921

pan-serotype dengue virus inhibitor nature 34616043

autophagy attenuates ribosomal DNA velocity 34612149

transcription mechanisms are phase separation dependent 34605568

noncoding RNA networks LINC00664/miR-411-5p 34582069

elevated aerobic capacity is associated with greater oxidative damage and higher costs of protein turnover. 34581401

chromatin architecture 34556886

Axis - Reciprocal transcription factor networks 34556884

Therapeutic Human Bone Marrow Mesenchymal Stem Cell–Derived Exosomes 34554399 Extrachromosomal DNA

transcription independent feedback regulation (variable-gain stochastic pooling) 34301608

methylated retrotransposons 34326545

Chromatin Landscapes (Epigenetics)

OCT4 targeting (binding) nucleosomes (high density chromatin) pluripotency 34354236

Chromatin occupancy after replication (ChOR)-seq and sister chromatids after replication (SCAR)-seq 34363071

ergogenic/antibacterial Colostrum 34398472

polyD/E ATP-independent molecular chaperones, disaggregases and unfoldases 34408321

neuro-mesenchymal long-range neuronal circuitry 34408322

Dietary fructose 34408323

pathogen- or damage-associated molecular pattern (PAMP or DAMP, respectively) 34471287

esophageal ion transport organoid 34524930

Entosis nonphagocytic cell-in-cell (CIC) interaction where a living cell enters into another.

Autophagy is a self-phagocytic and highly evolutionarily conserved intracellular lysosomal catabolic system, which plays a vital role in a variety of trauma models, including skin wound healing (SWH).34547141

dual size/charge- transformable, Trojan-Horse nanoparticle (pPhD NP) for delivery of ultra-small, full active pharmaceutical ingredients (API) nanotheranostics with integrated dual-modal imaging and trimodal therapeutic functions.

Metabolic Reprogramming Drives Stemness 34172498

Deaminase fused-Cas9 base editing 34172975

ECM Stiffness Regulates DNA Methylation 34174172

CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being associated with ~70% of all gene promoters. CGIs control transcription initiation by conferring nearby promoters with unique chromatin properties 34183853

methylation / histone H3 at lysine 9 (H3K9me2) is an important epigenetic modifier of embryonic development, cell reprogramming and cell differentiation 34184085

The most prevalent post-transcriptional mRNA modification, N6-methyladenosine (m6A), plays diverse RNA-regulatory roles, 34211177

N6-Methyladenosine-Based Epitranscriptomic Mechanism 34213887

gut microbiota (gut-brain axis) neural basis of contribution to social activity 34194038

H3R2 methylation Histone methylation dependent small nuclear RNA (snRNA) driven RNA splice variation 34196368

Chromatin remodeling complexes alter chromatin structure 34197713

Fasting promotes microbiota health 34227218

Expansion microscopy (ExM) expanding sample swellable hydrogel. 34228783

increasing basement membrane stiffness recapitulates age-related hair follicle SCs 34239060

Human Dental Pulp Stem Cell Spheroids Differentiation 34241992

increase in fertilizability of frozen-thawed spermatozoa 34245495

CCCTC-binding factor (CTCF) protein binding dependent topologically associating domain (TAD) spatial environment 34245617

N1-methyladenosine (m1A), N3-methylcytidine (m3C), N1-methylguanosine (m1G) and N2,N2-dimethylguanosine (m22G) modifications simultaneously within all cellular RNA 34253897

Selective autophagy host defense 34257412

ergogenic hypoxia 34261659

exercise enhances brain lysosomal function 34272505

gastric organoid model 34272617

Physical exercise plasma boosts memory Glenn Center for the Biology of Aging muscle organoid 34880498

Intrinsically disordered regions (IDRs) in proteins are often targets of combinatorial posttranslational modifications 34158397

miR-429/PD-L1 Axis 33555514

N6-methyladenosine (m6A) is the most prevalent posttranscriptional modification on RNA.

O-GlcNAc (short for O-linked GlcNAc or O-linked β-N-acetylglucosamine) is a reversible enzymatic post-translational modification that is found on serine and threonine residues of nucleocytoplasmic proteins

younger age and a high number of tumor-infiltrating lymphocytes were predictive factors of a good response to immune checkpoint inhibitors 34136945

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth 34168367

lymphoid lineage maturation bottleneck 34170284

HeLa Cells are heterogeneic/mixed population 34076552

base-pair resolution genome architecture 34108683

semiallogeneic (fetal) development dependent immuno-modulation (suppression) 34099889

enhancement (solid mass) targeting CAR(T) 34083764

host lineage quorum sensing (immunity) 34124789

body mass (adipose) dependent epigenetic modulation 32500354

Coffee consumption improves cognitive function 33125576

Autophagy (Mitophagy) promotes stemness 33172301

Exosome detection method via the ultrafast-isolation system (EXODUS) that allows automated label-free purification of exosomes from varied biofluids/ exosomal RNA profiling 33432243

Periodontal inflammation dependent neuropathology 33432590

Poly Adenylation trait loci mapping 33986536

ex vivo (transplantable cell populations) prime editing 33951479

hippocampal-thalamic-cortical network dependent systems consolidation (remote memory retrieval) 33782621

organoid engineering hPSC cardiac 33772245

3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs) / polyadenylation quantitative trait loci 33986536

Genomic stability; DNA repair dependent genomic integrity / immune (hemopoietic) system (T Cell response) aging dynamics 33981041

RNA transcript dependent Homologous recombination (HR) DNA double-strand break (DSB) Repair 33981036

isoform composition of mRNA transcription dynamics splice site (intron/exon) selection 33979654

microbiota mutualist species fitness; interspecific dynamics of host-control 33521949

Intergenic Nonprotein Coding RNA 33978457

N6-Methyladenosine (m6A) dependent Spatial Patterning 33972392

nanoparticles water-insoluble hydrophobic polyethylenimines, low-molecular weight (MW) polyethylenimine (PEI) with high cholesterol substitution water-insoluble polymers RNAi vehicles 33964112

fate, migration, proliferation, progression 33971280

SF9 / baculovirus eukaryotic expression 0.3-8 mg/Liter yield 33971243

exogenic xenotransplantation 33782573

Mesenchymal fibro-adipogenic progenitor (FAP) stemness differentiation to skeletal muscle regeneration/repair 33529374

skeletal muscle ribosomal capacity

Stress/trauma exposure driven epigenomic (DNA methylation (DNAm)/ differentially methylated regions (DMR)) current 33529416

deep time metazoan global phylogeny

viral phylogenetics 33972780

miR-351-3p dependent mesenchymal stromal cell proliferation 33970551

genomic DNA promoter intrastrand hairpin (cruciforms)/ four-strand (G-quadruplex or i-motif) structures 33931265

Inflation (stem cell/transcriptional differentiation)-collapse (stretch-responsive/mechanical) dynamics / Inflation-collapse morphogenesis dynamics 33915079

BCAAs Isoleucine increases muscle mass 33289736

Therapeutic Intervention

platelets thrombosis Factor cascade 33471623

proteomics/kinome screen re: gluconeogenesis 33951476

Goat Milk 33555137

Heme catabolism 33903766

extracellular vesicle Proteomics 33905554

Ketone bodies are generated in the liver and allow for the maintenance of systemic caloric and energy homeostasis during fasting and caloric restriction. 33619377

genome-wide association study (GWAS) risk association Alzheimer’s disease (BIN1) and Parkinson’s disease (TMEM175) / GBA, APOE and SNCA 33589841

retrosplenial cortex (RSC) to dorsal hippocampus axis 33580135

Ferroptosis, redox lipid death signal 33542532

genome-wide association study (GWAS) risk association Alzheimer’s disease (BIN1) and Parkinson’s disease (TMEM175) / GBA, APOE and SNCA 33589841

retrosplenial cortex (RSC) to dorsal hippocampus axis 33580135

miR-138 dependent viral latency 33558653

adolescent stress dependent neuroimmune transcriptinomic modification (stress dependent epigenetic memory) 33558677

chromatin density; four major families of nucleosome remodeler complexes in mammals (SWI/SNF (switch/sucrose non-fermentable), ISWI (imitation switch), CHD (chromodomain helicase DNA binding) and INO80) are protein assemblies of a catalytic ATPase plus accessory subunits. 33558757

Ferroptosis, redox lipid death signal 33542532

neuronal metastable proteome autophagy stasis 33891876

Melatonin 31894324

Processing bodies (P-bodies) 33586867

TRAFTACs: TRAnscription Factor TArgeting Chimeras (HaloTag-fused dCas9) 33836141

ncRNA autocrine/paracrine 33345445

SUMOylation 33526451

Epithelial mesenchymal Transition 33517270

comparative proteomics / host antiviral viral replication systems 33432153

epigenetic histone H3 methylation upstream 33900313

innate immune system response / transmembrane pores maturation / mechanistic cytokine release 33883744

Behavioral /mate choice-dependent niche (speciation) reinforcement 33766854

NGS based Tick-Borne Bacterial 16S Ribosomal RNA Detection from Whole Blood 33627320

human telomerase 33883742

Proinflammatory cytokine x homeostatic cytokine axis 33859404

recombinant multivalent hyperimmune globulins 33859400

pathogen exposure dependent polygenic shift adaptation 33854233

Multipotent adult progenitor cells (MAPC® cells) 33655577

Ubiquitin-dependent endosomal / lysosomal pathway coordination 33650289

Coconut Oil Supplementation inflammatory / dysfunction risk 33650755

Static magnetic field (SMF), with constant magnetic field strength and direction 2-4 T SMF improved bone microarchitecture and strength by stimulating bone formation and restraining bone resorption 33655538

photoreceptor-like Retinal organoids (ROs) 33662144

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness 33290722

systemic lipopolysaccharide (LPS) morbidity 33677747

human primordial germ cell-like cells (hPGCLCs) expansion and epigenetic reprogramming 32954504

mesenchymal stromal/stem cell (MSC) support of astrocytic response 33381863

differentiation state specific Expression quantitative trait loci (eQTL) (genetic) variant trait-association 33664506

Phenotypic reversion / Donor cell memory 33848472

Nuclear mechanosensing 33875841

TNF-α dependent thiamin uptake abrogation

Peptide-major histocompatibility complex (pMHC) multimers enable the detection of antigen-specific T cells 33649568

Glucocorticoids are adrenocortical hormones maintaining homeostasis, including regulating whole-body energy metabolism in addition to stress response. In skeletal muscle, glucocorticoids can reduce the synthesis of muscle proteins and simultaneously accelerate the breakdown of proteins to regulate skeletal muscle mass and energy metabolism

caffeine-inducible telomerase reverse transcriptase (TERT) upregulation (mRNA/protein)-dependent cellular senescence and aging mitigation/telomere length extension/ 3720241

differentiation dependent gene transcription; initiation, promoter-proximal pausing, RNA polymerase II (Pol II) elongation. 33539786

Transit-amplifying cells (TACs) tissue-cell-type composition renewal via potentiating proliferative progenitor and specialization/ differentiated cell production emanation 33484640

Transit-amplifying cells (TACs) are an undifferentiated population in transition between SCs and differentiated cells. 24813615

Microglia are activated in many neurological diseases (systemic inflammation) and have been suggested to play an important role in the development 33476547

RNA signaling; ~150 post-transcriptional RNA modifications have been identified in all kingdoms of life. N6-methyladenosine (m6A) (epigenetic RNA feature), is a ligand for human adenosine A3 receptor (> affinity than unmodified adenosine) 33472058

basophil-neuronal axis 33450207

2021

Compressional wave dependent central nervous system (CNS) development (hippocampal oxidative states/aminoacidergic neurotransmission) 33386696
ubiquitin-proteasome system Selective recognition
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome multiprotein complex dependent pro-inflammatory cytokines IL-1β and IL-18/ gasdermin D-mediated pyroptotic cell death
microtubule (MT) asymmetric distribution dynamics; cell polarity, centrosome positioning, focal adhesion dynamics
Prion protein (PrP) adopts (a)helical conformation (PrPC) or (b) beta sheet-rich, misfolded conformation (PrPSc). PrPSc form can alter templating "infect" PrPC and transition to misfolded states.
Alternative lengthening of telomeres (ALT) dependent break-induced replication (BIR),
Local nuclear protein synthesis (LNPS) / local nuclear translation
progenitor cell epigenetic fate conversion
Diapause / adaptive inactivation / reversible transcription development/reversion suspension
Ciliogenesis /axonemal outer dynein arm (ODA)
Intrinsic quiescence
Pulmonary endothelial barrier
Pluripotent stem cell trophic support systems
Mevalonate pathway
Thymus microenvironment-specific naive T cell mechanistic growth and maturation
Innate immune complement system sequential protein cleavage cascade activation
Ribosome biogenesis/ubiquitin-coordinated ribosome assembly
Regulatory T cells (follicular regulatory T (Tfr) cells) prevent emergence of B cell-driven autoantibodies and IgE-mediated allergies
Nonpeptidergic signaling
Efferocytosis
Major histocompatibility complex class II molecule antigen processing (endosomal processing efficiency)/ presentation machinery
Stress; in vivo non-enzymatic glycan chemistry; sugars, lipids, protein substrate (protein glycation, glycoxidation, and lipoxidation)
methyl donor, S-adenosylmethionine (SAM)
Ca2+ microdomain formation dependent prime T cell activation
Symmetric cell division; genetic information/cytoplasmic content partitioning between daughter cells
virus-host interaction; post-entry virus trafficking, uncoating and nuclear import
DNA double-strand break (DSB) repair by homologous recombination, DNA ends are resected (cut out) to overhanging single-stranded DNA (ssDNA). Homologous recombination = intrinsic coupling of Nucleosome (chromatin component) eviction with DNA-end resection.
Ferroptosis = programmed cell death via cellular accumulation of lipid peroxidation and lipid reactive oxygen species (ROS)
Posttranscriptional regulation; proliferation / maturation
ribosomal peptidyl-tRNA
Genetic transcription initiation rate/ burst duration; nonlinear (global gene bursting kinetics) gene regulatory function/cooperative gene control.
Pyroptosis
conditional essential
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome kinetics
Protein Myristoylation
eukaryotic mRNA biogenesis; RNA polymerase II (Pol II/transcription machinery) / spliceosome component pre-mRNA branch site(s)recognition
Ubiquitin turnover
Rapid eye movement sleep (REMS) favors neuronal plasticity, brain development and memory
Metabolic heterogeneity
Prion-chaperoning machinery
Sister chromatid cohesion
Basal signaling, efficacy, precoupling, and allostery in GPCRs
Molecular chaperones
Mechanosensitive collaboration
Chromosomal Instability
Alternative telomere lengthening dynamics
Sphingolipid and ether lipid signatures
Genotoxic stress
Steatosis
Synaptic Transmission
Centriole Biogenesis

Autophagy

neuronal metastable proteome autophagy stasis 33891876
caloric restriction (CR) metabolomic, transcriptomic, proteomic signatures 33421383
Selective autophagy (aggnephagy) proteostasis; clearing accumulation and aggregation of ubiquitinated proteins. 33545068
Macroautophagy lysosome-mediated degradation
Autophagy is a form of intracellular metabolic recycling
Autophagy /catabolic (anabolic?) pathway(s) self-nourishment/maintenance/cellular homeostasis.
Autophagic flux / protective autophagy
Amino acid deprivation-induced autophagy
Chaperone-mediated autophagy (CMA) proteostasis network componentry (protein quality control)
Calorie restriction (CR) exerts multiple effects on health,including the amelioration of systemic insulin resistance.
Extracellular vesicles (EVs); large EVs (l-EVs, or microvesicles) / small EVs (s-EVs, or exosomes)
Extracellular growth factor-dependent communicate to ion channel modulating to intracellular organellar/ lysosomal function
Isocaloric moderately high-fat diet (IHF) prolongs (stasis of) lifespan 33440166
Retrograde lysosome transport
liver derivative ketone bodies /systemic caloric,energy homeostasis during fasting and caloric restriction. 33619377

Lineage/Differentiation

stemness dependent exosomal trafficking of miRNA 33945431
cis-regulatory element spatial cue dependent cell fate commitment/molecular identity determination 33852891
stromal differentiation 33658717
3D organoid culture technology ; Human induced pluripotent stem cells (iPSCs) to studies of organ development, disease modeling, drug screening and cell replacement therapy.
Astrocytic lineage dependent pituitary amygdala hippocampus axis
CNS, oligodendrocyte precursor cells differentiate into oligodendrocytes to wrap their plasma membranes around neuronal axons, generating mature neural networks with myelin sheaths according to spatial and temporal patterns
ezrin-radixin-moesin (ERM) dependent plasma membrane-actin cytoskeleton apical structure/junction formation (i.e. microvilli)
Hematopoietic stem cell (HSCs) systemic (re)entry/replenishment cell cycle program initiation
Leukocyte extravasation
Osteoclast derivative lysosomal secretion-dependent proton (H+)/acid hydrolase mediated bone resorption/bone homeostasis. 33484199
Regulatory T cell homeostasis
Enteroendocrine cells
Macrophage polarization
Thymic epithelial cells (TECs) centric T cell development; T cell receptor (TCR) repertoire/lineage differentiation. Medullary thymic epithelial cells (mTECs) dependent thymocyte selection/self-tolerance. 33817835
Trophoblast cells-> spiral artery remodeling in hemochorial placentation. trophoblast cell lineage development/ modulator of the syncytiotrophoblast lineage. Nutrients between the mother and the fetus during pregnancy is predominantly governed by the syncytiotrophoblast lining at the outer surface of the placental villi. Mechanisms of extrasencory syncytiotrophoblast nutrient status and support.
trophoblastic lineage; BeWo, JEG-3, HTR-8/SVneo, AC1-M59, AC1-M32, ACH-3P and Swan71
Sequential myeloid transition
viability nascency enhancement; Human pluripotent stem cells (hPSCs) chroman 1, emricasan, polyamines, and trans-ISRIB (CEPT) enhanced cell survival of genetically stable hPSCs by simultaneously blocking several stress mechanisms that otherwise compromise cell structure and function 33941937

Engineering

biologically active recombinant protein from E. coli 33927995
permeability enhancement / liposomal / cationic? 33913042

Epigenomics

chromatin accessibility 34017130
Histone modifications histone modifications characteristic of active promoters, enhancers and gene bodies (H3K4me3, H3K27ac and H3K36me3) and inactive regions (H3K27me3) 33846645
Histone crotonylation / crotonyl-coenzyme A (CoA) 33450185
transcription memory / nascent/daughter epigenomic memory ; Hammer-seq (hairpin-assisted mapping of methylation of replicated DNA) 33686219
chromatin ubiquitylation 33664452
intracellular oxidative stress- skeletal muscle DNA methylome axis
chromatin stability dynamics
DNA demethylation / methylation
Epitranscriptomic mechanisms
Genome structural variation (SV) determinant quantitative trait/epitranscriptomic programming
Memory formation
progenitor network determinants
Nucleosome Remodeling
MicroRNAs (miRNAs) are small regulatory RNAs of relatively long half-life in non-proliferative human cells
genotypic locus susceptibility mapping
Chromatin remodelling via genomic DNA hydroxymethylation distribution (transcription memory) 33960278
adolescent stress dependent neuroimmune transcriptinomic modification (stress dependent epigenetic memory) 33558677
chromatin density; four major families of nucleosome remodeler complexes in mammals (SWI/SNF (switch/sucrose non-fermentable), ISWI (imitation switch), CHD (chromodomain helicase DNA binding) and INO80) are protein assemblies of a catalytic ATPase plus accessory subunits. 33558757

Metagenomics

RNA modification ( N6-methyladenosine (m6A)/ RNA m 6 A reader YTHDC1) dependent chromatin modification and retrotransposon repression 33658714
Phenotypic plasticity
Ex vivo chimerism 33861963
non-random (translational amino acid replacement genomic segment clustering) distribution 33953399
deep-time palaeogenomics 33597750

Microbiology

Host-microbiota compartment boundary nowcasting
Endotoxemic mechanisms
Gram negative bacterial phylogenetic host/phage dependent evolutionary divergence (CRISPR/Cas systems)/genetic variance determines host response severity/trajectory
Intra-host (pleomorphic) anaerobic bacteria quorum sensing (QS) networks
Latency reservoirs
Periodontal disease (p gingivalis) dependent coronary artery endothelial dysfunction 33677586
Prokaryotic/viral stage-specific quorum sensing / Autoinduction / density; Epigenetic (host histone methylation) response
type I interferon (IFN-1) response
Viral immune evasion evolution trajectories
Viral entry genetic variance (entry glycan/glycoprotein tropism) preferential viral entry tropism determines immunopathogenic disease severity trajectory
viral/bacterial mediated host immune response signature pathology predisposition / dysbiosis susceptibility 33883226
forward line quorum sensing; intra-/ inter-community parasites-host axis communication mechanisms extracellular vesicles (EVs) /heterogenous nanoparticles containing protein, lipid, nucleic acid, metabolites/(~30-5000 nm)/ biogenesis 33933651

Microbiome/Dysbiosis/Inflammation

microbiome-gut-brain axis sensory mechanisms 33953396

Organelle/Sub Structures

ECM

extracellular matrix viscoelasticity 33707778

Mitochondria

Low-grade mitochondrial stress; ergogenic mitohormesis
Caffeine induces cAMP/PKA/AMPK signaling dependent mitochondrial fission.
Central nervous system (CNS) specific Mitochondrial biogenesis/integrity 33415987
Mitochondria are an autonomous/spatially segregated parallel functioning genome within eukaryotic nuclear genomic.
Mitochondria organizational genome unit = nucleoid = mitochondrial DNA (mtDNA) + architectural proteins.
Mitochondrial respiration; ATP, respiration generates biosynthetic precursors (ie aspartate)/ essential substrates for nucleotide synthesis.
mitochondrial oxidative stress derivative clearance 33665835
Oxidative phosphorylation (OXPHOS) 33852893
Mitochondrial fission signatures toward autophagy or biogenesis 33953403

TGN

Nucleocytoplasmic transport (NCT) 34059832

Neoplasia

successive clonal population expansion via sequential acquisition of (? / somatic mutations) 33571445
Meiotic programs are potentially dangerous to genome stability and could be disastrous if activated in proliferative cells. 33658710

RNA

Transcriptinomics

single-cell RNA sequencing (scRNA-seq) 33721368

Noncoding ncRNA

Small nuclear ribonucleoprotein particle (snRNP)
Long non-coding RNAs (lncRNAs)
Small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs)
Circular RNAs (circRNAs)
First exons of enhancer-generated long noncoding RNAs (elncRNAs) elncRNAs / promoter-antisense long noncoding RNAs (pa-lncRNAs) pa-lncRNAs-dependent (cis-regulatory element) splice machinery activity /extragenic transcription modulation. 33767452
Humans genome lncRNA 30,000–60,000 long noncoding RNAs (lncRNAs) 33958760
miR-138 dependent viral latency 33558653

Phase Separation

chromosome/chromatin architecture; phase-separation dependent sub cellular/sub nuclear structures
Nanocluster Reorganization
phase separation dependent exonuclease endonuclease catalytic regulation outer shell at the droplet periphery selective environment
CaRriers of the Trans-Golgi network to the cell Surface (CARTS)
spatial distinction interactomes

Post transcription/translation

Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs 33497605
polyadenylation mechanics 33619322
targeted protein degradation technologies; Trim-Away https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733393/
targeted protein degradation technologies; Small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) induce the degradation of neo-substrates by hijacking E3 ubiquitin ligases 33567268
phosphorylation code dependent central signalling hub integration 33658715

Temporal Development

Central nervous system (CNS) neurodegeneration/organismal aging through peripheral tissues; skeletal muscle proteasome stress influences amylase/maltose-mediated adaptive response-dependent retinal and brain stress (aging). 33773104

Vesicular Traffic

exosome-derived miRNA sequencing to predict viral host seroconversion 33666247
Regenerative role of mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs) 33369392
Ribonucleoprotein complex-dependent extracellular RNA (exRNAs)/ncRNA/miRNA extracellular vesicle (EV) assembly units transmission from systemic circulation to Central Nervous System (CNS) via blood-brain barrier (BBB) traverse.
mesenchymal stem cell exosomal derivatives trafficking
Microfilament/Microtubule dependent endosomal trafficking mechanisms
Urinary extracellular vesicle (uEVs) traffic/excretion
extracellular vesicle monitoring of small-molecule chemical occupancy and protein expression (ExoSCOPE) 33686255