The authors say that R is the major source of cancer. They define R as the number of random mistakes that occurs during DNA replication and that R increases as we age. How does this model fit into cancer in infants and children?
The authors say that “exhaustively documented fact that about three mutations occur every time a normal cell divides and that normal stem cells often divide throughout life”, so does the collection of mutations per cell lead to more dramatized mutations per cell division (ie. an exponential increase in mutations per cell division rather than a linear increase of the consistent three mutation/ cell division)?