User:Yanan Du

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Yanan Du

Yanan Du Ph.D

Principle Investigator/Professor

Department of Biomedical Engineering, School of Medicine, Tsinghua University, China, 100084


Department website: BME@Tsinghua

Lab Website:


  • Postdoc, Harvard-MIT Science and Technology, MIT; Brigham & Woman's hospital, Harvard Medical School
  • PhD, Bioengineering, National University of Singapore
  • BEng, Chemical Engineering, Tsinghua University

Professional experiences

  • 2009.5-2010-8 Research affiliate, Wyss Institute for Biologically Inspired Engineering, Harvard University, USA
  • 2004.5-2007.7 Research affiliate, Institute of Bioengineering and Nanotechnology, A-STAR, Singapore

Research interests

  1. Cell/Tissue Engineering, Biomaterials;
  2. Nano/microscale technologies for bio-sensing, diagnostic and drug screening;
  3. Bio-mimetic in vitro physio/pathological model;

Professional activities

  • Editorial Board member of "Biomaterials and Biodevices",VBRI Press
  • Editorial Board member/Associate editor of "Journal of Medical Imaging and Health Informatics"
  • IEEE-Engineering in Medicine and Biology Society (IEEE-EMBS) Technical committee on “Bionanotechnology”.
  • Guest editor of Journal of Nanomaterials
  • Guest editor of Journal of Mechanics in Medicine and Biology
  • Reviewer for ‘Advanced Materials’;‘Integrative biology’; ‘Biomedical Devices’; ‘Biofabrication’; ‘Acta biomaterialia’; ‘Journal of Mechanics in Medicine and Biology’; ‘Biomicrofluidics’; ‘Composite Part B: Engineering’; ‘WIREs Nanomedicine & Nanobiotechnology’, ‘ Vascular cell’;‘Society For Biomaterials 2011 Annual Meeting’;
  • Member of the Biomedical Engineering Society since 2008



  1. Hui Chen, Xiaokang Li, Yanan Du, '1D~3D Nano-engineered Materials for Biomedical Application; Chapter 1 in‘"Integrated Biomaterials for Medical Applications"; Edited by Murugan Ramalingam and Ashutosh Tiwari; VBRI Press (2012) (Book Chapter).
  2. Xiaokang Li, Claudia wittkowske, Rui Yao, Yanan Du, 'Hydrogel as stem cell niche for in vivo applications in regenerative medicine'; Chapter 2 in “Biomaterials and Stem Cells in Regenerative Medicine” edited by Murugan Ramalingam, Seeram Ramakrishna and Serena Best; CRC Press (2012) (Book Chapter)

Before Tsinghua

Journal Articles

  1. Y. Du, M. Ghodousi, H. Qi, N. Haas, W. Xiao, A. Khademhosseini ‘Sequential assembly of cell-laden hydrogel constructs to engineer vascular-like microchannels’ Biotechnology and Bioengineering "in press" (2011)
  2. H. Qi, Y. Du, L. Wang, H. Bae, H. Kaji, Ali Khademhosseini ‘Patterning Single mouse embryonic bodies with defined polarities in 3D hybrid microgel’, Advanced materials (2011) 22(46):5276-81 (co-first author) (cover, reported by Technology review, Material review)
  3. Yanagawa F, Kaji H, Jang YH, Bae H, Y. Du, Fukuda J, H. Qi, A. Khademhosseini ‘Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs'. J Biomed Mater Res A . in press (2011)
  4. Xiao W, He J, Nichol JW, Wang L, Hutson CB, Wang B, Y. Du, Fan H, Khademhosseini A. ‘Synthesis and characterization of photocrosslinkable gelatin and silk fibroin interpenetrating polymer network hydrogels.’ Acta Biomater . in press (2011)
  5. J. He, Y. Du, Y. Guo, M. Hancock, B. Wang, H. Shin, J. Wu, D. Li, A. Khademhosseini ‘Microfluidic synthesis of composite cross-gradient materials for Investigating cell-biomaterial interactions’ Biotechnology and Bioengineering 2010 108:175-85 (co-first author)
  6. J. Wu, I. Wheeldon, Y. Guo, T. Lu, Y. Du, B. Wang, J. He, Y. Hu, A. Khademhosseini ‘Nanoliter-Scale Chamber array for High Throughput Screening of Drug Cytotoxicity and Drug-Drug Interactions, Biomaterials, 32:841-8 (2011)
  7. Y. Du, M. Hancock, J. He, J. Villa-Uribe, B. Wang, D. Cropek, A. Khademhosseini ‘Convection driven generation of long-range material gradients’ Biomaterials 31:2686-2694 (2010)
  8. Y. Du, M. Ghodoosi, E. Lo, M. Vidula, O. Emir, A. Khademhosseini ‘Surface-directed assembly of cell-laden microgels as 3D tissue constructs’ Biotechnology and Bioengineering 105(3): 655-662 (2010)
  9. J. He, Y. Du, J. Villa-Uribe, A. Khademhosseini ‘Rapid generation of hydrogel chemical/mechanical gradient in a simple microfluidic device for biological applications’ Advanced Functional Materials 20(1): 131-137 (2010) (co-first author)
  10. N. Kachouie, Y. Du, H. Bae, M. Khabiry, A.F. Ahari, B. Zamanian, J. Fukuda, A. Khademhosseini ‘Directed assembly of cell-laden hydrogels for engineering functional tissues’ Organogenesis in press
  11. Z. Shi, N. Chen, Y. Du, A. Khademhosseini, M. Alber ‘Stochastic model of self-assembly of cell-laden hydrogels’ Physical Review E 80: 061901 (2010)
  12. Y. Du, J. Shim, M. Vidula, Matthew J. Hancock, E. Lo, B. Chung, M. Khabiry, J. Borenstein, D. Cropek, A. Khademhosseini ‘Rapid generation of spatially and temporally controllable centimeter-length concentration gradients in a microfluidic device’ Lab on a Chip 9(6): 741-848 (2009) (cover)
  13. M. Khabiry, B. Chung, M. Hancock, H. Soundararajan, Y. Du, D. Cropek, A. Khademhosseini ‘Cell Docking within Double Grooved Substrates in a Microfluidic Device’ Small 5(10): 1186-1194 (2009)
  14. Y. Du, E. Lo, S. Ali, A. Khademhosseini, ‘Directed assembly of cell-laden microgels for fabrication of 3D tissue engineering constructs’ Proceedings of the National Academy of Sciences 105(28): 9522-7 (2008) (Reported by Nature, Technology Review, Focus, Scientific America and as spotlight at MIT website homepage)
  15. Y. Du, E. Lo, M. Vidula, M. Khabiry, A. Khademhosseini “Method of Bottom-up Directed Assembly of Cell-Laden Microgels’ Cellular and Molecular Bioengineering (2008) 1: 157-162 (Outstanding paper award in Biomedical Engineering Society 2008)
  16. Y. Du, R. Han, S. Ng, F. Wen, T. Wohland, H. Yu ‘A Novel Synthetic Sandwich Culture of 3D Hepatocyte Monolayer’ Biomaterials 29: 290-301 (2008)
  17. Y. Toh, J. Zhang, Y. Khong, Y. Du, W. Sun, H. Yu ‘Capillary electrophoresis with laser induced fluorescence detection (CE-LIF) as a common analytical platform for sensitive quantification of hepatic metabolic functions’ Analyst 133(3): 326-30 (2008)
  18. Y. Du, R. Han, S. Ng, J. Ni, W. Sun, T. Wohland, S. Ong, H. Yu ‘Identification and characterization of a novel pre-spheroid 3D hepatocyte monolayer on galactosylated substratum’ Tissue Engineering 13(7): 1455-1468 (2007)
  19. X. Pan, C. Aw, Y. Du, H. Yu, T. Wohland ‘Characterization of poly(acrylic acid) diffusion dynamics on the grafted surface of poly(ethylene terephthalate) films by fluorescence correlation spectroscopy’ Biophysical Reviews and Letters 1 (4): 1-9 (2006)
  20. Y. Du, S. Chia, R. Han, S. Chang, H. Yu, "3D hepatocyte monolayer on hybrid RGD/galactose substratum” Biomaterials 27: 5669-5680 (2006)

Book chapters

  1. Ali Khademhosseini, Yanan Du, Bimal Rajalingam, Joseph P. Vacanti, Robert Langer, ‘Microscale Technologies for Tissue Engineering’; In “Advanced in tissue engineering ”; Edited by Julia Polak, Sakis Mantalaris and Sian E Harding; Imperial College Press (2008), P349-369, (co-first author)
  2. Yanan Du, Donald Cropek, Mohammad R. Kaazempur Mofrad, Eli J. Weinberg, Ali Khademhosseini, Jeffrey Borenstein, ‘Microfluidic systems for engineering vascularized tissue constructs’; In “Microfluidics for Biological Applications”; Edited by Wei-Cheng Tian and Erin Finehout; Springer (2009)
  3. Pilnam Kim, Yanan Du, Ali Khademhosseini, Robert Langer, Kahp Y. Suh, ‘Unconventional patterning methods for BioNEMS’; In “Nanopatterning and Applications”; Edited by John A. Rogers and Hong H. Lee; Wiley (2009) (co-first author)
  5. Adam Hacking, Yanan Du, Ali Khademhosseini, ‘Polymer patterning for biological application’; In “Comprehensive Polymer Science, 2nd edition”; Edited by Martin Moeller and Krzysztof Matyjaszewski; Elsevier (expected 2011)


  1. Yanan Du, Rongbin Han, Hanry Yu ‘Stabilizing a novel 3D hepatocyte monolayer culture by a hybrid bioactive substratum for hepatocyte-based applications’ PCT/SG2007/000147 (2008), EP Application No./Patent No.: 07748592.6 – 1222 (2009)
  2. Ali Khademhosseini, Yanan Du, ‘Method and system for generating spatially and temporally controllable concentration gradients’ PCT/US2009/064555 (2009)
  3. Ali Khademhosseini, Jeffrey Borenstein, Hojae Bae, Yanan Du, Jane Wang, Jason Nichol, Robert Langer, ‘Microfluidic construction of vascularized tissues’, Invention disclosure submitted (2010)
  4. Ali Khademhosseini, Masoud Khabiry, Bong Geun Chung, Matthew Hancock, and Yanan Du, ‘Double-groove cell docking’ Invention disclosure submitted (BWH, NP-043214-066771) (2010)

Useful links