User:Xiaosai Yao

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Graduate Student
Wittrup Lab
Department of Biological Engineering
Massachusetts Institute of Technology

Office: E19-563


  • 2008 - current, PhD, MIT
  • 2007, BS, Johns Hopkins

Research interests

I am interested in developing cancer therapeutics using protein engineering, in particular affinity maturation with yeast surface display developed by the Wittrup lab. I design and synthesize tumor-targeting antibodies. I am also interested in the mechanisms of cancer metastasis. My research involves the characterization of circulating tumor cells.

Previous research experience

  • Institute of Bioengineering and Nanotechnology Singapore, 2007-2008

Advisor: Dr. Andrew Wan
Encapsulation of pancreatic islets with polyelectrolyte fibers for immunoisolation

  • The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, 2005-2007

Advisor: Dr. Elizabeth Jaffee
Characterization of Foxp3+ CD8+ tumor infiltrating lymphocytes in FVB and neu-N transgenic mouse models

  • Weatherall Institute of Molecular Medicine Oxford University, 2006

Advisor: Dr. Vincenzo Cerundolo
Study of CD1e and gamma-delta TCR

  • Institute of Molecular Cell Biology Singapore, 2004-2006

Advisor: Prof. Wanjin Hong
Characterization of SIMPLE (Small Integral Membrane Protein of Lysosome/Late Endosome)