User:Wayne G. Shreffler

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Contact Info

Wayne G. Shreffler

Wayne G. Shreffler, MD, PhD

MassGeneral Hospital for Children &

MGH, Center for Immunology and Inflammatory Diseases

Bldg. 149-13th St. Rm. 8312

Charlestown MA 02129



  • 1998, MD, New York University
  • 1997, PhD, New York University
  • 1996, MS, New York University
  • 1991, BS, University of Washington

Research interests

  1. Mechanisms of Allergenicity
  2. Immune Tolerance and Food Allergy
  3. Mechanisms of Immediate Hypersensitivity and its Regulation


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PubMed Link

Selected Research Articles

  1. Wanich N, Nowak-Wegrzyn A, Sampson HA, and Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr;123(4):789-94.e20. DOI:10.1016/j.jaci.2008.12.1128 | PubMed ID:19348919 | HubMed [Paper1]
  2. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, and Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan;123(1):43-52.e7. DOI:10.1016/j.jaci.2008.09.051 | PubMed ID:19130927 | HubMed [Paper2]
  3. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, and Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar;121(3):737-743.e10. DOI:10.1016/j.jaci.2007.11.039 | PubMed ID:18234310 | HubMed [Paper3]
  4. Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, and Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15;177(6):3677-85. DOI:10.4049/jimmunol.177.6.3677 | PubMed ID:16951327 | HubMed [Paper4]
  5. Shreffler WG, Lencer DA, Bardina L, and Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct;116(4):893-9. DOI:10.1016/j.jaci.2005.06.033 | PubMed ID:16210066 | HubMed [Paper5]
  6. Shreffler WG, Beyer K, Chu TH, Burks AW, and Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr;113(4):776-82. DOI:10.1016/j.jaci.2003.12.588 | PubMed ID:15100687 | HubMed [Paper6]

All Medline abstracts: PubMed | HubMed

Selected Review Articles

  1. Lin J, Bardina L, and Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009;524:259-72. DOI:10.1007/978-1-59745-450-6_19 | PubMed ID:19377951 | HubMed [Paper1]
  2. Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb;123(2):352-3. DOI:10.1016/j.jaci.2008.12.1119 | PubMed ID:19203659 | HubMed [Paper2]
  3. Moloney M and Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov;101(5):544-9. DOI:10.1016/S1081-1206(10)60295-5 | PubMed ID:19055210 | HubMed [Paper3]
  4. Berin MC and Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun;121(6):1311-20; quiz 1321-2. DOI:10.1016/j.jaci.2008.04.023 | PubMed ID:18539190 | HubMed [Paper4]
  5. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun;6(3):226-33. DOI:10.1097/01.all.0000225165.83144.2f | PubMed ID:16670519 | HubMed [Paper5]

All Medline abstracts: PubMed | HubMed

Useful links