- Define your research proposal by making a wiki page to collect your ideas and resources. Keep in mind that your presentation to the class will need:
- a brief project overview
- sufficient background information for everyone to understand your proposal
- a statement of the research problem and goals
- project details and methods
- predicted outcomes if everything goes according to plan and if nothing does
- needed resources to complete the work
You can organize your wiki page along these lines or however you feel is most helpful. Print your user page for next time, making sure it defines your topic, your idea and some references you've collected and summarized.
source: Folding DNA to create nanoscale shapes and patterns Rothemund, Paul. vol 440, 16 march 2006|doi:10.1038/nature04586
summary: bottom-up fabrication, the commonly used nanostructuring method, exploits the intrinsic properties of atoms and molecues. Top-down method is much better. This method can be developed from investigating self-assembly of DNA molecules. A pattern can be achieved by using short single strands of DNA to direct the folding of a long, single strand of DNA into desired shapes. However, there are problems present such as 1) sequences must be optimized to avoid 2nd structure or undesired binding interations, 2) strands have to be highly purified, and 3) strand concentrations must be at the same molars. The successful factors required are 1) strand invasion, 2) an excess of staples, 3) cooperative effects and 4) design that intentionally does not rely on binding between staples. Method described in the paper is easy to implementm, high yield and inexpensive. It can also be applied to create more complex structures by combining with other methods, like hierarchical and algorithmic self-assembly, or top-down fabrication techniques. Once combined successfully, the process can be used to create nanowires and nanoparticles. It'd also allow bio experiments aimed at modelling complex protein assemblies.
project step-by-step: 1) find out the difference of all the methods described in the paper(self-assembly, top-down, bottom-up) 2) try solving the problems 3) find out more applications of this method
applications: nano breadboard nano wire