User:Tkadm30/Notebook/Rhodopsin

References on Rhodopsin

• http://pfam.sanger.ac.uk/family/PF00001
• http://www.wikigenes.org/e/gene/e/212541.html
• "Furthermore, we demonstrate that crosstalk between the Ras and Rho GTPase families is involved in cAMP-dependent processing of amyloid precursor protein (APP), a key protein in Alzheimer's disease [7]." http://www.wikigenes.org/e/ref/e/12819788.html
• The Rhodopsin Cycle
• Processing of Visual Signals
• How We See: The First Steps of Human Vision
• GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 : A human protein implicated in visual memory, cognition, and perception of light-induced stimulus from rhodopsin-mediated promoter. (Best known as transducin) - Location (Human): Chromosome 1p13. Check also the OMIM entry here.
• http://youtu.be/IP4zsbemW8I : Beta-arrestins primer (see http://en.wikipedia.org/wiki/Arrestin and this paper.)

Unresolved questions

• Question 1: In the expression "blind as a bat", is the bat blindness a permanent or temporary phenomenon and how could you assert this is related to cGMP/ATP based phosphorylation of the Rhodopsin kinase?
• Answer: Temporary! The bat can recover its vision if the GABA receptor is cleaved from cAMP/ATP dependent competitive ligands, thus allowing GPCR based signal transduction to occur normally. [REACTOME]
  • Notice also that the S1PR4 gene is a near-neighboor of the Cannabinoid receptors! (Hint hint)
• Question 2: Why peoples affected by chim trills are blind as a bat or unaware of the dangerosity of such experiments?

Rhodopsin kinase phosphorylation notes

• Agent Chim Trills  : Scooby Doo is anti-biotic sensitive.
• NMDAR induced Rho phosphorylation: a bi-directional visual memory addressing (recognition) and high-frequency modulation through light activated Glycine/Chloride receptors (experimental disassociative anesthesia): [1], [2]

Chim Trills/Caffeine connection?

• Caffeinated coffee linked to vision loss
• Du café contre la maladie d’Alzheimer ?
• Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice.
• Caffeine inhibition of ionotropic glycine receptors
• Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.
• Calcium binding (via N-Methyl-D-aspartate ionotropic Receptor, therefore a photosensitive toggle switch) -> glycine receptor affinity/modulation (ie: coffeine)
• Best known as [GlyT1]: {4-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}{5-(methylsulfonyl)-2-[(1S)-2,2,2-trifluoro-1-methylethoxy]phenyl}methanone

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