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Microglial activation in the PFC

  • Activation of the microglia by aluminium oxide disrupt the cytokine/neurotrophin balance.
  • Possible role of microglia-derived BDNF signaling on intracellular Ca2+ elevation? [1]

Nanotoxicity of fine particulate matter (PM2.5)

  • Fly-ash particulate matter includes:
    • aluminium oxide
    • silicon dioxide
    • titanium dioxide
    • barium oxide
    • iron oxide
    • cadmium
    • arsenic
    • dimethyl sulfate and monomethyl sulfate[2]
  • Exposure to coal fly ash is nanotoxic and may cause neuroinflammation via oxidative stress production. [3]
  • Coal fly ash is a source of particulate matter.
  • Fine particulate matter (PM2.5) exposure may induce chronic COPD pathogenesis.[4]



Phenomenology of consciousness

The brain is not the source of consciousness:

Intrinsic awareness (IA):

Ubiquity of consciousness:

Political manipulations of psychiatry

Sluggish schizophrenia

Retrograde signaling

Glycinergic neurotransmission trafficking

Allosteric modulation of glycine receptors by endocannabinoids

  • THC and anandamide may modulates synaptogenesis in the retina and brain through glycinergic transmission [5]
  • Intracellular DHA delivery facilitate glutamatergic NMDA receptor function in the presence of glycine [6]
  • THC and anandamide enhance NMDA-dependent LTP through glycine receptor activation

CB1-induced cholinergic neurotransmission

  • Hypothalamic POMC neurons promote CB1-induced feeding [7]
  • Adenosine antagonist (caffeine) potentiate corticostriatal neurotransmission (connectivity) through presynaptic CB1 receptor activation. [8]
  • Monoamine oxidase inhibition affects cannabinoid-induced synaptogenesis. [9]

Intracellular CB1/BDNF signaling

  • CB1 receptor activation may induce corticostriatal neuroprotection through a PI3K/Akt/mTORC1/BDNF pathway. [10]

Pineal gland

  • Dopamine receptors in the pineal gland may control melatonin production via anandamide trafficking? [11][12]

Social neuroscience of cannabis smoking

Synaptic hypercomputation

Biological utilization of quantum non-locality in microtubules:

Biophotonic non-locality of tubulin heterodimer:

  • The non-local (quantum) nature of biophotonic energy may require ultra-fast optical communication channels in MTs to potentiate a presynaptic action potential into a visible waveform! (Reference needed)
  • Is the tubulin dipole moment phase-dependent? (Reference needed)

Phase coherence of synaptic hypercomputation

Retrograde signaling and synaptogenesis:


  1. [Paper11]

    Positive feedback loop of autocrine BDNF from microglia causes prolonged microglia activation.

  2. [Paper8]

    Dimethyl and monomethyl sulfate: presence in coal fly ash and airborne particulate matter.

  3. [Paper9]

    Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure.

  4. [Paper10]

    Fine particulate matter in acute exacerbation of COPD.

  5. [Paper2]

    Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.

  6. [Paper3]

    Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex.

  7. [Paper4]

    Hypothalamic POMC neurons promote cannabinoid-induced feeding.

  8. [Paper5]

    Caffeine drinking potentiates cannabinoid transmission in the striatum: interaction with stress effects.

  9. [Paper6]

    Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice.

  10. [Paper7]

    The CB₁ cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway.

  11. [Paper25]

    The rat pineal gland comprises an endocannabinoid system.

  12. [Paper26]

    Rhythmic control of endocannabinoids in the rat pineal gland.

  13. [Paper1]

    Nasal instillation of nanoparticle-rich diesel exhaust particles slightly affects emotional behavior and learning capability in rats

  14. [Paper12]

    Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation.

  15. [Paper13]

    Amnesia and Crime.

  16. [Paper14]

    Splendor in the Grass? A Pilot Study Assessing the Impact of Medical Marijuana on Executive Function

  17. [Paper15]

    Possible existence of optical communication channels in the brain

  18. [Paper16]

    Endocannabinoid signaling mediates oxytocin-driven social reward

  19. [Paper17]

    Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats.

  20. [Paper18]

    Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review.

  21. [Paper19]

    Vitamin D deficiency and essential hypertension.

  22. [Paper20]

    Vitamin D as an effective treatment approach for drug abuse and addiction.

  23. [Paper21]

    The in vitro GcMAF effects on endocannabinoid system transcriptionomics, receptor formation, and cell activity of autism-derived macrophages.

  24. [Paper22]

    Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance.

  25. [Paper23]

    Psychosis and the Control of Lucid Dreaming.

  26. [Paper24]

    Cannabis in the Treatment of Dystonia, Dyskinesias, and Tics.

  27. [Paper27]

    Melatonin as a potential antihypertensive treatment.

  28. [Paper28]

    Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects.

  29. [Paper29]

    Multiple Mechanistically Distinct Modes of Endocannabinoid Mobilization at Central Amygdala Glutamatergic Synapses.

  30. [Paper30]

    The endocannabinoid system modulating levels of consciousness, emotions and likely dream contents.

  31. [Paper31]

    Insights into plant consciousness from neuroscience, physics and mathematics: A role for quasicrystals?

  32. [Paper31]

    Dreams and neuroholography: An interdisciplinary. Interpretation of development of homeotherm state in evolution

See also