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A jolie passage

  • Calcium chloride (CaCl2) != potassium chloride [Ca2+]
  • potassium chloride = food additive
  • potassium chloride = KCl (anhydrous) [Cl-]
  • KCl (-) mediated CREB1 gene expression: ($35.95)
  • Keywords: CREB1, NMDA, potassium chloride, CaM kinase, striatal neurons, dizocilpine (Ketamine), Serine (phosphorylation), orthogonal phenolic methylamide enolates, active methylenes enolates, metal-bound complexes, -rC=NOH, carbenes (NHC), 4-methylimidazole derivatives (4-Mel, 4-methoxy (4-met), N-benzyl methylamine, pyridineN-methyl acylamino pyridine), Ethanolamine
  • See also: NMDA dependent cell adhesion (aka the Wnt (Calcium Binding) pathway), Shikimate pathway

4-methylamino carboxilic protection: Fast and versatile conversion of C-(2-phenyl-cyclohexyl) methylamide esters in presence of a nucleophilic Schiff base (reduktiv)

  1. PMB
  2. 4-Dialkylaminopyridines as Highly Active Acylation Catalysts. (New synthetic method)
  3. Significant papers (Topic: microwave induced methylphenidate HCl synthesis)
    1. C-(2-Phenyl-Cyclohexyl)-Methylamine Compounds for the Treatment of Anxiety Disorders
  4. Keywords: tau protein hyperphosphorylation, Alzheimer Disease, MK-801

Orthogonal serine/threonine-specific GSK3 inhibitors


  • Désactivation sélective du récepteur NMDAR1 (Ser133?)
    • Note: Ser133 ? (NMDAR1): un récepteur critique à la formation de la protéine beta-amyloid (APP) 4 d'après de récentes études à ce sujet. [2]


  1. Macías W, Carlson R, Rajadhyaksha A, Barczak A, and Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 2;890(2):222-32. DOI:10.1016/s0006-8993(00)03163-2 | PubMed ID:11164788 | HubMed [CREB-2001]
  2. [Li-Hanahan-1-2013]
  3. De Cesare D, Jacquot S, Hanauer A, and Sassone-Corsi P. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12202-7. DOI:10.1073/pnas.95.21.12202 | PubMed ID:9770464 | HubMed [CREB-1998]
  4. Du K and Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem. 1998 Dec 4;273(49):32377-9. DOI:10.1074/jbc.273.49.32377 | PubMed ID:9829964 | HubMed [CREB-1998]
  5. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means AR, and McKnight GS. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol. 1994 Sep;14(9):6107-16. DOI:10.1128/mcb.14.9.6107 | PubMed ID:8065343 | HubMed [CREB-1994]
  6. Lee HJ, Mignacca RC, and Sakamoto KM. Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. J Biol Chem. 1995 Jul 7;270(27):15979-83. DOI:10.1074/jbc.270.27.15979 | PubMed ID:7608156 | HubMed [CREB-1995]

All Medline abstracts: PubMed | HubMed

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“Whenever the will to power falls off in any way, there will also be physiological decline, decadence. And when the most masculine virtues and drives have been chopped off the god of decadence, he will necessarily turn into a god of the physiologically retrograde, the weak.” – Friedrich Nietzsche - Link