User:Sunny Sharma

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Contact Info

Education

  • Research Fellow at MGH Cancer Center– Harvard Medical School
  • Research Associate at Institute of Molecular Biosciences, Goethe University, Frankfurt am Main, Germany [1]
  • 2014, PhD (Biology), Goethe University, Frankfurt am Main, Germany [2]
  • 2007, MS (Molecular Biology & Biochemistry), Guru Nanak Dev University, Amritsar, India [3]
  • 2005, BS, Bangalore University, Bangalore, India [4]

Awards

TFMD (Tosteon and Fund for Medical Discovery) Fellowship. (2018) [5]

EMBO (European Molecular Biology Organisation) Long Term Fellowship. (2014-2016)[6]

DAAD (Deutsche Akademische Austauschdienst) PhD scholarship (2010 - 2014) [7]

CEF (Excellence Cluster-Frankfurt am Main) PhD fellowship (2009 - 2010) [8]

ICMR (Indian Council of Medical Research) Junior Research Fellowship (2009 - 2010) [9]

Research interests

  1. Ribosome Biogenesis
  2. RNA modifications
  3. Developmental Biology
  4. Immunology
  5. Gerontology

Publications

18) A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes. [10]


17) Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping.[11]


16) Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation.[12]


15) Mapping of Complete Set of Ribose and Base Modifications of Yeast rRNA by RP-HPLC and Mung Bean Nuclease Assay.[13]


14) Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function.[14]


13) Ribosome biogenesis factor Tsr3 is the aminocarboxypropyl transferase responsible for 18S rRNA hypermodification in yeast and humans. [15]


12)‘View From A Bridge’: A New Perspective on Eukaryotic rRNA Base Modification.[16]


11) The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent.[17]


10) Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1.[18]


9) Identification of a new ribose methylation in the 18S rRNA of S. cerevisiae.[19]


8) Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.[20]


7) Absolute and relative quantification of RNA modifications via biosynthetic isotopomers.[21]


6) Partial methylation at Am100 in 18S rRNA of baker´s yeast shows ribosome heterogeneity on the level of eukaryotic rRNA modification. Plos One [22]


5) Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae.[23]


4) Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively.[24]


3) Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae.[25]


2) Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.[26]


1) Association of P2X7 receptor +1513 (A-->C) polymorphism with tuberculosis in a Punjabi population.[27]

Conferences/ Workshops

  1. Plenary talk at 10th Ribosome Synthesis meeting 19th-25th August, Brussels.[28]
  2. Seminar at RNA club, 16th October 2013 [29]
  3. Plenary talk at Yeast Meeting, Frankfurt 2013 [30]
  4. Poster presentation at 18th Annual RNA meeting of the RNA society, Davos, Switzerland [31]
  5. Seminar at RNA club, 26th September 2012 [32]
  6. Poster presentation at 9th International Conference on Ribosome Synthesis, Banff, Canada [33]

Useful links