User:Sebastian Muller Dunelm

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Contact Information

Sebastian Müller

Currently, I work in the G. Almouzni Lab at the Institut Curie as a postdoctoral researcher in epigenetics and chromatin dynamics.

Education

Research Interests

Centromeric Deposition Network of CenH3/CENP-A
Telomeric G-quadruplex
Shelterin and G-quadruplex formation
  • Exploring Chromatin Dynamics with Small Molecules
  • Cancer research: molecular and cellular mechanisms of the aetiology of cancer
  • DNA structure and function
  • G-quadruplex DNA and RNA
  • Synthesis of nucleic acid interacting small molecules
  • Epigenetic roles of DNA and RNA structures
  • Centromeres and satellite DNA

Skills

  • Languages: German (fluent), English (fluent), French (fluent)
  • Cell & Molecular Biology: Cell culture, Immunohistochemistry, fluorescence microscopy, fluorescent and luminescent cell assays (apoptosis, senescence, viability, cytotoxicity etc.), transfections, cloning, q-PCR, colony PCR, agarose and PA gel electrophoresis, DNA extraction, radioactive labelling, immunoprecipitation & pull down
  • Chemical Synthesis: Synthesis of small synthetic molecules, NMR, UV-vis, HRMS
  • Biophysics: FRET-melting, circular dichroism, nucleic acid NMR, fluorescent titration
  • I.T.: LaTeX, HTML, OriginLab, ChemDraw, Microsoft Office, Photoshop
  • Teaching: A-level teaching, teaching of undergrad students in supervisions and tutorials up to Masters level, supervision of 1st year Ph.D. students

Awards

  • 2011-current: Marie Curie Actions Postdoctoral Fellowship on the Nucleosome 4D network
  • 2006-2010: Cancer research UK, Scholarship, Cambridge, U.K.
  • 2005: Full Colours in Rowing, Durham University, College of St. Hild & St. Bede, U.K.
  • 2001: Buchpreis der Deutschen Physikalischen Gesellschaft, Germany

Personal Interests

  • Rowing
  • Classical Music
  • Gym and running
  • Piano
  • Ancient and modern history and archeology
  • Astronomy

Publications

[1] S. Müller, G. Almouzni, Biochim. Biophys. Acta., 2014, 1839, 241-50 “A network of players in H3 histone variant deposition and maintenance at centromeres”

[2] S. Müller, D. Sanders, R. Rodriguez, M. Di Antonio, S. Matsis and S. Balasubramanian, Org Biomol. Chem., 2012, 10, 6537-6546 “Small molecules that show selective growth inhibition for cancer cells, low cytotoxicity and induce telomere shortening”

[3] M. Bejugam, M. Gunaratman, S. Müller, S. Sewitz, D. A. Sanders, S. Neidle and S. Balasubramanian, ACS Med. Chem. Lett., 2010, 1, 306-310, “Targeting the c-Kit promoter quadruplexes with 6-substituted indenoisoquinolines”

[4] S. Müller, S. Kumari, R. Rodriguez and S. Balasubramanian, Nature Chem., 2010, 2, 1095-1098, “Small molecule-mediated G-Quadruplex isolation from human cells”

[5] S. Müller, G. D. Pantos, R. Rodriguez and S. Balasubramanian, Chem.Commun., 2009, 80-82, “Controlled-folding of a small molecule modulates DNA G-quadruplex recognition”

[6] R. Rodriguez, S. Müller, J. A. Yeoman, C. Trentesaux, J.-F. Riou and S. Balasubramanian, J. Am. Chem. Soc., 2008, 130, 15758-15759, “A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres”

[7] J. Jaiswal, G. Marlow, G. Summerill, I. Mahjneh, S. Müller, M. Hill, K. Miyake, H. Haase, L. Anderson, I. Richard, S. Kiuru-Enari, P. McNeil, S. Simon and R. Bashir, Traffic, 2006, 8, 77-88, “Patients with a non-dysferlin Myoshi Myopathy have a novel membrane repair defect”

[8] J. Jaiswal, K. Miyake, G. Summerill, S. Müller, I. Mahjneh, F. Baas, M. de Visser, P. McNeil and R. Bashir, Neuromuscular Disorders, 2005, 15, 692, “Defective membrane repair in non-dysferlin Miyoshi Myopathy”

Groups

G. Almouzni Research Group

S. Balasubramanian Research Group

R. Bashir Research Group