User:Ryan Walsh

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Contact Info

Ryan Walsh (an artistic interpretation)

I work in the DeRosa lab at Carleton University.


  • Currently enrolled, PhD Chemistry, Carleton University, Ottawa ON
  • 2006, MSc Anatomy and Neurobiology, Dalhousie University, Halifax NS
  • 1998, BSc Biochemistry, Dalhousie University, Halifax NS

Research interests

  1. Enzymes
  2. Aptamers
  3. DNA Origami


  1. Walsh R, Martin E, Darvesh S.Limitations of conventional inhibitor classifications. Integr Biol (Camb)., 2011, 3, 1197-1201 pmid=22038120
  2. Walsh R, Rockwood K, Martin E, Darvesh S. Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram. Biochim Biophys Acta. 2011 Aug 19;1810(12):1230-1235. pmid=21872646
  3. Shevchenko Y, Francis TJ, Blair DA, Walsh R, DeRosa MC, Albert J. In situ biosensing with a surface plasmon resonance fiber grating aptasensor. Anal Chem. 2011 Sep 15;83(18):7027-34. pmid=21815621
  4. Holahan MR, Madularu D, McConnell EM, Walsh R, DeRosa MC. Intra-accumbens injection of a dopamine aptamer abates MK-801-induced cognitive dysfunction in a model of schizophrenia. PLoS One. 2011;6(7):e22239. pmid=21779401
  5. Rockwood K, Walsh R, Martin E, Darvesh S. Potentially procholinergic effects of medications commonly used in older adults. Am J Geriatr Pharmacother. 2011 Feb;9(1):80-7. pmid=21459311
  6. Darvesh S, Pottie IR, Darvesh KV, McDonald RS, Walsh R, Conrad S, Penwell A, Mataija D, Martin E. Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-44. pmid=20181484
  7. DeRosa MC, Monreal C, Schnitzer M, Walsh R, Sultan Y. Nanotechnology in fertilizers. Nat Nanotechnol. 2010 Feb;5(2):91. pmid=20130583
  8. Walsh R, Martin E, Darvesh S. A method to describe enzyme-catalyzed reactions by combining steady state and time course enzyme kinetic parameters. Biochim Biophys Acta. 2010 Jan;1800(1):1-5. pmid=19840832
  9. Walsh R, DeRosa MC. Retention of function in the DNA homolog of the RNA dopamine aptamer. Biochem Biophys Res Commun. 2009 Oct 30;388(4):732-5. pmid=19699181
  10. Sultan Y, Walsh R, Monreal C, DeRosa MC. Preparation of functional aptamer films using layer-by-layer self-assembly. Biomacromolecules. 2009 May 11;10(5):1149-54. pmid=19385646
  11. Darvesh S, Darvesh KV, McDonald RS, Mataija D, Walsh R, Mothana S, Lockridge O, Martin E. Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. J Med Chem. 2008 Jul 24;51(14):4200-12. pmid=18570368
  12. Darvesh S, McDonald RS, Darvesh KV, Mataija D, Conrad S, Gomez G, Walsh R, Martin E. Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine. Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. pmid=17681768
  13. Walsh R, Martin E, Darvesh S. A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase. Biochim Biophys Acta. 2007 May;1770(5):733-46. pmid=17307293
  14. Darvesh S, Walsh R, Martin E. Homocysteine thiolactone and human cholinesterases. Cell Mol Neurobiol. 2007 Feb;27(1):33-48. pmid=16955366
  15. Darvesh S, McDonald RS, Darvesh KV, Mataija D, Mothana S, Cook H, Carneiro KM, Richard N, Walsh R, Martin E. On the active site for hydrolysis of aryl amides and choline esters by human cholinesterases. Bioorg Med Chem. 2006 Jul 1;14(13):4586-99. pmid=16504521
  16. Darvesh S, McDonald RS, Penwell A, Conrad S, Darvesh KV, Mataija D, Gomez G, Caines A, Walsh R, Martin E. Structure-activity relationships for inhibition of human cholinesterases by alkyl amide phenothiazine derivatives. Bioorg Med Chem. 2005 Jan 3;13(1):211-22. pmid=15582466
  17. Darvesh S, Martin E, Walsh R, Rockwood K. Differential effects of lipid-lowering agents on human cholinesterases. Clin Biochem. 2004 Jan;37(1):42-9. pmid=14675561
  18. Darvesh S, Walsh R, Kumar R, Caines A, Roberts S, Magee D, Rockwood K, Martin E Inhibition of human cholinesterases by drugs used to treat Alzheimer disease. Alzheimer Dis Assoc Disord. 2003 Apr-Jun;17(2):117-26. pmid=12794390
  19. Darvesh S, Walsh R, Martin E. Enantiomer effects of huperzine A on the aryl acylamidase activity of human cholinesterases. Cell Mol Neurobiol. 2003 Feb;23(1):93-100. pmid=12701885
  20. Darvesh S, Kumar R, Roberts S, Walsh R, Martin E. Butyrylcholinesterase-Mediated enhancement of the enzymatic activity of trypsin. Cell Mol Neurobiol. 2001 Jun;21(3):285-96. pmid=11569538

Invited Book Chapter

  1. Walsh R. Alternative Perspectives of Enzyme Kinetic Modeling In Medicinal Chemistry and Drug Design Ed. Ekinci D, InTech 2012. isbn=978-953-51-0513-8

Useful links