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Contact Info

Roger L. Chang
  • Roger L. Chang
  • Postdoc, lab of Pamela Silver
  • Systems Biology Dept, Harvard Medical School
  • 200 Longwood Avenue WAB 561
  • Boston, MA 02115
  • Email me through OpenWetWare


  • 2012, PhD in Bioinformatics and Systems Biology, University of California San Diego (lab of Bernhard Ø. Palsson)
  • 2005, BA in Molecular and Cell Biology, University of California Berkeley (lab of Nipam Patel)

Research interests

  1. Synthetic RNA Structure Engineering
  2. Radioresistance of Deinococcus radiodurans
  3. Metabolic Systems Modeling
  4. Structural Systems Biology


  1. Chang RL, Xie L, Bourne PE, and Palsson BO. Antibacterial mechanisms identified through structural systems pharmacology. BMC Syst Biol. 2013 Oct 10;7:102. DOI:10.1186/1752-0509-7-102 | PubMed ID:24112686 | HubMed [BMC_Syst_Biol_2013_Oct_10_7-102_Antibacterial_mechanisms_identified_through_structural_systems_pharmacology]
  2. O'Brien EJ, Lerman JA, Chang RL, Hyduke DR, and Palsson BØ. Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction. Mol Syst Biol. 2013 Oct 1;9:693. DOI:10.1038/msb.2013.52 | PubMed ID:24084808 | HubMed [Mol_Syst_Biol_2013_Oct_1_9_693_Genome-scale_models_of_metabolism_and_gene_expression_extend_and_refine_growth_phenotype_prediction]
  3. Chang RL, Andrews K, Kim D, Li Z, Godzik A, and Palsson BO. Structural systems biology evaluation of metabolic thermotolerance in Escherichia coli. Science. 2013 Jun 7;340(6137):1220-3. DOI:10.1126/science.1234012 | PubMed ID:23744946 | HubMed [Science_2013_Jun_7_340_1220_1223_Structural_systems_biology_evaluation_of_metabolic_thermotolerance_in_Escherichia_coli]
  4. Nam H, Lewis NE, Lerman JA, Lee DH, Chang RL, Kim D, and Palsson BO. Network context and selection in the evolution to enzyme specificity. Science. 2012 Aug 31;337(6098):1101-4. DOI:10.1126/science.1216861 | PubMed ID:22936779 | HubMed [Science_2012_Aug_31_337_1101_1104_Network_context_and_selection_in_the_evolution_to_enzyme_specificity]
  5. Chang RL, Ghamsari L, Manichaikul A, Hom EF, Balaji S, Fu W, Shen Y, Hao T, Palsson BØ, Salehi-Ashtiani K, and Papin JA. Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism. Mol Syst Biol. 2011 Aug 2;7:518. DOI:10.1038/msb.2011.52 | PubMed ID:21811229 | HubMed [Mol_Syst_Biol_2011_Aug_2_7518_Metabolic_network_reconstruction_of_Chlamydomonas_offers_insight_into_light-driven_algal_metabolism]
  6. Chang RL, Xie L, Xie L, Bourne PE, and Palsson BØ. Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Comput Biol. 2010 Sep 23;6(9):e1000938. DOI:10.1371/journal.pcbi.1000938 | PubMed ID:20957118 | HubMed [PLoS_Comput_Biol_2010_Sep_23_6_e1000938_Drug_off-target_effects_predicted_using_structural_analysis_in_the_context_of_a_metabolic_network_model]
  7. Chang RL, Luo F, Johnson S, and Scheuermann RH. Deterministic graph-theoretic algorithm for detecting modules in biological interaction networks. Int J Bioinform Res Appl. 2010;6(2):101-19. DOI:10.1504/IJBRA.2010.032115 | PubMed ID:20223734 | HubMed [Int_J_Bioinform_Res_Appl_2010_6_101_19_Deterministic_graph-theoretic_algorithm_for_detecting_modules_in_biological_interaction_networks]
  8. Manichaikul A, Ghamsari L, Hom EF, Lin C, Murray RR, Chang RL, Balaji S, Hao T, Shen Y, Chavali AK, Thiele I, Yang X, Fan C, Mello E, Hill DE, Vidal M, Salehi-Ashtiani K, and Papin JA. Metabolic network analysis integrated with transcript verification for sequenced genomes. Nat Methods. 2009 Aug;6(8):589-92. DOI:10.1038/nmeth.1348 | PubMed ID:19597503 | HubMed [Nat_Methods_2009_Aug_6_589_92_Metabolic_network_analysis_integrated_with_transcript_verification_for_sequenced_genomes]
  9. Squires B, Macken C, Garcia-Sastre A, Godbole S, Noronha J, Hunt V, Chang R, Larsen CN, Klem E, Biersack K, and Scheuermann RH. BioHealthBase: informatics support in the elucidation of influenza virus host pathogen interactions and virulence. Nucleic Acids Res. 2008 Jan;36(Database issue):D497-503. DOI:10.1093/nar/gkm905 | PubMed ID:17965094 | HubMed [Nucleic_Acids_Res_2008_Jan_36_Database_issue_D497_503_BioHealthBase_informatics_support_in_the_elucidation_of_influenza_virus_host_pathogen_interactions_and_virulence]
  10. Luo F, Yang Y, Chen CF, Chang R, Zhou J, and Scheuermann RH. Modular organization of protein interaction networks. Bioinformatics. 2007 Jan 15;23(2):207-14. DOI:10.1093/bioinformatics/btl562 | PubMed ID:17092991 | HubMed [Bioinformatics_2007_Jan_15_23_207_214_Modular_organization_of_protein_interaction_networks]

All Medline abstracts: PubMed | HubMed

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