User:Robert Landick

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Contact Info

Robert Landick (an artistic interpretation)
  • Robert Landick
  • University of Wisconsin
  • Dept. of Biochemistry
  • 1550 Linden Dr. 5441 Microbial Sciences
  • Madison, WI 53706
  • Email me through OpenWetWare

I work in the Depts. of Biochemistry and Bacteriology at the University of Wisconsin-Madison on RNA polymerase stucture/function and gene regulatory mechanisms, and with colleagues in the Great Lakes Bioenergy Research Center on engineering new bioenergy microbes. I joined OpenWetWare to share information on microbial synthetic biology research. See my lab web site to learn more about our research on RNA polymerase. See the Great Lakes Bioenergy Research Center web site to learn about bioenergy research at UW.

Education

  • 1983, PhD Biological Chemistry, University of Michigan
  • 1975, BS Chemistry, University of Michigan

Research interests

  1. Structure/function of RNA polymerase
  2. Regulation of gene expression
  3. Microbial synthetic biology

Publications

Sone recent papers:

  1. Vassylyev DG, Vassylyeva MN, Zhang J, Palangat M, Artsimovitch I, and Landick R. Structural basis for substrate loading in bacterial RNA polymerase. Nature. 2007 Jul 12;448(7150):163-8. DOI:10.1038/nature05931 | PubMed ID:17581591 | HubMed [Paper1]
  2. Toulokhonov I, Zhang J, Palangat M, and Landick R. A central role of the RNA polymerase trigger loop in active-site rearrangement during transcriptional pausing. Mol Cell. 2007 Aug 3;27(3):406-19. DOI:10.1016/j.molcel.2007.06.008 | PubMed ID:17679091 | HubMed [Paper2]
  3. Kyzer S, Ha KS, Landick R, and Palangat M. Direct versus limited-step reconstitution reveals key features of an RNA hairpin-stabilized paused transcription complex. J Biol Chem. 2007 Jun 29;282(26):19020-8. DOI:10.1074/jbc.M701483200 | PubMed ID:17502377 | HubMed [Paper3]
  4. Herbert KM, La Porta A, Wong BJ, Mooney RA, Neuman KC, Landick R, and Block SM. Sequence-resolved detection of pausing by single RNA polymerase molecules. Cell. 2006 Jun 16;125(6):1083-94. DOI:10.1016/j.cell.2006.04.032 | PubMed ID:16777599 | HubMed [Paper4]
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All Medline abstracts: PubMed | HubMed

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