User:Nkuldell:20.020 working page
Introduction to Biological Engineering Design
A class for first-year MIT undergraduates who are interested in the engineering of biology.
[NK, can we renumber to 20.001A, allowing for a future in which 20.001B and 20.001C might cover engineering aproaches applied to biological science and engineering approaches applied to biomedical work, respectively?]
[DE, we can call it whatever the hell you want but I kinda liked the 20:20 number...it's the vision thing...the other niche versions sound great though...how many can we teach?]
- Understand the operation of genetic programs in prokaryotes and eukaryotes.
- Describe key enabling technologies that support the engineering of biology, including synthesis, abstraction and standardization.
- Develop awareness of issues of human practice that result from the development and application of biological technologies.
End of term project will be specification of the design of a system, allowing for a smooth transition to iGEM summer undergraduate research experience if desired.
Class tentative setup as 4-0-8
- 2x1hr lecture
- 2x1hr recitation (one to cover journal articles and other as Q/A time with TA)
- eight hours of work outside of class
- 2x1hr in class exams
- final design project
- no final exam
|WEEK||DAY||Lecture topic||Recitation article||For Next Time|
|1||2||NASCAR tour of the cell ||Lives of a Cell ||DNA structure refresher|
|2||1||Bacterial gene expression||Sigma description/Jacob and Monod|| Standards:digital vs analog |
Measurements: PoPS vs Northern
|2||2||Noisy gene expression||Weiss/van Oudenaarden|| Measurements: cell vs bulk |
|3||1||Genetic switch||Mark P-tashne|| Standards: transfer curve|
|3||2||Genetic circuit design||Toggle/Repressilator||Standards: genetically encoded logic functions|
|4||1||Registry: parts, devices, systems||Composition||Measurements: device (bacterial photography system?) characterization|
|4||2||Composition: physical vs functional||Standard assembly|
|5||1||Review session||Q/A with TA|
|6||1||Evolution||Darwin-lite||Standards: comment on ID ruling|
|7||1|| Forward genetics
|Design of genetic screens ||read: genetics text, plus genetics problem set|
|7||2||Sequencing projects||Systematic analysis of yeast genome || Standards: Registry vs SGD |
Project Task A
|8||1||Foundations for engineering: abstraction|
|8||2||Foundations for engineering: decoupling||Project Task B|
|9||1|| Reverse genetics
|9||2||Application: engineering therapeutics||JK's work  CV's work ||Preliminary project description due|
|10||1||Application: engineering for bioremediation/of bioresponsive agents|
|10||2||Review session||Q/A with TA|
|11||1||Exam II||no recitation|
|11||2||Socially responsible engineering||Help session for final project|
|12||1||Final project presentations (poster session if class large?)|