User:Megan N McClean

From OpenWetWare
Jump to: navigation, search

Contact Info

Megan N. McClean
  • Megan N McClean
  • University of Wisconsin
  • Engineering Centers Building 3156
  • 1550 Engineering Drive
  • Madison, WI 53706
  • Email me through OpenWetWare


I am an assistant professor at the University of Wisconsin.

Education

  • 2009-2014, Lewis-Sigler Fellow, Princeton University
  • 2009, PhD, Harvard
  • 2005, MS, Harvard
  • 2003, BA, University of California at Berkeley

Research interests

The McClean lab studies the design principles underlying the signal processing capabilities of biological networks. Cellular signaling networks transmit information about environmental stimuli to the interior of the cell, where successive cellular responses take place. How these networks process their input dictates cellular behavior and fitness. We are interested in how signaling pathways and transcriptional networks are designed to appropriately filter input and set thresholds so that cells respond optimally to changes in their environment. We are also interested in understanding how these networks are adapted and fine-tuned throughout development (short timescale) or evolution (long timescale). The lab takes an experimental approach combining microfluidics with microscopy to monitor the responses of signaling pathways to complex stimuli.

Please check out my Princeton webpage here: McClean Lab at Princeton

Check out our lab webpage on openwetware here: McClean Lab on Openwetware

Publications

  1. Hersen P, McClean MN, Mahadevan L, and Ramanathan S. Signal processing by the HOG MAP kinase pathway. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7165-70. DOI:10.1073/pnas.0710770105 | PubMed ID:18480263 | HubMed [Paper1]
  2. McClean MN, Mody A, Broach JR, and Ramanathan S. Cross-talk and decision making in MAP kinase pathways. Nat Genet. 2007 Mar;39(3):409-14. DOI:10.1038/ng1957 | PubMed ID:17259986 | HubMed [Paper2]
  3. McClean MN, Hersen P, and Ramanathan S. In vivo measurement of signaling cascade dynamics. Cell Cycle. 2009 Feb 1;8(3):373-6. DOI:10.4161/cc.8.3.7450 | PubMed ID:19177008 | HubMed [Paper3]
  4. Hersen P, McClean M, and Ramanathan S. [Dynamic analysis of cell signalling: the example of the Saccharomyces cerevisiae osmotic response]. Med Sci (Paris). 2008 Dec;24(12):1020-2. DOI:10.1051/medsci/200824121020 | PubMed ID:19116106 | HubMed [Paper4]
All Medline abstracts: PubMed | HubMed

Useful links