User:Marie-Eve Val
Marie-Eve VAL
INSTITUT PASTEUR
Unité "Plasticité du Génome Bactérien"
Département Génomes et Génétique
CNRS UMR3525
28 rue du Dr. Roux
75724 PARIS cedex 15
FRANCE
Email me through OpenWetWare
Research interests
I am a research associate in Didier Mazel's lab at the Institut Pasteur of Paris. I have a great interest in bacterial genome structuration, organization and maintenance ... and a special interest in multipartite genomes. Owing to its bi-chromosomal genome architecture and its importance in public health, Vibrio cholerae, the causative agent of cholera, has become a preferred model to study bacteria with multipartite genomes. My approach is to drastically alter V. cholerae’s genome structure to gain more insight into multipartite genomes. To do so, we developed a site-specific recombination-based engineering tool, which provides us with a powerful mean to massively reorganize in principle any prokaryotic genome.
Education
- 2008 - PhD
Centre de Génétique Moléculaire (Gif-sur-Yvette) , Francois-Xavier Barre's lab
Study of the system of chromosome dimer resolution in Vibrio cholerae and its implication in the control of the lysogeny of the phage CTX coding for the choleric toxin - 2003 - Engineering degree in biotechnology and Master in cellular and molecular biology
ESBS (Strasbourg, Freiburg, Karlsruhe and Basel) - 1999 - BS in Biotechnology
LVC (Gif-sur-Yvette)
Professional Training
- Since 2013 - INSERM Research Associate
Institut Pasteur (Paris) - Didier Mazel's lab - 2009 / 2013 - Post-Doctoral research fellow
Institut Pasteur (Paris) - Didier Mazel's lab - 2004 / 2008 - PhD Thesis
Centre de Génétique Moléculaire (Gif-sur-Yvette) , Francois-Xavier Barre's lab - 2004 - Engineer position
Génoscope - Consortium National de Recherche en Génomique (Evry) - Génolevures Consortium - 2003 - Master thesis
Center of Marine Biotechnology, UMBI (Baltimore) , Hal Schreier's lab - 2002 - Engineer training
IGBMC (Strasbourg) - Olivier POCH's lab - 2001 - Engineer training
Biozentrum (Basel) - Peter Philippsen's lab - 1999 / 2000 and summer 2002 - Technician position
AGROGENE(Moissy-Cramayel) - 1999 - Internship
Centre de Génétique Moléculaire (Gif-sur-Yvette) ,Fred Boccard's lab
Publications
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A checkpoint control orchestrates the replication of the two chromosomes of Vibrio cholerae
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Genomic location of the major ribosomal protein gene locus determines Vibrio cholerae global growth and infectivity
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Management of multipartite genomes: the Vibrio cholerae model
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Fuse or die: how to survive the loss of Dam in Vibrio cholerae
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Genome Engineering in Vibrio cholerae: A Feasible Approach to Address Biological Issues
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Molecular keys of the tropism of integration of the cholera toxin phage
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Comparative genomics of protoploid Saccharomycetaceae
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FtsK-dependent dimer resolution on multiple chromosomes in the pathogen Vibrio cholerae
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The single-stranded genome of phage CTX is the form used for integration into the genome of Vibrio cholerae
