User:Mahesh Chandra Patra

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Contact Info


  • Mahesh Chandra Patra
  • Ajou University, Suwon
  • South Korea

I work in the Lab of Innate immunity, Cell signaling, & Molecular modeling at Ajou University under the supervision of Prof. Sangdun Choi.

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  • 2020, PhD, Ajou University, Suwon, South Korea.
  • 2007, MS, Orissa University of Agriculture and Technology, Bhubaneswar, India.
  • 2005, BS, Govt. Autonomous College (Sambalpur University), Bhawanipatna, India.

Research interests

  1. Bioinformatics
  2. Immunology
  3. Structural biology
  4. Biological databases/software
  5. Drug design/discovery

Selected Publications

  1. Achek A, Kwon HK, Patra MC, Shah M, Hong R, Lee WH, Baek WY, Choi YS, Kim GY, Pham TLH, Suh CH, Kim W, Hahm DH, and Choi S. A peptide derived from the core β-sheet region of TIRAP decoys TLR4 and reduces inflammatory and autoimmune symptoms in murine models. EBioMedicine. 2020 Feb;52:102645. DOI:10.1016/j.ebiom.2020.102645 | PubMed ID:32014819 | HubMed [Paper1]
  2. Patra MC, Shah M, and Choi S. Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases. Semin Cancer Biol. 2020 Aug;64:61-82. DOI:10.1016/j.semcancer.2019.05.002 | PubMed ID:31054927 | HubMed [Paper2]
  3. Kwon HK, Patra MC, Shin HJ, Gui X, Achek A, Panneerselvam S, Kim DJ, Song SJ, Hong R, Kim KS, Kim YG, Lee FY, Hahm DH, Lee SH, and Choi S. A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice. Exp Mol Med. 2019 Apr 26;51(4):1-19. DOI:10.1038/s12276-019-0244-0 | PubMed ID:31028244 | HubMed [Paper3]
  4. Patra MC, Kwon HK, Batool M, and Choi S. Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer. Front Immunol. 2018;9:489. DOI:10.3389/fimmu.2018.00489 | PubMed ID:29593733 | HubMed [Paper4]
  5. Patra MC and Choi S. Insight into Phosphatidylinositol-Dependent Membrane Localization of the Innate Immune Adaptor Protein Toll/Interleukin 1 Receptor Domain-Containing Adaptor Protein. Front Immunol. 2018;9:75. DOI:10.3389/fimmu.2018.00075 | PubMed ID:29434596 | HubMed [Paper5]
  6. Patra MC and Choi S. Recent Progress in the Molecular Recognition and Therapeutic Importance of Interleukin-1 Receptor-Associated Kinase 4. Molecules. 2016 Nov 13;21(11). DOI:10.3390/molecules21111529 | PubMed ID:27845762 | HubMed [Paper6]
  7. Patra MC and Choi S. Recent progress in the development of Toll-like receptor (TLR) antagonists. Expert Opin Ther Pat. 2016 Jun;26(6):719-30. DOI:10.1080/13543776.2016.1185415 | PubMed ID:27136061 | HubMed [Paper7]
  8. Patra MC, Maharana J, Dehury B, and De S. Computational insights into the binding mechanism of antagonists with neuropeptide B/W receptor 1. Mol Biosyst. 2014 Aug;10(8):2236-46. DOI:10.1039/c4mb00214h | PubMed ID:24938207 | HubMed [Paper8]
  9. Dehury B, Patra MC, Maharana J, Sahu J, Sen P, Modi MK, Choudhury MD, and Barooah M. Structure-based computational study of two disease resistance gene homologues (Hm1 and Hm2) in maize (Zea mays L.) with implications in plant-pathogen interactions. PLoS One. 2014;9(5):e97852. DOI:10.1371/journal.pone.0097852 | PubMed ID:24847713 | HubMed [Paper9]
  10. Maharana J, Patra MC, De BC, Sahoo BR, Behera BK, De S, and Pradhan SK. Structural insights into the MDP binding and CARD-CARD interaction in zebrafish (Danio rerio) NOD2: a molecular dynamics approach. J Mol Recognit. 2014 May;27(5):260-75. DOI:10.1002/jmr.2357 | PubMed ID:24700593 | HubMed [Paper10]
  11. Patra MC, Rath SN, Pradhan SK, Maharana J, and De S. Molecular dynamics simulation of human serum paraoxonase 1 in DPPC bilayer reveals a critical role of transmembrane helix H1 for HDL association. Eur Biophys J. 2014 Jan;43(1):35-51. DOI:10.1007/s00249-013-0937-6 | PubMed ID:24297451 | HubMed [Paper11]
  12. Patra MC, Maharana J, Pradhan SK, and Rath SN. Molecular dynamics simulation of neuropeptide B and neuropeptide W in the dipalmitoylphosphatidylcholine membrane bilayer. J Biomol Struct Dyn. 2014;32(7):1118-31. DOI:10.1080/07391102.2013.811699 | PubMed ID:23815761 | HubMed [Paper12]
  13. Patra MC, Kumar K, Pasha S, and Chopra M. Comparative modeling of human kappa opioid receptor and docking analysis with the peptide YFa. J Mol Graph Model. 2012 Mar;33:44-51. DOI:10.1016/j.jmgm.2011.10.007 | PubMed ID:22172315 | HubMed [Paper13]

All Medline abstracts: PubMed | HubMed

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