User:Lionel Christiaen

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Contact Info

Lionel Christiaen
  • Lionel Christiaen
  • Department of Biology, Faculty of Arts and Science, New York University, 1009 Silver Building, 100 Washington Square East, New York, NY 10003-6688, USA
  • Email me through OpenWetWare
  • lab page


  • 2005-2009, Post-Doc, Levine lab, University of California, Berkeley (USA)
  • 2004, PhD, Université Paris XI (France)
  • 1999, MS, Ecole Normale Supérieure/Université Paris VI (France)
  • 1997, agrégation Life & Earth Sciences, Ecole Normale Supérieure/Université Paris XI (France)
  • 1996, BS, Ecole Normale Supérieure/Université Paris VI (France)

Research interests

  1. Gene regulatory networks and transcriptional control of actin dynamics, integrin adhesion, vesicle trafficking and cell polarity
  2. Function and regulation of the cellular processes underlying directed cell migration in development
  3. Quantitative imaging and systems biology


  1. Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, and Christiaen L. Early chordate origins of the vertebrate second heart field. Science. 2010 Jul 30;329(5991):565-8. DOI:10.1126/science.1190181 | PubMed ID:20671188 | HubMed [paper17]
  2. Tassy O, Dauga D, Daian F, Sobral D, Robin F, Khoueiry P, Salgado D, Fox V, Caillol D, Schiappa R, Laporte B, Rios A, Luxardi G, Kusakabe T, Joly JS, Darras S, Christiaen L, Contensin M, Auger H, Lamy C, Hudson C, Rothbächer U, Gilchrist MJ, Makabe KW, Hotta K, Fujiwara S, Satoh N, Satou Y, and Lemaire P. The ANISEED database: digital representation, formalization, and elucidation of a chordate developmental program. Genome Res. 2010 Oct;20(10):1459-68. DOI:10.1101/gr.108175.110 | PubMed ID:20647237 | HubMed [paper16]
  3. Haeussler M, Jaszczyszyn Y, Christiaen L, and Joly JS. A cis-regulatory signature for chordate anterior neuroectodermal genes. PLoS Genet. 2010 Apr 15;6(4):e1000912. DOI:10.1371/journal.pgen.1000912 | PubMed ID:20419150 | HubMed [paper15]
  4. Christiaen L, Wagner E, Shi W, and Levine M. The sea squirt Ciona intestinalis. Cold Spring Harb Protoc. 2009 Dec;2009(12):pdb.emo138. DOI:10.1101/pdb.emo138 | PubMed ID:20150076 | HubMed [paper14]
  5. Christiaen L, Stolfi A, and Levine M. BMP signaling coordinates gene expression and cell migration during precardiac mesoderm development. Dev Biol. 2010 Apr 15;340(2):179-87. DOI:10.1016/j.ydbio.2009.11.006 | PubMed ID:19913008 | HubMed [Paper13]
  6. Christiaen L, Stolfi A, Davidson B, and Levine M. Spatio-temporal intersection of Lhx3 and Tbx6 defines the cardiac field through synergistic activation of Mesp. Dev Biol. 2009 Apr 15;328(2):552-60. DOI:10.1016/j.ydbio.2009.01.033 | PubMed ID:19389354 | HubMed [Paper12]
  7. Christiaen L, Davidson B, Kawashima T, Powell W, Nolla H, Vranizan K, and Levine M. The transcription/migration interface in heart precursors of Ciona intestinalis. Science. 2008 Jun 6;320(5881):1349-52. DOI:10.1126/science.1158170 | PubMed ID:18535245 | HubMed [Paper11]
  8. Beh J, Shi W, Levine M, Davidson B, and Christiaen L. FoxF is essential for FGF-induced migration of heart progenitor cells in the ascidian Ciona intestinalis. Development. 2007 Sep;134(18):3297-305. DOI:10.1242/dev.010140 | PubMed ID:17720694 | HubMed [Paper10]
  9. Christiaen L, Jaszczyszyn Y, Kerfant M, Kano S, Thermes V, and Joly JS. Evolutionary modification of mouth position in deuterostomes. Semin Cell Dev Biol. 2007 Aug;18(4):502-11. DOI:10.1016/j.semcdb.2007.06.002 | PubMed ID:17656139 | HubMed [Paper9]
  10. Davidson B, Shi W, Beh J, Christiaen L, and Levine M. FGF signaling delineates the cardiac progenitor field in the simple chordate, Ciona intestinalis. Genes Dev. 2006 Oct 1;20(19):2728-38. DOI:10.1101/gad.1467706 | PubMed ID:17015434 | HubMed [Paper8]
  11. Davidson B and Christiaen L. Linking chordate gene networks to cellular behavior in ascidians. Cell. 2006 Jan 27;124(2):247-50. DOI:10.1016/j.cell.2006.01.013 | PubMed ID:16439196 | HubMed [Paper7]
  12. Moret F, Christiaen L, Deyts C, Blin M, Joly JS, and Vernier P. The dopamine-synthesizing cells in the swimming larva of the tunicate Ciona intestinalis are located only in the hypothalamus-related domain of the sensory vesicle. Eur J Neurosci. 2005 Jun;21(11):3043-55. DOI:10.1111/j.1460-9568.2005.04147.x | PubMed ID:15978015 | HubMed [Paper6]
  13. Moret F, Christiaen L, Deyts C, Blin M, Vernier P, and Joly JS. Regulatory gene expressions in the ascidian ventral sensory vesicle: evolutionary relationships with the vertebrate hypothalamus. Dev Biol. 2005 Jan 15;277(2):567-79. DOI:10.1016/j.ydbio.2004.11.004 | PubMed ID:15617694 | HubMed [Paper5]
  14. Christiaen L, Bourrat F, and Joly JS. A modular cis-regulatory system controls isoform-specific pitx expression in ascidian stomodaeum. Dev Biol. 2005 Jan 15;277(2):557-66. DOI:10.1016/j.ydbio.2004.10.008 | PubMed ID:15617693 | HubMed [Paper4]
  15. Tiozzo S, Christiaen L, Deyts C, Manni L, Joly JS, and Burighel P. Embryonic versus blastogenetic development in the compound ascidian Botryllus schlosseri: insights from Pitx expression patterns. Dev Dyn. 2005 Feb;232(2):468-78. DOI:10.1002/dvdy.20250 | PubMed ID:15614778 | HubMed [Paper3]
  16. Hendrickson C, Christiaen L, Deschet K, Jiang D, Joly JS, Legendre L, Nakatani Y, Tresser J, and Smith WC. Culture of adult ascidians and ascidian genetics. Methods Cell Biol. 2004;74:143-70. DOI:10.1016/s0091-679x(04)74007-8 | PubMed ID:15575606 | HubMed [Paper2]
  17. Christiaen L, Burighel P, Smith WC, Vernier P, Bourrat F, and Joly JS. Pitx genes in Tunicates provide new molecular insight into the evolutionary origin of pituitary. Gene. 2002 Apr 3;287(1-2):107-13. DOI:10.1016/s0378-1119(01)00865-4 | PubMed ID:11992728 | HubMed [Paper1]

All Medline abstracts: PubMed | HubMed

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