User:Johannes W. Dietrich

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Johannes Dietrich

PD Dr. Johannes Wolfgang Christian Dietrich
Consultant Endocrinologist
Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, NRW, Germany
Laboratory XU44
Bürkle-de-la-Camp-Platz 1
D-44789 Bochum, NRW, Germany
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I learned about OpenWetWare from Search engine (searching for biological simulation tools), and I've joined because I might be able to add content related to biomedical cybernetics and computational systems biology..


  • 2011, Board Certified Specialist for Internal Medicine, Endocrinology and Diabetes
  • 2001, Dr. med., Ludwig-Maximilian University of Munich
  • 1994, MD, Ludwig-Maximilian University of Munich

Research interests

  1. Biomedical cybernetics
  2. Differential proteomics
  3. Thyroid research


  1. Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, Hoermann R. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. eCollection 2016. PubMed PMID 27375554.
  2. Hoermann R, Larisch R, Dietrich JW, Midgley JE. Derivation of a multivariate reference range for pituitary thyrotropin and thyroid hormones: diagnostic efficiency compared with conventional single-reference method. Eur J Endocrinol. 2016 Jun;174(6):735-43. doi: 10.1530/EJE-16-0031. Epub 2016 Mar 7. PubMed PMID 26951601.
  3. Midgley JE, Larisch R, Dietrich JW, Hoermann R. Letter to the Editor: Comment on "Reconciling the Log-Linear and Non-Linear Aspects of the TSH-Free T4 Relationship: Intra-Individual Analysis of a Large Population" by Rothacker K.M., et al. J Clin Endocrinol Metab. 2016 Apr;101(4):L40-1. doi: 10.1210/jc.2016-1115. PubMed PMID 27032322.
  4. Müller P, Halbfass P, Szöllösi A, Dietrich JW, Fochler F, Nentwich K, Roos M, Krug J, Schmitt R, Mügge A, Deneke T. Impact of periprocedural anticoagulation strategy on the incidence of new-onset silent cerebral events after radiofrequency catheter ablation of atrial fibrillation. J Interv Card Electrophysiol. 2016 Mar 28. [Epub ahead of print] PubMed PMID 27020439.
  5. Midgley JE, Larisch R, Dietrich JW, Hoermann R. Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency. Endocrine connections. 2015; 4(4):196-205. PubMed [journal] PMID 26335522, PMCID PMC4557078
  6. Dietrich JW, Midgley JE, Larisch R, Hoermann R. Of rats and men: thyroid homeostasis in rodents and human beings. The lancet. Diabetes & endocrinology. 2015; 3(12):932-3. PubMed [journal] PMID 26590684
  7. Frank CU, Braeth S, Dietrich JW, Wanjura D, Loos U. Bridge Technology with TSH Receptor Chimera for Sensitive Direct Detection of TSH Receptor Antibodies Causing Graves' Disease: Analytical and Clinical Evaluation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2015; 47(12):880-8. PubMed [journal] PMID 26079838
  8. Müller P, Maier J, Dietrich JW, Barth S, Griese DP, et al. Association between left atrial low-voltage area, serum apoptosis, and fibrosis biomarkers and incidence of silent cerebral events after catheter ablation of atrial fibrillation. Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2015; 44(1):55-62. PubMed [journal] PMID 26048130
  9. Hoermann R, Midgley JE, Larisch R, Dietrich JW. Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2015; 47(9):674-80. PubMed [journal] PMID 25750078
  10. Müller P, Dietrich JW, Halbfass P, Abouarab A, Fochler F, et al. Higher incidence of esophageal lesions after ablation of atrial fibrillation related to the use of esophageal temperature probes. Heart rhythm : the official journal of the Heart Rhythm Society. 2015; 12(7):1464-9. PubMed [journal] PMID 25847474
  11. Müller P, Grabowski C, Schiedat F, Shin DI, Dietrich JW, et al. Reverse Remodelling of the Atria After Treatment of Obstructive Sleep Apnoea with Continuous Positive Airway Pressure: Evidence from Electro-mechanical and Endocrine Markers. Heart, lung & circulation. 2015; PubMed [journal] PMID 26184126
  12. Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, et al. Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling. European thyroid journal. 2015; 4(2):129-37. PubMed [journal] PMID 26279999, PMCID PMC4521060
  13. Schöfl C, Grussendorf M, Honegger J, Tönjes A, Thyroke-Gronostay D, et al. Failure to achieve disease control in acromegaly: cause analysis by a registry-based survey. European journal of endocrinology / European Federation of Endocrine Societies. 2015; 172(4):351-6. PubMed [journal] PMID 25599707
  14. Chatzitomaris A, Scheeler M, Gotzmann M, Köditz R, Schildroth J, et al. Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. Thyroid research. 2015; 8:6. PubMed [journal] PMID 26000037, PMCID PMC4440534
  15. Schade A, Schumacher B, Dietrich JW, Langbein A, Groschup G, et al. Stand-alone mapping using different transluminal mapping catheters--an accurate and safe way to isolate all pulmonary veins with the cryoballoon? Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2015; 42(1):33-41. PubMed [journal] PMID 25504268
  16. Hoermann R, Midgley JE, Larisch R, Dietrich JW. Homeostatic Control of the Thyroid-Pituitary Axis: Perspectives for Diagnosis and Treatment. Frontiers in endocrinology. 2015; 6:177. PubMed [journal] PMID 26635726, PMCID PMC4653296
  17. Hoermann R, Midgley JE, Giacobino A, Eckl WA, Wahl HG, et al. Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment. Clinical endocrinology. 2014; 81(6):907-15. PubMed [journal] PMID 24953754
  18. Deneke T, Nentwich K, Schmitt R, Christhopoulos G, Krug J, et al. Exchanging Catheters Over a Single Transseptal Sheath During Left Atrial Ablation is Associated with a Higher Risk for Silent Cerebral Events. Indian pacing and electrophysiology journal. 2014; 14(5):240-9. PubMed [journal] PMID 25408564, PMCID PMC4217296
  19. Goede SL, Leow MK, Smit JW, Klein HH, Dietrich JW. Hypothalamus-pituitary-thyroid feedback control: implications of mathematical modeling and consequences for thyrotropin (TSH) and free thyroxine (FT4) reference ranges. Bulletin of mathematical biology. 2014; 76(6):1270-87. PubMed [journal] PMID 24789568
  20. Rohrer S, Dietrich JW. [Refeeding syndrome: a review of the literature]. Zeitschrift fur Gastroenterologie. 2014; 52(6):593-600. PubMed [journal] PMID 24905111
  21. Dietrich JW. TSH − Physiologie, Funktionsstörungen und Einflussfaktoren auf die Referenzwerte EHK. 2014 April 28; 63(2):93-99. doi:10.1055/s-0033-1357626
  22. Knoop U, Dietrich JW, Heyer CM, Koch A, Knoop H. "Still crazy after all these years"--tuberculosis as an old disease with diverse facets in a thirty-five-year-old male patient. Pneumologie (Stuttgart, Germany). 2014; 68(3):206-7. PubMed [journal] PMID 24301553
  23. Goede SL, Leow MK, Smit JW, Dietrich JW. A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications. Mathematical biosciences. 2014; 249:1-7. PubMed [journal] PMID 24480737
  24. Müller P, Schiedat F, Bialek A, Bösche L, Ewers A, et al. Total atrial conduction time assessed by tissue doppler imaging (PA-TDI Interval) to predict early recurrence of persistent atrial fibrillation after successful electrical cardioversion. Journal of cardiovascular electrophysiology. 2014; 25(2):161-7. PubMed [journal] PMID 24118306
  25. Müller P, Deneke T, Schiedat F, Bösche L, Strauch J, et al. Increased preoperative serum apoptosis marker fas ligand correlates with histopathology and new-onset of atrial fibrillation in patients after cardiac surgery. Journal of cardiovascular electrophysiology. 2013; 24(10):1110-5. PubMed [journal] PMID 23790081
  26. Dietrich JW, Leow MK, Goede SL, Midgley JE, Landgrafe G, et al. Do thyroid-stimulating hormone, body weight, or body mass index serve as adequate markers to guide levothyroxine dose titration? Journal of the American College of Surgeons. 2013; 217(4):752-3. PubMed [journal] PMID 24054412
  27. Müller P, Hars C, Schiedat F, Bösche LI, Gotzmann M, et al. Correlation between total atrial conduction time estimated via tissue Doppler imaging (PA-TDI Interval), structural atrial remodeling and new-onset of atrial fibrillation after cardiac surgery. Journal of cardiovascular electrophysiology. 2013; 24(6):626-31. PubMed [journal] PMID 23398627
  28. Ehren M, Dietrich JW. [Woman with type 1 diabetes mellitus and rapidly progressive edema]. Deutsche medizinische Wochenschrift (1946). 2013; 138(18):940-4. PubMed [journal] PMID 23613372
  29. Dietrich JW, Ehren M, Ruff-Dietrich S, Klein HH. [43-year-old woman with diabetes and postoperative circulatory collapse]. Deutsche medizinische Wochenschrift (1946). 2013; 138(18):945-6. PubMed [journal] PMID 23613373
  30. Knoop H, Knoop U, Behr J, Heyer CM, Kuert S, et al. Syndrome of inadequate antidiuretic hormone secretion in pulmonary tuberculosis - a therapeutic challenge. Pneumologie (Stuttgart, Germany). 2013; 67(4):219-22. PubMed [journal] PMID 23420227
  31. Midgley JE, Hoermann R, Larisch R, Dietrich JW. Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of clinical pathology. 2013; 66(4):335-42. PubMed [journal] PMID 23423518
  32. Hoermann R, Midgley JE, Larisch R, Dietrich JW. Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? European journal of endocrinology / European Federation of Endocrine Societies. 2013; 168(2):271-80. PubMed [journal] PMID 23184912
  33. Dietrich JW. [Thyroid storm]. Medizinische Klinik, Intensivmedizin und Notfallmedizin. 2012; 107(6):448-53. PubMed [journal] PMID 22878518
  34. Giebelstein J, Poschmann G, Højlund K, Schechinger W, Dietrich JW, et al. The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes. Diabetologia. 2012; 55(4):1114-27. PubMed [journal] PMID 22282162
  35. Dietrich JW, Landgrafe G, Fotiadou EH. TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. Journal of thyroid research. 2012; 2012:351864. PubMed [journal] PMID 23365787, PMCID PMC3544290
  36. Boehm BO, Rosinger S, Belyi D, Dietrich JW. The parathyroid as a target for radiation damage. The New England journal of medicine. 2011; 365(7):676-8. PubMed [journal] PMID 21848480
  37. Ueberberg S, Deutschbein T, Klein HH, Dietrich JW, Akinturk S, et al. Protection from diabetes development by single-chain antibody-mediated delivery of a NF-κB inhibitor specifically to β-cells in vivo. American journal of physiology. Endocrinology and metabolism. 2011; 301(1):E83-90. PubMed [journal] PMID 21521716
  38. Germing A, Gotzmann M, Rausse R, Brodherr T, Holt S, et al. Normal values for longitudinal function of the right ventricle in healthy women >70 years of age. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology. 2010; 11(8):725-8. PubMed [journal] PMID 20418271
  39. Ueberberg S, Ziegler D, Schechinger W, Dietrich JW, Akinturk S, et al. In vitro phage display in a rat beta cell line: a simple approach for the generation of a single-chain antibody targeting a novel beta cell-specific epitope. Diabetologia. 2010; 53(7):1384-94. PubMed [journal] PMID 20369222
  40. Ueberberg S, Meier JJ, Waengler C, Schechinger W, Dietrich JW, et al. Generation of novel single-chain antibodies by phage-display technology to direct imaging agents highly selective to pancreatic beta- or alpha-cells in vivo. Diabetes. 2009; 58(10):2324-34. PubMed [journal] PMID 19592622, PMCID PMC2750237
  41. Boehm BO, Steinert M, Dietrich JW, Peter RU, Belyi D, et al. Thyroid examination in highly radiation-exposed workers after the Chernobyl accident. European journal of endocrinology / European Federation of Endocrine Societies. 2009; 160(4):625-30. PubMed [journal] PMID 19147598
  42. Proteome analysis in muscle biopsies of lean, obese and obese type 2 diabetic patients Klein HH, Giebelstein J, Dietrich JW, Schechinger W, Poschmann G, et al. Diabetologia. Spring 2009; 52(Suppl1):S99. My Bibliography [journal]
  43. Dietrich JW, Stachon A, Antic B, Klein HH, Hering S. The AQUA-FONTIS study: protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome. BMC endocrine disorders. 2008; 8:13. PubMed [journal] PMID 18851740, PMCID PMC2576461
  44. Dietrich JW, Brisseau K, Boehm BO. [Absorption, transport and bio-availability of iodothyronines]. Deutsche medizinische Wochenschrift (1946). 2008; 133(31-32):1644-8. PubMed [journal] PMID 18651367
  45. Dietrich JW, Boehm BO. Thyroxine in goiter, H. pylori infection, and gastritis. The New England journal of medicine. 2006; 355(11):1177; author reply 1177. PubMed [journal] PMID 16971728
  46. Dietrich JW, Gieselbrecht K, Holl RW, Boehm BO. Absorption kinetics of levothyroxine is not altered by proton-pump inhibitor therapy. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2006; 38(1):57-9. PubMed [journal] PMID 16477543
  47. Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U. Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis. Cybernetics and Systems. 2004 June 01; 35(4):315-31. doi:10.1080/01969720490443354
  48. Gärtner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. The Journal of clinical endocrinology and metabolism. 2002; 87(4):1687-91. PubMed [journal] PMID 11932302
  49. Fischer MR, Dietrich JW, Maleck M, Stade UD, Eitel F. [Computer-assisted instruction in medicine: a multicenter evaluation study in 7 German language media resource centers]. Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)). 2000; 62(5):289-94. PubMed [journal] PMID 10893877
  50. PubMed [journal]

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