User:Jeroen Saeij

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Contact Info

Jeroen Saeij (an artistic interpretation)

I am the PI of the Saeij lab at The Massachusetts Institute of Technology.

Education

Research interests

  1. Intracellular Parasites
  2. Strain-specific differences in host cell modulation
  3. Host differences in resistance to intracellular parasites

Publications

  1. Boyle JP, Saeij JP, Harada SY, Ajioka JW, and Boothroyd JC. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. Eukaryot Cell. 2008 Aug;7(8):1403-14. DOI:10.1128/EC.00073-08 | PubMed ID:18552283 | HubMed [paper1]
  2. Saeij JP, Arrizabalaga G, and Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. Infect Immun. 2008 Jun;76(6):2402-10. DOI:10.1128/IAI.01494-07 | PubMed ID:18347037 | HubMed [paper2]
  3. Boyle JP, Saeij JP, and Boothroyd JC. Toxoplasma gondii: inconsistent dissemination patterns following oral infection in mice. Exp Parasitol. 2007 Jul;116(3):302-5. DOI:10.1016/j.exppara.2007.01.010 | PubMed ID:17335814 | HubMed [paper3]
  4. Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, and Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature. 2007 Jan 18;445(7125):324-7. DOI:10.1038/nature05395 | PubMed ID:17183270 | HubMed [paper4]
  5. Saeij JP, Boyle JP, Coller S, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, and Boothroyd JC. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. Science. 2006 Dec 15;314(5806):1780-3. DOI:10.1126/science.1133690 | PubMed ID:17170306 | HubMed [paper5]
  6. Boyle JP, Rajasekar B, Saeij JPJ, Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley LD, White MW, and Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10514-10519. DOI:10.1073/pnas.0510319103 | PubMed ID:16801557 | HubMed [paper6]
  7. Boyle JP, Saeij JP, Cleary MD, and Boothroyd JC. Analysis of gene expression during development: lessons from the Apicomplexa. Microbes Infect. 2006 May;8(6):1623-30. DOI:10.1016/j.micinf.2005.11.017 | PubMed ID:16697685 | HubMed [paper7]
  8. Huttenhuis HB, Taverne-Thiele AJ, Grou CP, Bergsma J, Saeij JP, Nakayasu C, and Rombout JH. Ontogeny of the common carp (Cyprinus carpio L.) innate immune system. Dev Comp Immunol. 2006;30(6):557-74. DOI:10.1016/j.dci.2005.08.001 | PubMed ID:16406121 | HubMed [paper8]
  9. Saeij JP, Boyle JP, and Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. Trends Parasitol. 2005 Oct;21(10):476-81. DOI:10.1016/j.pt.2005.08.001 | PubMed ID:16098810 | HubMed [paper9]
  10. Saeij JP, Boyle JP, Grigg ME, Arrizabalaga G, and Boothroyd JC. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. Infect Immun. 2005 Feb;73(2):695-702. DOI:10.1128/IAI.73.2.695-702.2005 | PubMed ID:15664907 | HubMed [paper10]
  11. Joerink M, Saeij JP, Stafford JL, Belosevic M, and Wiegertjes GF. Animal models for the study of innate immunity: protozoan infections in fish. Symp Soc Exp Biol. 2004(55):67-89; discussion 243-5. PubMed ID:15446445 | HubMed [paper11]
  12. Saeij JP, Groeneveld A, Van Rooijen N, Haenen OL, and Wiegertjes GF. Minor effect of depletion of resident macrophages from peritoneal cavity on resistance of common carp Cyprinus carpio to blood flagellates. Dis Aquat Organ. 2003 Dec 3;57(1-2):67-75. DOI:10.3354/dao057067 | PubMed ID:14735923 | HubMed [paper12]
  13. Engelsma MY, Stet RJ, Saeij JP, and Verburg-van Kemenade BM. Differential expression and haplotypic variation of two interleukin-1beta genes in the common carp (Cyprinus carpio L.). Cytokine. 2003 Apr;22(1-2):21-32. PubMed ID:12946102 | HubMed [paper13]
  14. Saeij JP, de Vries BJ, and Wiegertjes GF. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Dev Comp Immunol. 2003 Dec;27(10):859-74. PubMed ID:12880636 | HubMed [paper14]
  15. Saeij JP, van Muiswinkel WB, van de Meent M, Amaral C, and Wiegertjes GF. Different capacities of carp leukocytes to encounter nitric oxide-mediated stress: a role for the intracellular reduced glutathione pool. Dev Comp Immunol. 2003 Jun-Jul;27(6-7):555-68. PubMed ID:12697312 | HubMed [paper15]
  16. Saeij JP, Verburg-van Kemenade LB, van Muiswinkel WB, and Wiegertjes GF. Daily handling stress reduces resistance of carp to Trypanoplasma borreli: in vitro modulatory effects of cortisol on leukocyte function and apoptosis. Dev Comp Immunol. 2003 Mar;27(3):233-45. PubMed ID:12590974 | HubMed [paper16]
  17. Saeij JP, Stet RJ, de Vries BJ, van Muiswinkel WB, and Wiegertjes GF. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance?. Dev Comp Immunol. 2003 Jan;27(1):29-41. PubMed ID:12477499 | HubMed [paper17]
  18. Saeij JP, Van Muiswinkel WB, Groeneveld A, and Wiegertjes GF. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology. 2002 Jan;124(Pt 1):77-86. PubMed ID:11817378 | HubMed [paper18]
  19. Saeij JP, Stet RJ, Groeneveld A, Verburg-van Kemenade LB, van Muiswinkel WB, and Wiegertjes GF. Molecular and functional characterization of a fish inducible-type nitric oxide synthase. Immunogenetics. 2000 Apr;51(4-5):339-46. PubMed ID:10803847 | HubMed [paper19]
  20. Saeij JP, Wiegertjes GF, and Stet RJ. Identification and characterization of a fish natural resistance-associated macrophage protein (NRAMP) cDNA. Immunogenetics. 1999 Oct;50(1-2):60-6. PubMed ID:10541807 | HubMed [paper20]
  21. Stet RJ, Kruiswijk CP, Saeij JP, and Wiegertjes GF. Major histocompatibility genes in cyprinid fishes: theory and practice. Immunol Rev. 1998 Dec;166:301-16. PubMed ID:9914921 | HubMed [paper21]
  22. Verburg-Van Kemenade BM, Saeij JP, Flik G, and Willems PH. Ca2+ signals during early lymphocyte activation in carp Cyprinus carpio L. J Exp Biol. 1998 Feb;201(Pt 4):591-8. PubMed ID:9438833 | HubMed [paper22]
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