User:Jarle Pahr/Genetic circuits

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Notes on designs for genetic circuits:

Regulatory motifs

Published circuits

A genetic bistable switch utilizing nonlinear protein degradation.:


Elowitz & Leiber 2000. A synthetic oscillatory network of transcriptional regulators.:

Toggle switches

Gardner et al. 2000. Construction of a genetic toggle switch in Escherichia coli:

Hypothetical/proposed circuits

Discrete-Time Signal Processing with DNA:


Tools for the design of genetic circuits:


Positive feedback circuits and memory.:

Emergence of complex behaviour from simple circuit structures.:

Engineering prokaryotic gene circuits:

Gene regulation: Towards a circuit engineering discipline. Harley H. McAdams and Adam Arkin:

Foundations for engineering biology. Hasty, J. , McMillen, D. & Collins, J. J. Engineered gene circuits. Nature 420, 224–230 (2002)

Reconstruction of genetic circuits:

A coherent feedforward loop design principle to sustain robustness of biological networks:

Automatic Compilation from High-Level Biologically-Oriented Programming Language to Genetic Regulatory Networks:

Automatic Design of Synthetic Gene Circuits through Mixed Integer Non-linear Programming:

Foundations for the design and implementation of synthetic genetic circuits:

Combining Genetic Circuit and Microbial Growth Kinetic Models: A Challenge for Biological Modelling :