User:Jarle Pahr/Bistability

Notes on how to achieve bistability in genetic circuits:

Building biological memory by linking positive feedback loops: http://www.pnas.org/content/107/1/175.full

Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling.: http://www.ncbi.nlm.nih.gov/pubmed/17930288

Interlinking positive and negative feedback loops creates a tunable motif in gene regulatory networks.: http://www.ncbi.nlm.nih.gov/pubmed/19658748

(2002) Self-perpetuating states in signal transduction: Positive feedback, double-negative feedback, and bistability. Curr Opin Cell Biol 14:140–148